Lipedema: An inherited condition

Child, Anne H.; Gordon, Kristiana; Sharpe, Pip; Brice, Glen; Østergaard, Pia; Jeffery, Steve; Mortimer, Peter

doi:10.1002/ajmg.a.33313

Cited by 200 publications

(268 citation statements)

References 13 publications

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“…Prevalence within the population remains grossly under diagnosed [115] . According to an epidemiologic study by Földi E and Földi M [116] , lipedema affects 11% of the female population.…”

Section: Diagnosismentioning

confidence: 99%

“…According to an epidemiologic study by Földi E and Földi M [116] , lipedema affects 11% of the female population. At least seven cases have been reported in men with testosterone or GH deficiency, or liver disease [114,115,117] .…”

Section: Diagnosismentioning

confidence: 99%

“…In six families over three generations with lipedema, the inheritance pattern was autosomal dominant with incomplete www.chinaphar.com Herbst KL Acta Pharmacologica Sinica npg penetrance [115] .…”

Section: Inheritance Of Lipedemamentioning

confidence: 99%

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Rare adipose disorders (RADs) masquerading as obesity

2012

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Rare adipose disorders (RADs) including multiple symmetric lipomatosis (MSL), lipedema and Dercum's disease (DD) may be misdiagnosed as obesity. Lifestyle changes, such as reduced caloric intake and increased physical activity are standard care for obesity. Although lifestyle changes and bariatric surgery work effectively for the obesity component of RADs, these treatments do not routinely reduce the abnormal subcutaneous adipose tissue (SAT) of RADs. RAD SAT likely results from the growth of a brown stem cell population with secondary lymphatic dysfunction in MSL, or by primary vascular and lymphatic dysfunction in lipedema and DD. People with RADs do not lose SAT from caloric limitation and increased energy expenditure alone. In order to improve recognition of RADs apart from obesity, the diagnostic criteria, histology and pathophysiology of RADs are presented and contrasted to familial partial lipodystrophies, acquired partial lipodystrophies and obesity with which they may be confused. Treatment recommendations focus on evidencebased data and include lymphatic decongestive therapy, medications and supplements that support loss of RAD SAT. Associated RAD conditions including depression, anxiety and pain will improve as healthcare providers learn to identify and adopt alternative treatment regimens for the abnormal SAT component of RADs. Effective dietary and exercise regimens are needed in RAD populations to improve quality of life and construct advanced treatment regimens for future generations.

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Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

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Rare adipose disorders (RADs) masquerading as obesity

2012

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“…Lipomas may also be found in the adipose tissue as isolated or clustered masses which are non-encapsulated [12,14]. Lipedema primarily affects women, and is usually diagnosed at puberty or by the third decade [15]. Lipedema can be exacerbated or incited to develop by pregnancy and childbirth or menopause [16].…”

Section: Introductionmentioning

confidence: 99%

“…Even though lipedema can be an inherited condition, likely autosomal dominant passing from mother or father to daughter [15], there are currently no known associated genes.…”

Section: Introductionmentioning

confidence: 99%

Bucher’s Broom and Selenium Improve Lipedema: A Retrospective Case Study

TE¹

2013

Altern Integ Med

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Background: Butcher's broom plant extract has been reported to improve lymphatic flow and the trace mineral, selenium, has been shown to improve lymphedema. This retrospective case study examines the effectiveness of Butcher's broom in conjunction with selenium to decrease limb volume of a patient with lipedema, a common fat distribution disorder with excess adipose tissue fluid.Methods: Selenium (400 mcg) was initiated 6 days prior to limb volume evaluation utilizing perometry. The patient underwent physical therapy that consisted of manual lymph drainage (MLD) with Histological Variable Manual Technique (HIVAMAT), and compression bandaging. Butcher's broom (one gram daily) was added on day 95 of treatment in addition to selenium and both were continued through day 293 (end of study). Results:Total volume reduction over the study period for the left and right upper extremities and left and right lower extremities was 525 ml and 225 ml (p<0.05), and 1769 ml and 1614 ml (p<0.0001), respectively. The total percent volume reduction during the time period when MLD with HIVAMAT and compression bandaging were performed for the left and right legs was 70.6 and 79.0%, respectively. In the absence of compression bandaging, the left and right arms lost 21.2 and 10% of initial volumes, respectively at the 6 month follow-up visit. During the latter part of the study when the patient was performing a home maintenance program, at which time selenium and Butcher's broom were continued, the left and right lower extremities decreased an additional 29.4 and 20.9% of initial volumes, respectively, despite a lack of exercise due to a foot injury during the last 46 days. Conclusion:Butcher's broom and selenium may offer new tools in conjunction with physical therapy to improve swelling and pain associated with lipedema.

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Disorders of the Lymphatic Vessels

Mortimer

Gordon

2016

Rook's Textbook of Dermatology, Ninth Edition

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Lymphatic dysfunction interferes with fluid homeostasis, tissue immunity and peripheral fat mobilization. Any chronic oedema represents lymphatic failure. If impaired lymph drainage is solely responsible, then lymphoedema results. This produces characteristic skin changes known as elephantiasis as well as increased fat deposition in the subcutaneous tissues. Impaired immune cell trafficking results in an increased risk of infection, particularly cellulitis/erysipelas, which often becomes recurrent. This chapter describes the clinical consequences of lymphatic dysfunction and in particular the impact on the skin and subcutaneous tissues. The sections are divided according to common clinical presentations.

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Lipedema: An inherited condition

Cited by 200 publications

References 13 publications

Rare adipose disorders (RADs) masquerading as obesity

Rare adipose disorders (RADs) masquerading as obesity

Bucher’s Broom and Selenium Improve Lipedema: A Retrospective Case Study

Disorders of the Lymphatic Vessels

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