2019
DOI: 10.1016/j.tcb.2018.09.004
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Abstract: The lifespan of an organism is strongly influenced by environmental factors, including diet, and by internal factors, notably reproductive status. Lipid metabolism is critical for adaptation to external conditions or reproduction. Interestingly, specific lipid profiles are associated with longevity and increased uptake of certain lipids extends longevity in C. elegans and ameliorates disease phenotypes in humans. How lipids impact longevity, and how lipid metabolism is regulated during aging, is just beginning… Show more

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Cited by 102 publications
(82 citation statements)
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References 172 publications
(238 reference statements)
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“…Consistent with this, sod-3, a direct target of daf-16 was found to be overexpressed (Figure S6F). The transgenic worms also exhibited a higher level of lipids (Figures S7A and S7B), which along with the known role of daf-16 in promoting lipid synthesis (Papsdorf and Brunet, 2019) supports the model of pry-1 interacting with daf-16 to regulate lipids.…”
Section: Daf-16/foxo Functions Downstream Of Pry-1 To Maintain the LIsupporting
confidence: 77%
See 1 more Smart Citation
“…Consistent with this, sod-3, a direct target of daf-16 was found to be overexpressed (Figure S6F). The transgenic worms also exhibited a higher level of lipids (Figures S7A and S7B), which along with the known role of daf-16 in promoting lipid synthesis (Papsdorf and Brunet, 2019) supports the model of pry-1 interacting with daf-16 to regulate lipids.…”
Section: Daf-16/foxo Functions Downstream Of Pry-1 To Maintain the LIsupporting
confidence: 77%
“…These findings support a model of pry-1 activating a long-range signaling to modulate daf-16 function that in turn may affect cellular processes. One of the outcomes of pry-1 interaction with daf-16 could be to affect lipid metabolism, a biological process that is implicated in aging ( Papsdorf and Brunet, 2019) since both genes promote MUFA synthesis by transcriptionally regulating fatty acid desaturases such as fat-7 (Murphy et al, 2003;Ranawade et al, 2018;Zhang et al, 2013a). Other outcomes are also likely since DAF-16 interacts with multiple partners to regulate lifespan ( Lapierre and Hansen, 2012;Uno and Nishida, 2016).…”
Section: Discussionmentioning
confidence: 99%
“…These two signaling lipids mediate opposite cellular effects, S1P promoting proliferation and cell survival and ceramides promoting apoptosis. Interestingly, higher ceramides levels are associated with shorter lifespan in worms, and a decrease in S1P is often seen in age-related diseases such as Alzheimer's disease (Papsdorf and Brunet, 2018). There is also evidence that the degree of unsaturation of membrane phospholipids gets higher with age, increasing lipid peroxidation products that may lead to more cellular damage (Papsdorf and Brunet, 2018).…”
Section: Aging and Degenerative Diseasesmentioning
confidence: 99%
“…Importantly, when comparing MSCs isolated from young and old donors, Kilpinen et al (2013) did not describe significant differences. In addition, changes in lipid profiles with age appear to differ among tissues (Papsdorf and Brunet, 2018) potentially having different effects on the resident stem cells.…”
Section: Aging and Degenerative Diseasesmentioning
confidence: 99%
“…Two integrative meta-analyses of cross-tissue transcriptome datasets commonly identified differential regulation of lipogenic genes as a key signature of DR in mammals 14,18 . Consistently, lipid profiles change during normal ageing, whilst DR and related lifespan-extending interventions remodel lipid composition in C.elegans, Drosophila and mammals, and some of these changes are causal and essential for increased lifespan 19 .…”
Section: Introductionmentioning
confidence: 88%