2021
DOI: 10.3389/fonc.2020.614455
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Abstract: Long non-coding RNAs (lncRNAs) are the most heterogeneous class of non-protein-coding RNAs involved in a broad spectrum of molecular mechanisms controlling genome function, including the generation of complex networks of RNA-RNA competitive interactions. Accordingly, their dysregulation contributes to the onset of many tumors, including colorectal cancer (CRC). Through a combination of in silico approaches (statistical screening of expression datasets) and in vitro analyses (enforced expression, artificial inh… Show more

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Cited by 14 publications
(15 citation statements)
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“…Other previous studies reported a systemic integrated view of RNA correlations in UM [ 35 , 36 ]; however, in this present work we propose the most comprehensive analysis and make these elaborations available through an interactive web-based user interface. The approach used to build VECTOR was already used in our previous papers on both UM and other cancer models [ 12 , 15 , 37 ]. In these previous studies, data about expression, interactions, and potential regulation operated by TFs were retrieved from different sources and databases, making this analysis complicated and time-consuming.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Other previous studies reported a systemic integrated view of RNA correlations in UM [ 35 , 36 ]; however, in this present work we propose the most comprehensive analysis and make these elaborations available through an interactive web-based user interface. The approach used to build VECTOR was already used in our previous papers on both UM and other cancer models [ 12 , 15 , 37 ]. In these previous studies, data about expression, interactions, and potential regulation operated by TFs were retrieved from different sources and databases, making this analysis complicated and time-consuming.…”
Section: Discussionmentioning
confidence: 99%
“…Conversely, downregulation of a specific lncRNA induces miRNA release and mRNA degradation or reduced translation [ 9 ]. This “miRNA sponge” function operated by lncRNAs has been described in many cancer models [ 10 , 11 , 12 , 13 ], including UM [ 14 , 15 ]. It has been reported that perturbations of the ceRNA network influence all the cellular signaling underlying cancer phenotypes; however, this topic is currently still poorly investigated in UM.…”
Section: Introductionmentioning
confidence: 99%
“…HNF4α also inhibits IL-24, a proinflammatory and tumor suppressive pathway, through upregulation of LINC00511 and promotes CRC proliferation, migration, and metastasis [169]. The low level of another lncRNA, LINC00483, was found to be correlated with harmful clinical features of colorectal cancer [170]. In vitro experiments showed a likely role of LINC00483 in the inhibition of EMT through a negative regulation by HNF4α.…”
Section: Hnf4α In Colorectal Cancer (Crc): Friend or Foe?mentioning
confidence: 99%
“…Post-transcriptional regulation is mainly mediated by the ceRNA mechanism, whereas translation and post-translational protein degradation are mediated by binding to the protein in the cytoplasm ( 18 ). Linc00483 has been found to act as a potential tumor suppressor in colorectal cancer (CRC) via ceRNA mechanism in the cytoplasm ( 19 ). Cytoplasmic lncRNA ALAL-1 regulates lung cancer immune evasion by binding to SART3 and affecting nuclear translocation of USP4 in ( 20 ).One of the most important mechanisms which ncRNA regulates cancer progression is interacting with miRNA or protein.…”
Section: Subcellular Localization and Function Of Linc01133mentioning
confidence: 99%