Linear Dextrin as Potential Insulin Delivery System: Effect of Degree of Polymerization on the Physicochemical Properties of Linear Dextrin–Insulin Inclusion Complexes

Abstract

In the current study, linear dextrin (LD) was prepared using waxy potato starch debranched with pullulanase, which has attracted immense interest in the food, pharmaceutical, and cosmetic industries as a versatile ingredient. Various LDs were separated on the basis of their differential solubility in aqueous/ethanol solutions of different volumetric ratios. Three LD products—LD Fabrications with 40% ethanol (F-40); LD Fabrications with 50% ethanol (F-50); and LD Fabrications with 60%, 70%, and 80% ethanol (F-M)—were obtained with an average degree of polymerization (DP) values of 31.44, 21.84, and 16.10, respectively. The results of Fourier transform infrared spectroscopy (FT-IR) analysis revealed that the reaction mainly involved hydrogen bonding and a hydrophobic interaction between LD and insulin in the process of inclusion complex formation. X-ray diffraction (XRD) results indicated that insulin was encapsulated in LD. The results of circular dichroism (CD) showed that the changes in the secondary structure of insulin were negligible during the release from the inclusion complexes. The order of encapsulation capacity is as follows: the complex composed of F-M and insulin (F-M-INS) > the complex composed of LD and insulin (LD-INS) > the complex composed of F-50 and insulin (F-50-INS) > and the complex composed of F-40 and insulin (F-40-INS). F-M-INS inclusion complexes showed a better effect on reducing the release of insulin in gastric juice and promoting the release of insulin in intestinal juice and blood plasma than LD-INS.

Advancements in application of chitosan and cyclodextrins in biomedicine and pharmaceutics: recent progress and future trends

“…They have found widespread use in pharmaceutical science and technologies for several purposes, including enhancing the dissolution and duration of drugs in liquids, improving the efficacy of drug absorption into the body, masking odors and tastes, regulating the release rate of drugs in the body, reducing local and systemic toxicity, and facilitating the passage of drugs through biological barriers. 92,93 Medications containing cyclodextrins can be administered orally, intranasally, ocularly, or transdermally. 94 In order to enhance the pharmaceutical characteristics of natural cyclodextrins for medical applications, researchers have subjected them to chemical modications.…”

“…They have found widespread use in pharmaceutical science and technologies for several purposes, including enhancing the dissolution and duration of drugs in liquids, improving the efficacy of drug absorption into the body, masking odors and tastes, regulating the release rate of drugs in the body, reducing local and systemic toxicity, and facilitating the passage of drugs through biological barriers. 92,93…”

Bio‐Based Hybrid Catalysts for the Synthesis of Pharmacologically Active Xanthenes

“…Linear dextrin (LD) refers to a linear polymer in its strict sense. [10] It is a mixture of D-glucose units' polymers linked by α- (1!4) glycosidic bonds (Scheme 1). [11] The catalytic application of these valuable natural biopolymers is of particular importance.…”

“…In the present study, linear dextrin has been used as a substrate for the catalyst. Linear dextrin (LD) refers to a linear polymer in its strict sense [10] . It is a mixture of D‐glucose units’ polymers linked by α ‐(1→4) glycosidic bonds (Scheme 1).…”

Study of the Antiviral Activity and Toxicity of Dextrin - In Vitro Study

“…Dextrins, in terms of molecular concentration per linear, branched dextrin and cyclodextrin, have the same physicochemical and biological characteristics [3]. Cyclodextrins are more resistant to non-enzymatic hydrolysis.…”