Line‐field confocal optical coherence tomography in the treatment monitoring of actinic keratosis with tirbanibulin: A pilot study

Lacarrubba, Francesco; Verzì, Anna Elisa; Polita, Matteo; Aleo, Alice; Micali, Giuseppe

doi:10.1111/jdv.19147

Cited by 10 publications

(4 citation statements)

References 10 publications

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“…No patient experienced systemic effects related to the drug. The LSRs did not cause any discomfort to patients, who all completed the treatment, thus confirming a favorable safety profile of tirbanibulin [36][37][38]. Furthermore, we assessed patient treatment satisfaction, resulting from factors such as effectiveness, convenience (e.g., route of administration, dosing frequency), or drug side effects.…”

Section: Discussionmentioning

confidence: 59%

Preliminary Evidence of Efficacy, Safety, and Treatment Satisfaction with Tirbanibulin 1% Ointment: A Clinical Perspective on Actinic Keratoses

Campione,

Rivieccio,

Gaeta Shumak

et al. 2023

Pharmaceuticals

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Background: Actinic keratosis is a common precancerous skin lesion that can progress into invasive squamous cell carcinomas. Many topical treatments for actinic keratoses often have poor tolerability and prolonged duration. Tirbanibulin is a novel synthetic drug with potent antitumor and antiproliferative activities. Methods: We conducted a single-center, prospective and observational study using tirbanibulin ointment on a 25 cm2 area for 5 consecutive days on 30 participants with AKs on the face or scalp. They were followed for at least 57 days to assess the safety profile and efficacy of the drug as well as treatment satisfaction. We evaluated six signs of local skin reaction (LSR): erythema, scaling, crusting, swelling, blisters/pustules, and erosions/ulcerations, grading the severity as mild, moderate, or severe. The effectiveness was evaluated both clinically and dermoscopically. The treatment satisfaction was assessed using the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Results: On day 57, 70% of the patients showed a complete clinical and dermoscopic response. The highest scores obtained from the TSQM 1.4 were more evident in the convenience and side effects domains. Most LSRs, including erythema (83.3%), scaling (30%), and swelling (3.3%), occurred on day 8 but resolved spontaneously. Conclusion: Tirbanibulin is a viable therapeutic option with a short regimen treatment and good tolerability, which favors therapy adherence.

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Section: Discussionmentioning

confidence: 59%

Preliminary Evidence of Efficacy, Safety, and Treatment Satisfaction with Tirbanibulin 1% Ointment: A Clinical Perspective on Actinic Keratoses

Campione,

Rivieccio,

Gaeta Shumak

et al. 2023

Pharmaceuticals

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“…This approach allows for the differentiation of pathological skin from healthy skin, as illustrated in Figure 9b,c for AK. This algorithm was demonstrated to have the potential to grade pre-cancerous keratinocytic lesions and help in treatment monitoring [48]. DAMAE Medical has developed deep learning algorithms for the segmentation of skin layers and keratinocyte nuclei in LC-OCT images.…”

Section: Actinic Keratosis and Squamous Cell Carcinomamentioning

confidence: 99%

Section: Actinic Keratosis and Squamous Cell Carcinomamentioning

confidence: 99%

Line-Field Confocal Optical Coherence Tomography (LC-OCT) for Skin Imaging in Dermatology

Latriglia,

Ogien,

Tavernier

et al. 2023

Life

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Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive optical imaging technique based on a combination of the principles of optical coherence tomography and reflectance confocal microscopy with line-field illumination, which can generate cell-resolved images of the skin in vivo. This article reports on the LC-OCT technique and its application in dermatology. The principle of the technique is described, and the latest technological innovations are presented. The technology has been miniaturized to fit within an ergonomic handheld probe, allowing for the easy access of any skin area on the body. The performance of the LC-OCT device in terms of resolution, field of view, and acquisition speed is reported. The use of LC-OCT in dermatology for the non-invasive detection, characterization, and therapeutic follow-up of various skin pathologies is discussed. Benign and malignant melanocytic lesions, non-melanocytic skin tumors, such as basal cell carcinoma, squamous cell carcinoma and actinic keratosis, and inflammatory and infectious skin conditions are considered. Dedicated deep learning algorithms have been developed for assisting in the analysis of LC-OCT images of skin lesions.

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“…In addition, LC‐OCT has been used to visualize features of dermatological pathologies including pustular skin disorders, psoriasis, eczema, lichen planus, melanoma, dysplastic nevi, nevus, basosquamous carcinoma, basal cell carcinomas, squamous cell carcinoma, and actinic keratosis. 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 Therefore, using LC‐OCT, we aim to better elucidate the early cutaneous surface and subsurface kinetic effects of hydradermabrasion, through LC‐OCT, as its use in cosmetic dermatology continues to grow.…”

Section: Introductionmentioning

confidence: 99%

Hydradermabrasion through the lens of Line‐Field Confocal Optical Coherence Tomography

Razi,

Truong,

Khan

et al. 2024

Skin Research and Technology

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BackgroundHydradermabrasion, also known as “HydraFacial,” is an exfoliative cosmetic procedure for skin rejuvenation that has gained popularity. Despite its increasing popularity, clinical studies validating its efficacy with non‐invasive assessment of histological changes to the skin, are scarce. In this study, we used Line‐Field Confocal Optical Coherence Tomography (LC‐OCT), an optical imaging device, to non‐invasively visualize microscopic changes to skin anatomy after hydradermabrasion treatment.Materials/MethodsEight volunteers (Fitzpatrick skin types II–V) were recruited for this study. Images, using LC‐OCT (DeepLive, DAMAE medical) were obtained before and after hydradermabrasion and at 2 weeks post‐treatment. A commercially available hydradermabrasion device was utilized to perform the dermabrasion.ResultsIn the epidermis, initially, a decrease in the average thickness of the stratum corneum, from 9.42 to 6.67 µm was visualized in LC‐OCT images after hydradermabrasion. However, at 2 weeks of follow‐up, the average stratum corneum thickness was 9.75 µm, resulting in an overall increase in the average thickness after treatment. Improved homogenization of the stratum corneum and decreased number of undulations in the epidermis post‐treatment were also visualized. In all the subjects, the superficial dermis appeared stretched, which returned to baseline by the 2‐week follow‐up. At the 2‐week follow‐up, there were no visible differences in the quality and quantity of collagen fibers in the dermis.ConclusionIn our study, LC‐OCT images of the epidermis and dermis demonstrated microscopic features of skin rejuvenation when treated with hydradermabrasion. Thus, not only highlighting the efficacy of hydradermabrasion but also the potential of LC‐OCT to serve as a tool for visualizing the microscopic effects of cosmetic procedures on skin anatomy.

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Line‐field confocal optical coherence tomography in the treatment monitoring of actinic keratosis with tirbanibulin: A pilot study

Cited by 10 publications

References 10 publications

Preliminary Evidence of Efficacy, Safety, and Treatment Satisfaction with Tirbanibulin 1% Ointment: A Clinical Perspective on Actinic Keratoses

Preliminary Evidence of Efficacy, Safety, and Treatment Satisfaction with Tirbanibulin 1% Ointment: A Clinical Perspective on Actinic Keratoses

Line-Field Confocal Optical Coherence Tomography (LC-OCT) for Skin Imaging in Dermatology

Hydradermabrasion through the lens of Line‐Field Confocal Optical Coherence Tomography

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