Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family

Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes

“…Betatrophin is a novel lipid metabolism regulator that inhibits lipoprotein lipase (LPL) activity and increases the TG level [4][5][6]. Fenzl et al showed that betatrophin was associated with plasma atherogenic lipids in obesity and type 2 diabetes, and not associated with beta cell function and glucose homeostasis [9].…”

“…In this context, Yi and colleagues found that betatrophin, a fat and liver derived hormone, had a powerful stimulatory effect on proliferation of beta cells [3]. Betatrophin is also a regulator of lipid metabolism and is alternatively referred to as TD26, RIFL, lipasin and angiopoietin-like protein 8 (ANGPTL8) [4][5][6]. Strong secretion of betatrophin was observed following blocking of the insulin receptor by S961 in a mouse model of insulin resistance.…”

ANGPTL8/betatrophin alleviates insulin resistance via the Akt-GSK3β or Akt-FoxO1 pathway in HepG2 cells

“…Recently, several groups independently studied a previously uncharacterized gene, officially designated C19 or f80 (human), or Gm6484 (mouse), but more commonly known as ANGPTL8/betatrophin, although it is also referred to as TD26 (3), RIFL (4), Lipasin (5,6), an ANGPTL8 (7). ANGPTL8/betatrophin is a protein secreted by the liver and white adipose tissue under conditions of insulin resistance and can improve glucose tolerance by promoting beta cell proliferation in the pancreas in mice (8)(9)(10).…”

In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats

“…It has recently been reported that betatrophin, also called angiopoietin-like protein 8 (ANGPTL8), is a hormone regulated by lipid metabolism that inhibits liver lipoprotein lipase and significantly increases serum triacylglycerol levels in mice [6][7][8][9][10][11]. A 596 bp ANGPTL8 cDNA was produced with a short secret sequence in the N-terminus that is highly enriched in the liver and adipocytes [6].…”