Lipid core peptide targeting the cathepsin D hemoglobinase of<i>Schistosoma mansoni</i>as a component of a schistosomiasis vaccine

Dougall, Annette M.; Skwarczynski, Mariusz; Khoshnejad, Makan; Chandrudu, Saranya; Daly, Norelle L.; Tóth, István; Loukas, Alex

doi:10.4161/hv.27057

Cited by 25 publications

(25 citation statements)

References 47 publications

(75 reference statements)

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“…antischistosomal vaccines based on recombinant schistosomal APDs (Table 1) [56,57]. However, it has been proposed that helminth vaccines should be based on at least two parasite enzymes involved in different processes, for example hemoglobin digestion and larval maturation [58].…”

Section: Parasite Apds As Therapeutic Targetsmentioning

confidence: 99%

Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets

Sojka

Hartmann

Bartošová-Sojková

et al. 2016

Trends in Parasitology

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Section: Parasite Apds As Therapeutic Targetsmentioning

confidence: 99%

Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets

Sojka

Hartmann

Bartošová-Sojková

et al. 2016

Trends in Parasitology

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“…lysine) and lipoamino acid into one molecule. LCP has been extensively used as a peptide-based vaccine delivery system and showed high efficacy to stimulate immune responses against hookworm [19,20], malaria [21], Schistosoma [20,22] and cancer [23]. While the majority of reported LCP conjugates induced strong systemic responses, only lipopeptide 1 (Figure 1) was able to induce mucosal immunity [24].…”

Section: Introductionmentioning

confidence: 99%

Liposome-based intranasal delivery of lipopeptide vaccine candidates against group A streptococcus

et al. 2016

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Group A streptococcus, causing rheumatic heart diseases, kills approximately half a million people annually. There is no vaccine available against the infection. Mucosal immunity is vital in ensuring an individual is protected as this gram positive bacteria initially colonizes at the throat. Herein, we demonstrated that lipopeptides entrapped by liposomes induced both mucosal and systemic immunity. High levels of antibody (IgA and IgG) titres were detected even five months post immunization and lead vaccine candidate was able to induce humoral immune responses even after single immunization. Thus, the combination of lipopeptides and liposomes generates a very promising delivery system for intranasal vaccines.

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“…This result indicated the importance of epitope conformation for peptide subunit vaccine development. Importantly, both series of vaccine candidates that targeted hookworm and Schistosoma did not induce any hemolytic effect and were not toxic in vitro even at a high concentration (100 μM) [95,97].…”

Section: Lipid-based Self-assembled Nanostructurementioning

confidence: 98%

“…Moreover, the lipidic moiety in LCP is recognized by TLR2, thus has self-adjuvanting properties [91], is preferentially taken up by APCs, and induced strong immune responses against the incorporated antigens [92,93]. For example, Fuaad et al synthesized an LCP-based vaccine candidate against schistosomiasis carrying an epitope (p2, KQAEDKVKAGPTDEIQKINAKQLEDKVK) derived from cathepsin D hemoglobinase [94,95]. The conjugate self-assembled into nanoparticles with diameters of 30-80 nm.…”

Section: Lipid-based Self-assembled Nanostructurementioning

confidence: 99%

The application of self-assembled nanostructures in peptide-based subunit vaccine development

Zhao

Chandrudu

Skwarczynski

et al. 2017

European Polymer Journal

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Please cite this article as: Zhao, G., Chandrudu, S., Skwarczynski, M., Toth, I., The application of self-assembled nanostructures in peptide-based subunit vaccine development, European Polymer Journal (2017), doi: http:// dx.doi.org/10. 1016/j.eurpolymj.2017.02.014 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 1The application of self-assembled nanostructures in

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Lipid core peptide targeting the cathepsin D hemoglobinase ofSchistosoma mansonias a component of a schistosomiasis vaccine

Cited by 25 publications

References 47 publications

Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets

Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets

Liposome-based intranasal delivery of lipopeptide vaccine candidates against group A streptococcus

The application of self-assembled nanostructures in peptide-based subunit vaccine development

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