Linear IgA bullous dermatosis. Characterization of a subset of patients with concurrent IgA and IgG anti-basement membrane autoantibodies

C3d immunohistochemistry on formalin‐fixed tissue is a valuable tool in the diagnosis of bullous pemphigoid of the skin

“…DIF revealed linear depositions of IgA, IgG and C3 and C3d immunohistochemistry a linear pattern along the basement membrane zone in both cases. Similar cases have been reported as a subgroup of patients with subepidermal blistering diseases characterized by the presence of both IgA and IgG antibasement membrane antibodies 18–21 . The clinical findings and the histology of these patients mostly reflect the characteristics of linear IgA dermatosis 18–21 …”

Molecular Biological Aspects of Acquired Bullous Diseases

“…This is supported by studies (Mutasim et al, 1988) showing that when skin in organ cultures is exposed to bullous pemphigoid serum, bullous pemphigoid antibodies bind within the lamina lucida in most specimens and only occasionally within the cell, in contrast to indirect immunoelectron microscopic staining, which shows binding both intracellularly and in the lamina lucida. Similar results were found in biopsies from lesional skin of patients with bullous pemphigoid where immunoglobulins were deposited extracellularly (Chan et al, 1995). However, results from a recent study have shown that in situ-bound antibodies eluted from the skin of patients with bullous pemphigoid are preferentially directed against the 230-BP antigens (Korman, 1995).…”

Patients with Bullous Pemphigoid and Linear IgA Disease show a Dual IgA and IgG Autoimmune Response to BP180

“…Infrequently, the target antigens have been characterized in patients with both IgA and IgG anti-BMZ autoantibodies [27,[31][32][33]42]. In the present study we demonstrate that the concurrent appearance of IgA and IgG autoantibodies to BP180 is a common finding in sera from patients with BP and LAD.…”