1987
DOI: 10.1001/archderm.123.8.1056
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Lindane neurotoxic reaction in nonbullous congenital ichthyosiform erythroderma

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Cited by 11 publications
(4 citation statements)
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“…J Invest Dermatol 117:710±717, 2001 I mpairment of human stratum corneum (SC) barrier function can lead to increased transepidermal water loss (TEWL) and increased susceptibility to intoxication by penetration of harmful agents. This has been observed in various skin diseases (Rasmussen, 1979;Friedman, 1987;Lavrijsen et al, 1993;Tupker et al, 1993). It has generally been accepted that the lipid organization in the intercellular matrix of human SC plays a key part in the creation of the SC barrier.…”
mentioning
confidence: 62%
“…J Invest Dermatol 117:710±717, 2001 I mpairment of human stratum corneum (SC) barrier function can lead to increased transepidermal water loss (TEWL) and increased susceptibility to intoxication by penetration of harmful agents. This has been observed in various skin diseases (Rasmussen, 1979;Friedman, 1987;Lavrijsen et al, 1993;Tupker et al, 1993). It has generally been accepted that the lipid organization in the intercellular matrix of human SC plays a key part in the creation of the SC barrier.…”
mentioning
confidence: 62%
“…Lindane is effective on eggs of lice, but lindane resistance among head lice has been reported in the United Kingdom, the Netherlands, Panama, and the United States . Easy absorption of lindane to skin can cause neurotoxicity and anemia in patients . For this reason, this treatment should be applied with extreme caution in patients with a history of seizure and in HIV infected patients .…”
Section: Resultsmentioning
confidence: 99%
“…In humans, in addition to the presence of a uniformly good diffusion barrier throughout the horny layer of skin, various other factors affect the pharmacokinetics of percutaneous absorption of topically applied substances (7). Lindane binds to plasma proteins and epidermis with a much greater affinity compared to dermis and subcutaneous tissue (8). Being lipid soluble, it is also readily absorbed via transcutaneous absorption, ranging from 9% to more than 80% (6).…”
Section: Discussionmentioning
confidence: 99%