Linear IgA Bullous Dermatosis: A Series of 17 Cases

Díaz, María Sol; Morita, L.; Ferrari, Bruno; Sartori, S; Greco, Margaret; Bonells, L. Sobrevias; González-Enseñat, M.A.; Villa, Margarita; Larralde, Margarita

doi:10.1016/j.adengl.2019.07.010

Cited by 13 publications

(11 citation statements)

References 13 publications

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“…One case of LABD shortly after receiving influenza vaccination has been described in a 54-year-old woman, 24 while two paediatric cases occurred 2 weeks after varicella and influenza vaccination are reported. 25 …”

Section: Discussionmentioning

confidence: 99%

Linear IGA bullous dermatosis potentially triggered by vaccination

Corrà

Bonciolini

Quintarelli

et al. 2022

Int J Immunopathol Pharmacol

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Linear IgA bullous dermatosis (LABD) is a mucocutaneous autoimmune blistering disease affecting both adults and children. It is caused by IgA antibodies targeting multiple antigens along the basement membrane zone, leading to disruption of dermoepidermal junction and development of bullous lesions which often presents in characteristic arrangement. Although most LABD cases have been reported to be idiopathic, different triggers have been described, including several drugs and infection. However, the occurrence of vaccine-induced cases of LABD is not widely known and accepted due to the few reports available. We present two cases of LABD occurred following different triggers, rising the suspicion for a possible pathogenetic role of vaccines.

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Section: Discussionmentioning

confidence: 99%

Linear IGA bullous dermatosis potentially triggered by vaccination

Corrà

Bonciolini

Quintarelli

et al. 2022

Int J Immunopathol Pharmacol

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“…There are reports of BP in paediatric population being triggered by various vaccinations ( 21 , 22 ). Moreover, linear IgA bullous dermatosis (LABD), an autoimmune blistering dermatosis sharing with BP the autoimmunity to the DEJ, can be induced by vaccinations in children ( 23 ). We diagnosed LABD developing right after simultaneous vaccinations with the Di-Te-Per, Act-HIB, and polio vaccines in an 18-month-old girl suggesting that there is a spectrum of living organisms-derived triggers of IgA-mediated autoimmune blistering dermatoses ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Infantile Bullous Pemphigoid: Triggering by COVID-19 Is Speculative

et al. 2021

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Bullous pemphigoid (BP) is a cutaneous disease triggered by numerous stimuli, where genetic milieu-influenced autoimmunity to hemidesmosomal proteins, namely, BP180 and/or BP230 initiate an inflammation leading to dermal-epidermal junction (DEJ) enzymatic pathological remodelling. Here, to the best of our knowledge, we present the first case of an infantile BP apparently triggered by COVID-19. BP should be included in differential diagnosis of infantile rashes showing blisters or vesicles or both as well as their prodromal and evolutionary lesions. Possible triggers, such as coronavirus disease 2019 (COVID-19), of BP in infancy should be identified and properly dealt with.

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“…4 CBDC can develop following vaccination or medication, or with an autoimmune condition or illness, among other causes. 5 Breast milk has been identified as a vector for neonatal transmission of IgA autoantibodies. 6 Child abuse must be excluded as a differential diagnosis for the presentation.…”

Section: Introductionmentioning

confidence: 99%

“…CBDC is associated with the human leucocyte antigen (HLA):CW7, HLA:B8, HLA:DR3 and HLA:DR2 4 . CBDC can develop following vaccination or medication, or with an autoimmune condition or illness, among other causes 5 . Breast milk has been identified as a vector for neonatal transmission of IgA autoantibodies 6 .…”

Section: Introductionmentioning

confidence: 99%

Clinical features of chronic bullous dermatosis of childhood

Wilson

Murrell

2022

Clin Experimental Derm

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Summary Background Chronic bullous dermatosis of childhood (CBDC) is a rare autoimmune subepidermal blistering disease, which can develop following vaccination or medication, or with an autoimmune condition or illness, among other causes. Aim To identify and better understand the clinical features of CBDC by performing a systematic review, in line with the Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines. Methods Eligible studies included publication since 1980, CBDC diagnosis, case studies, subjects aged < 18 years, clinical features and no language restriction. A database search was conducted including Embase, MEDLINE and Scopus on 14 July 2021 (see Appendix for search terms). Data were assessed for risk of bias. Jamovi was used for statistical analysis. Age and sex were compared with mucocutaneous involvement, cutaneous involvement, other symptoms, human leucocyte antigen type and lesion descriptions. Results After removing duplicate references using Endnote, 351 papers were identified, of which 91 met the inclusion criteria. These papers included 130 cases of CBDC: 110 children and 20 neonates. The ratio of male : female patients was 19 : 1 for neonates and 74:55 for children. χ² analysis with 1 degree of freedom showed that CBDC in neonates was associated with facial (χ²(1) = 9.67, P < 0.01), mouth (χ²(1) = 31.0, P < 0.001), upper airway (χ²(1) = 52.7, P < 0.001), oesophageal (χ²(1) = 34.6, P < 0.001), ophthalmic (χ²(1) = 6.27, P = 0.01) involvement and with respiratory distress (χ²(1) = 22.7 P < 0.001). CBDC in children was associated with genital (χ²(1) = 3.96, P < 0.05), arm (χ²(1) = 6.99, P < 0.01) and leg (χ²(1) = 7.03, P < 0.01) involvement. CBDC in male patients was associated with facial (χ²(1) = 7.01, P < 0.01), scalp (χ²(1) = 5.96, P < 0.02) and perianal (χ²(1) = 7.22, P < 0.01) involvement. Conclusion Neonates with CBDC are more likely to have a mucocutaneous distribution of lesions, whereas children are more likely to have cutaneous lesions. The limitations of this study include selection bias, and the small neonate sample size makes the study unrepresentative of the population. The review highlights the need for further research into the clinical features of CBDC in neonates.

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Linear IgA Bullous Dermatosis: A Series of 17 Cases

Cited by 13 publications

References 13 publications

Linear IGA bullous dermatosis potentially triggered by vaccination

Linear IGA bullous dermatosis potentially triggered by vaccination

Case Report: Infantile Bullous Pemphigoid: Triggering by COVID-19 Is Speculative

Clinical features of chronic bullous dermatosis of childhood

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