Linalyl acetate prevents three related factors of vascular damage in COPD-like and hypertensive rats

Hsieh, Yu Shan; Shin, You Kyoung; Han, A Young; Kwon, Sae-Hyuk; Seol, Geun Hee

doi:10.1016/j.lfs.2019.116608

Cited by 13 publications

(12 citation statements)

References 59 publications

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“…Both lavender and linalyl acetate suppressed disease activity by reducing the level of IL-6. IL-6 has been shown to inhibit NF-κB activation, inducing excessive immunologic responses [11,18]. Lavender had limited effects on properties associated with systemic in ammation, such as paw edema, serum IL-6 concentration and systolic BP.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, lavender oil has possibility of preventing cardiovascular disease based on anti-diabetic [14] and antithrombotic activities [15]. Linalyl acetate, a volatile and low toxicity compound contained in citrus fruits, is the main component of lavender oil [16] Linalyl acetate has shown anti-in ammatory effects in vitro [17] and in vivo [18], as well as anti-hypertensive [19], anti-diabetic [20] and anti-stress [21] effects with the ability to prevent vascular endothelium dysfunction [18]. These pharmacological properties suggested that lavender and linalyl acetate could have preventive effects in our rat model of RA with chronic nicotine-induced HTN.…”

Section: Introductionmentioning

confidence: 99%

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Prophylactic Application of Lavandula Angustifolia Mill. Oil and Its Active Component Linalyl Acetate Alleviate Comorbidity and Exacerbation Risk in Rats With Collagen-Induced Arthritis Accompanied by Chronic Nicotine-Induced Hypertension.

Seo¹,

Hsieh²,

Lee³

et al. 2020

Preprint

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Background: Hypertension (HTN) in rheumatoid arthritis (RA) is more common in smokers than in non-smokers, increasing the risks of cardiovascular and skeletal muscle related comorbidities, but studies on pharmacological protection strategies are insufficient. Lavandula angustifolia Mill. (lavender) oil has traditionally been used for RA and HTN via its anti-inflammatory properties. This study aimed to investigate the effects of lavender oil and its main component linalyl acetate on cardiovascular and skeletal muscle protection in a rat model of RA with chronic nicotine-induced HTN. Methods: Collagen-induced arthritis (CIA), with or without chronic nicotine-induced HTN, were induced in Sprague-Dawley rats. Lavender or linalyl acetate (10 or 100 mg/kg/day) were administrated intraperitoneally to CIA plus chronic nicotine-induced HTN (H-CIA) rats. The effects of lavender and linalyl acetate was evaluated by measurement of hind paw thickness, body weight, blood pressure (BP), serum concentrations of interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1). In addition to above, histological analysis of thoracic aorta and gastrocnemius muscle were used. Results: BP was significantly higher, vascular endothelium more deteriorated and paw edema more severe in H-CIA than in CIA. Both groups showed clear signs of skeletal muscle atrophy and inflammation, but gastrocnemius muscle weight was lower and muscle inflammatory status worse in H-CIA than in CIA. Reduced mitochondrial function was observed only in H-CIA. Prophylactic application of 100 mg/kg lavender oil or linalyl acetate kept IL-6 levels to the normal range and reduced hind paw edema and systolic BP. Linalyl acetate 100 mg/kg was the only treatment that maintained diastolic BP and IGF-1 in their normal ranges and prevented vascular endothelial damage. These treatments also reduced inflammation of the gastrocnemius muscle and inhibited mitochondrial dysfunction while tending to increase muscle mass. Conclusions: Chronic nicotine exposure induces defects that increase the risks of cardiovascular disease and muscle weakness, and application of lavender and linalyl acetate reduced the risks, especially, linalyl acetated alleviated vascular endothelial damage along with maintained IGF-1 level. Current results encourage smokers at high risk for RA to quit smoking, and further suggest that linalyl acetate is a useful agent to prevent cardiovascular and skeletal muscle related comorbidities.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prophylactic Application of Lavandula Angustifolia Mill. Oil and Its Active Component Linalyl Acetate Alleviate Comorbidity and Exacerbation Risk in Rats With Collagen-Induced Arthritis Accompanied by Chronic Nicotine-Induced Hypertension.

Seo¹,

Hsieh²,

Lee³

et al. 2020

Preprint

Self Cite

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“…LA also modulates the expression of Endothelial NO Synthase (eNOS), preventing its suppression by ROS. This suggested a possible antihypertensive effect of LA [84,85]. In rats with hypertension induced by chronic exposure to nicotine and stress, LA (10-100 mg/kg), had a hypotensive effect [86].…”

Section: Linalyl Acetatementioning

confidence: 96%

Effects of Terpenes and Terpenoids of Natural Occurrence in Essential Oils on Vascular Smooth Muscle and on Systemic Blood Pressure: Pharmacological Studies and Perspective of Therapeutic Use

Cardoso-Teixeira¹,

Oliveira-Abreu²,

Brito³

et al. 2021

Terpenes and Terpenoids - Recent Advances

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Terpenes are a class of chemical compounds with carbon and hydrogen atoms in their structure. They can be classified into several classes according to the quantity of isoprene units present in its structure. Terpenes can have their structure modified by the addition of various chemical radicals. When these molecules are modified by the addition of atoms other than carbon and hydrogen, they become terpenoids. Terpenes and terpenoids come from the secondary metabolism of several plants. They can be found in the leaves, fruits, stem, flowers, and roots. The concentration of terpenes and terpenoids in these organs can vary according to several factors such as the season, collection method, and time of the day. Several biological activities and physiological actions are attributed to terpenes and terpenoids. Studies in the literature demonstrate that these molecules have antioxidant, anticarcinogenic, anti-inflammatory, antinociceptive, antispasmodic, and antidiabetogenic activities. Additionally, repellent and gastroprotective activity is reported. Among the most prominent activities of monoterpenes and monoterpenoids are those on the cardiovascular system. Reports on literature reveal the potential effect of monoterpenes and monoterpenoids on systemic blood pressure. Studies show that these substances have a hypotensive and bradycardic effect. In addition, the inotropic activity, both positive and negative, of these compounds has been reported. Studies also have shown that some monoterpenes and monoterpenoids also have a vasorelaxing activity on several vascular beds. These effects are attributed, in many cases to the blocking of ion channels, such as voltage-gated calcium channels. It can also be observed that monoterpenes and monoterpenoids can have their effects modulated by the action of the vascular endothelium. In addition, it has been shown that the molecular structure and the presence of chemical groups influence the potency and efficacy of these compounds on vascular beds. Here, the effect of several monoterpenes and monoterpenoids on systemic blood pressure and vascular smooth muscle will be reported.

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“…Cannabis oil affected the expression of specific airway epithelial cell genes that could modulate pro-inflammatory or Th1 processes in COPD [ 26 ]. Linalyl acetate prevented three related factors of vascular damage in COPD-like and hypertensive rats [ 27 ]. In another clinical trial, concomitant therapy with cineole reduced exacerbations as well as dyspnea and improved lung function and health status [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Essential Oils of Gardenia jasminoides J. Ellis and Gardenia jasminoides f. longicarpa Z.W. Xie & M. Okada Flowers: Chemical Characterization and Assessment of Anti-Inflammatory Effects in Alveolar Macrophage

2022

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Alveolar macrophage is the predominant cell type in the lung and is thought to be the major target for anti-inflammatory therapy in chronic obstructive pulmonary disease (COPD). Aromatherapy using natural essential oils with anti-inflammatory effects for inhalable administration is a potential complementary and alternative therapy for COPD treatment. The Gardenia jasminoides flower is famous for its fragrance in East Asia and is used for treating colds and lung problems in folk medicine. Therefore, in the present study, flower essential oils from two main medicinal gardenia varieties (G. jasminoides J. Ellis and G. jasminoides f. longicarpa Z.W. Xie & M. Okada) were extracted by hydro-distillation, and their chemical components were analyzed by GC-MS. The anti-inflammatory effects of the two essential oils and their main ingredients were further studied on lipopolysaccharide (LPS)-induced models in murine alveolar macrophages (MH-S). The results indicated that the chemical constituents of the two gardenia varieties were quite different. Alcohol accounted for 53.8% of the G. jasminoides essential oil, followed by terpenes (16.01%). Terpenes accounted for 34.32% of the G. jasminoides f. longicarpa essential oil, followed by alcohols (19.6%) and esters (13.85%). Both the two gardenia essential oils inhibited the LPS-induced nitric oxide (NO) release and reduced the production of tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) in the MH-S cells. Linalool and α-farnesene dose-dependently reduced the NO release in the MH-S cells. Linalool and α-farnesene did not affect the PGE2 production but regulated the expression of TNF- α. In addition to linalool and α-farnesene, other components in the gardenia flower essential oils appeared to be able to act as anti-inflammatory agents and influence the PGE2 pathway.

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Linalyl acetate prevents three related factors of vascular damage in COPD-like and hypertensive rats

Cited by 13 publications

References 59 publications

Prophylactic Application of Lavandula Angustifolia Mill. Oil and Its Active Component Linalyl Acetate Alleviate Comorbidity and Exacerbation Risk in Rats With Collagen-Induced Arthritis Accompanied by Chronic Nicotine-Induced Hypertension.

Prophylactic Application of Lavandula Angustifolia Mill. Oil and Its Active Component Linalyl Acetate Alleviate Comorbidity and Exacerbation Risk in Rats With Collagen-Induced Arthritis Accompanied by Chronic Nicotine-Induced Hypertension.

Effects of Terpenes and Terpenoids of Natural Occurrence in Essential Oils on Vascular Smooth Muscle and on Systemic Blood Pressure: Pharmacological Studies and Perspective of Therapeutic Use

Essential Oils of Gardenia jasminoides J. Ellis and Gardenia jasminoides f. longicarpa Z.W. Xie & M. Okada Flowers: Chemical Characterization and Assessment of Anti-Inflammatory Effects in Alveolar Macrophage

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