Link between structural connectivity of the medial forebrain bundle, functional connectivity of the ventral tegmental area, and anhedonia in unipolar depression

Bracht, Tobias; Mertse, Nicolas; Walther, Sebastian; Lüdi, Karin; Breit, Sigrid; Federspiel, Andrea; Wiest, Roland; Denier, Niklaus

doi:10.1016/j.nicl.2022.102961

Cited by 19 publications

(12 citation statements)

References 67 publications

(103 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients of this observational study were recruited at the University Hospital of Psychiatry and Psychotherapy in Bern, Switzerland and includes participants of previous reports of cross-sectional data [ 14 , 17 , 34 ]. We recruited two patient groups with a current depressive episode (ECT-group, and TAU-group) and a HC group (for study flow see Supplementary Material, S1 ).…”

Section: Methodsmentioning

confidence: 99%

Distinct and shared patterns of brain plasticity during electroconvulsive therapy and treatment as usual in depression: an observational multimodal MRI-study

et al. 2023

Self Cite

View full text Add to dashboard Cite

Electroconvulsive therapy (ECT) is a highly effective treatment for depression. Previous studies point to ECT-induced volume increase in the hippocampi and amygdalae, and to increase in cortical thickness. However, it is unclear if these neuroplastic changes are associated with treatment response. This observational study aimed to address this research question by comparing neuroplasticity between patients with depression receiving ECT and patients with depression that respond to treatment as usual (TAU-responders). Twenty ECT-patients (16 major depressive disorder (MDD), 4 depressed bipolar disorder), 20 TAU-responders (20 MDD) and 20 healthy controls (HC) were scanned twice with multimodal magnetic resonance imaging (structure: MP2RAGE; perfusion: arterial spin labeling). ECT-patients were scanned before and after an ECT-index series (ECT-group). TAU-responders were scanned during a depressive episode and following remission or treatment response. Volumes and cerebral blood flow (CBF) of the hippocampi and amygdalae, and global mean cortical thickness were compared between groups. There was a significant group × time interaction for hippocampal and amygdalar volumes, CBF in the hippocampi and global mean cortical thickness. Hippocampal and amygdalar enlargements and CBF increase in the hippocampi were observed in the ECT-group but neither in TAU-responders nor in HC. Increase in global mean cortical thickness was observed in the ECT-group and in TAU-responders but not in HC. The co-occurrence of increase in global mean cortical thickness in both TAU-responders and in ECT-patients may point to a shared mechanism of antidepressant response. This was not the case for subcortical volume and CBF increase.

show abstract

Section: Methodsmentioning

confidence: 99%

Distinct and shared patterns of brain plasticity during electroconvulsive therapy and treatment as usual in depression: an observational multimodal MRI-study

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…We conclude that an anti-OCD network which can be addressed by DBS might be located outside and medial to the STN in the MVT (or more specifically, the VTA). This network was recently further characterized [1,2]. We should also take into account the possibility that the amSTN target [8] potentially works via current leaking out of amSTN medially and inferiorly [12].…”

mentioning

confidence: 99%

Resolving dyskinesias at sustained anti-OCD efficacy by steering of DBS away from the anteromedial STN to the mesencephalic ventral tegmentum – case report

et al. 2022

View full text Add to dashboard Cite

Here we describe therapeutic results in a female patient who underwent bilateral slMFB DBS for OCD. During a 35-month long course of stimulation, she suffered from stimulation-induced dyskinesia of her right leg which we interpreted as co-stimulation of the adjacent anteromedial subthalamic nucleus (amSTN). After reprogramming to steer the stimulation away from the amSTN medial into the direction of the mesencephalic ventral tegmentum (MVT which contains the ventral tegmental area, VTA), the dyskinesias disappeared. Remarkably, anti-OCD efficacy in the presented patient was preserved and achieved with a bilateral stimulation which by our imaging study fully avoided the amSTN.

show abstract

“…Our study sample includes participants of previous cross-sectional ( Bracht et al, 2022a , Bracht et al, 2022b , Mertse et al, 2022 ) and longitudinal studies ( Bracht et al, 2023 ). Patients with a current depressive episode that were scheduled for an ECT-index series at the ECT-clinic of the University Hospital of Psychiatry and Psychotherapy Bern were asked if they were interested to participate.…”

Section: Methodsmentioning

confidence: 99%

Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depression

Denier

Walther

Breit

et al. 2023

NeuroImage: Clinical

Self Cite

View full text Add to dashboard Cite

Link between structural connectivity of the medial forebrain bundle, functional connectivity of the ventral tegmental area, and anhedonia in unipolar depression

Cited by 19 publications

References 67 publications

Distinct and shared patterns of brain plasticity during electroconvulsive therapy and treatment as usual in depression: an observational multimodal MRI-study

Distinct and shared patterns of brain plasticity during electroconvulsive therapy and treatment as usual in depression: an observational multimodal MRI-study

Resolving dyskinesias at sustained anti-OCD efficacy by steering of DBS away from the anteromedial STN to the mesencephalic ventral tegmentum – case report

Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depression

Contact Info

Product

Resources

About