Linalyl acetate prevents hypertension-related ischemic injury

Hsieh, Yu Shan; Kwon, Sae-Hyuk; Lee, Hui Su; Seol, Geun Hee

doi:10.1371/journal.pone.0198082

Cited by 21 publications

(13 citation statements)

References 40 publications

(40 reference statements)

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“…Of note, evidence showed a reciprocal contribution in which LDH activity can amplify ROS generation while ROS accumulation induces LDH release due to cellular damage 59,60 . Here we showed significant reverse correlations between increasing levels of LDH activity and GSH concentration in stored PCs.…”

Section: Discussionsupporting

confidence: 52%

The effect of gamma irradiation on platelet redox state during storage

2020

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Background As a method with insignificant adverse effects on in vitro quality of platelet concentrates (PCs), gamma irradiation is applied to abrogate the risk of transfusion‐associated graft‐vs‐host disease in vulnerable recipients. However, there is some evidence of lower posttransfusion responses and proteomic alterations in gamma‐irradiated platelets (PLTs), which raises some questions about their quality, safety, and efficacy. Since reactive oxygen species (ROS) are considered as markers of PLT storage lesion (PSL), the study presented here investigated oxidant state in gamma‐irradiated PCs. Study Design and Methods PLT‐rich plasma PC was split into two bags, one kept as control while other was subjected to gamma irradiation. Within 7 days of storage, the levels of intra‐PLT superoxide, H2O2, mitochondrial ROS, P‐selectin expression, and phosphatidylserine (PS) exposure were detected by flow cytometry while intracellular reduced glutathione (GSH), glucose concentration, and lactate dehydrogenase (LDH) activity were measured by enzymocolorimetric method. Results GSH decreased, while ROS generation and LDH activity increased, during storage. Gamma irradiation significantly attenuated GSH whereas increased ROS generation in earlier and later stages of storage associated with either P‐selectin or PS exposure increments. Conclusion Gamma irradiation can significantly increase cytosolic ROS generation in two distinct phases, one upon irradiation and another later in longer‐stored PCs. While earlier ROS influx seems to be governed by direct effect of irradiation, the second phase of oxidant stress is presumably due to the storage‐dependent PLT activation. Intriguingly, these observations were also in line with early P‐selectin increments and increased PS exposure in longer‐stored PLTs. Given the mutual link between ROS generation and PLT activation, further investigation is required to explore the effect of gamma irradiation on the induction of PSL.

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Section: Discussionsupporting

confidence: 52%

The effect of gamma irradiation on platelet redox state during storage

2020

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“…Succinic acid is an active component that is applied in Jamu. Linalyl acetate prevents hypertension-related ischemic injury and can prevent the production of ROS [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

Deep Learning Approach for Predicting the Therapeutic Usages of Unani Formulas towards Finding Essential Compounds

Wijaya

Nasution

Batubara

et al. 2023

Life

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The use of herbal medicines in recent decades has increased because their side effects are considered lower than conventional medicine. Unani herbal medicines are often used in Southern Asia. These herbal medicines are usually composed of several types of medicinal plants to treat various diseases. Research on herbal medicine usually focuses on insight into the composition of plants used as ingredients. However, in the present study, we extended to the level of metabolites that exist in the medicinal plants. This study aimed to develop a predictive model of the Unani therapeutic usage based on its constituent metabolites using deep learning and data-intensive science approaches. Furthermore, the best prediction model was then utilized to extract important metabolites for each therapeutic usage of Unani. In this study, it was observed that the deep neural network approach provided a much better prediction model than other algorithms including random forest and support vector machine. Moreover, according to the best prediction model using the deep neural network, we identified 118 important metabolites for nine therapeutic usages of Unani.

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“…In addition, linalool has been demonstrated to be an antidepressant in mice [ 28 ]. Linalyl acetate has been reported to have antihypertensive properties in a hypertension-related ischaemic injury model in rodents [ 29 ] and has also been shown to induce the recovery of the acute nicotine-induced cardiovascular disruptions in rodents [ 30 ]. However, there is a lack of literature mentioning the influences of linalool, linalyl acetate, and lavender on central neurons.…”

Section: Discussionmentioning

confidence: 99%

Lavender Oil Reduces Depressive Mood in Healthy Individuals and Enhances the Activity of Single Oxytocin Neurons of the Hypothalamus Isolated from Mice: A Preliminary Study

Ogata

Ataka

Suzuki

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. The aim of the present study was to assess the effects of lavender oil inhalation on blood pressure, pulse measurements, cortisol levels, depressive mood, and anxiety in healthy male adults. The mechanism was investigated by the action on oxytocin single neurons in the hypothalamus of rodents. Methods. The participants (n = 7) were aged 20–40 years. After randomisation, they received an inhaled dose of lavender oil or distilled water for 20 min. They received the other treatment after a washout period of one week. We assessed the outcomes using the Self-Rating Depression Scale, State-Trait Anxiety Inventory, and self-rated unidimensional Visual Analogue Scale for depression; anxiety; and hunger, thirst, and appetite, respectively. Blood pressure, pulse rate, and cortisol concentration in the peripheral blood were assessed before and after inhalation. In the rodent study (n = 4), oxytocin single neurons were isolated from the mouse hypothalamus. Intracellular Ca2+ concentration in the oxytocin neurons isolated from the hypothalamus was measured following direct administration of lavender oil. Results. Seven participants completed the study. Lavender inhalation decreased Self-Rating Depression Scale score and systolic and diastolic blood pressure. Ex vivo administration of lavender oil increased intracellular Ca2+ concentration in the hypothalamic oxytocin neurons. Conclusions. Lavender oil might be a useful therapy for stress relief, and its mechanism of action may include activation of the central oxytocin neurons.

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Linalyl acetate prevents hypertension-related ischemic injury

Cited by 21 publications

References 40 publications

The effect of gamma irradiation on platelet redox state during storage

The effect of gamma irradiation on platelet redox state during storage

Deep Learning Approach for Predicting the Therapeutic Usages of Unani Formulas towards Finding Essential Compounds

Lavender Oil Reduces Depressive Mood in Healthy Individuals and Enhances the Activity of Single Oxytocin Neurons of the Hypothalamus Isolated from Mice: A Preliminary Study

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