Linear Cutaneous Lupus Erythematosus with Calcinosis Cutis and Milia

Abstract

Linear cutaneous lupus erythematosus (LCLE) is an unusual manifestation of cutaneous lupus erythematosus in which erythematous, atrophic, dyschromic lesions are located along the lines of Blaschko. Calcinosis cutis and secondary milia are very uncommon in lupus erythematosus. We present a rare case of LCLE with calcinosis cutis and milia.

Facial calcinosis cutis in a patient with systemic lupus erythematosus: A case report of tissue injury owing to photosensitivity as the cause of dystrophic calcification

“…There is one report of calcinosis cutis in an adolescent involving the mandible and submandibular area in association with linear cutaneous lupus erythematosus, a form of discoid lupus. 5 Preauricular platelike calcification in SLE has not been previously reported.…”

“… 1 It is rarely described in association with SLE, and there are only approximately 45 documented cases to date. 2 , 3 , 4 , 5 , 6 , 7 , 8 Many of these patients were on systemic steroids or suffered mechanical trauma or tissue injury secondary to myopathy, skin ulcerations, and, rarely, osteonecrosis or bone infarction. The time of onset for dystrophic calcinosis is typically 20 years after the onset of SLE but is around 5 years in cases associated with lupus panniculitis.…”

“…The time of onset for dystrophic calcinosis is typically 20 years after the onset of SLE but is around 5 years in cases associated with lupus panniculitis. 2 , 3 , 4 , 5 , 6 , 7 Most cases involved the extremities and buttocks in women. Although most cases of calcinosis with SLE are dystrophic and localized in nature, diffuse calcification involving the muscle and fascia, known as calcinosis universals , has also been described.…”

Functional Regulation Triad of Mitosis, Apoptosis and Thigmotropism of Survivin in Cutaneous Malignant Melanoma

“…Till now, fewer than 30 cases in both adults and children have been published [4,5]. Among them, only 15 cases of childhood diagnosed as facial LCLE have been reported (Table 1) [3,[6][7][8][9][10][11][12][13][14][15][16]. Nearly half of the cases presented with lesions before the age of 7 years.…”

“…Previously reported therapies for facial LCLE of childhood include topical steroids [7,8,10,[14][15][16], pimecrolimus [11], tarcrolimus [12][13][14], oral steroids [16], dapsone [3,8], hydroxychloroquine [6,9,11,13], isotretinoin [11], and intense pulsed light [11]. However, patients show various responses to these therapies.…”