Linalool inhibits cigarette smoke-induced lung inflammation by inhibiting NF-κB activation

Ma, Jianqun; Xu, Hai; Wu, Jun; Qu, Changfa; Sun, Feifei; Xu, Shidong

doi:10.1016/j.intimp.2015.09.005

Cited by 75 publications

(51 citation statements)

References 25 publications

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“…Studies in recent decades have demonstrated that terpenes exert anti-inflammatory effects by inhibiting various proinflammatory pathways in ear edema, bronchitis, chronic obstructive pulmonary disease, skin inflammation, and osteoarthritis (19)(20)(21)(22)(23).…”

Section: Terpenes With Anti-inflammatory Functionmentioning

confidence: 99%

“…Treatment with linalool, a natural compound found in essential oils of aromatic plants, inhibited cigarette smokeinduced acute lung inflammation by inhibiting infiltration of inflammatory cells and production of TNF-α, IL-6, IL-1β, IL-8, and monocyte chemoattractant protein -1 (MCP-1), as well as NF-κB activation (20). In another lung injury model, linalool attenuated lung histopathologic changes in LPS-induced mice.…”

Section: Terpenes With Anti-inflammatory Functionmentioning

confidence: 99%

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Terpenes from Forests and Human Health

et al. 2017

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Forest bathing has beneficial effects on human health via showering of forest aerosols as well as physical relaxation. Terpenes that consist of multiple isoprene units are the largest class of organic compounds produced by various plants, and one of the major components of forest aerosols. Traditionally, terpene-containing plant oil has been used to treat various diseases without knowing the exact functions or the mechanisms of action of the individual bioactive compounds. This review categorizes various terpenes easily obtained from forests according to their anti-inflammatory, anti-tumorigenic, or neuroprotective activities. Moreover, potential action mechanisms of the individual terpenes and their effects on such processes, which are described in various in vivo and in vitro systems, are discussed. In conclusion, the studies that show the biological effectiveness of terpenes support the benefits of forest bathing and propose a potential use of terpenes as chemotherapeutic agents for treating various human diseases.

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Section: Terpenes With Anti-inflammatory Functionmentioning

confidence: 99%

Section: Terpenes With Anti-inflammatory Functionmentioning

confidence: 99%

Terpenes from Forests and Human Health

et al. 2017

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“…bungeana [201] trans-Sabinene hydrate (64) Z. clinopodioides subsp. rigida (0.1%) [21] Antiviral (HSV-1) [282] Moderate repellent (against tick Amblyomma americanum) [305] Z. tenuior [94] Anti-inflammatory (in carrageenan-induced edema and inhibition of hyperalgesia induced by L-glutamate and prostaglandin E2 in rats) [311]; anti-inflammatory (through inhibition of the expression of TNF-α and IL-6 in LPS-stimulated RAW 264.7 cells) [312]; antiinflammatory (in cigarette smoke-induced ALI in mice through inhibiting NF-κB activation) [313] Cytotoxic (human amelanotic melanoma cell line C32, renal cell adenocarcinoma ACHN, hormone-dependent prostate carcinoma LNCaP) [314]; induction of apoptosis (variety of human leukaemia cells) [315][316][317] Hypocholesterolemic (through inhibition of HMG-CoA reductase and conversion of lanosterol to cholesterol) [318,319] Protective effect against t-BOOH induced mutagenesis [194] Review on some effects on cardiovascular system [221] Sedative and anxiolytic [320]; antidepressant [321]; GABAA receptor modulation [322] OH Z. clinopodioides subsp. rigida [21] Z. tenuior [94] p-Menth-3-en-8-ol (65)…”

Section: Ohmentioning

confidence: 99%

“…rigida [21] Z. clinopodioides subsp. rigida (12.5%) [21] Z. tenuior (53.97%) [179] Linalool ( Anti-inflammatory (in carrageenan-induced edema and inhibition of hyperalgesia induced by L-glutamate and prostaglandin E 2 in rats) [311]; anti-inflammatory (through inhibition of the expression of TNF-α and IL-6 in LPS-stimulated RAW 264.7 cells) [312]; anti-inflammatory (in cigarette smoke-induced ALI in mice through inhibiting NF-κB activation) [313] Cytotoxic (human amelanotic melanoma cell line C32, renal cell adenocarcinoma ACHN, hormone-dependent prostate carcinoma LNCaP) [314]; induction of apoptosis (variety of human leukaemia cells) [315][316][317] Hypocholesterolemic (through inhibition of HMG-CoA reductase and conversion of lanosterol to cholesterol) [318,319] Protective effect against t-BOOH induced mutagenesis [194] Review on some effects on cardiovascular system [221] Sedative and anxiolytic [320]; antidepressant [321]; GABA A receptor modulation [322] Analgesic activity reviewed [199] Review on metabolism and toxicity [200] Molecules 2016, 21, 826 20 of 53 [296]; antioxidant [273,[297][298][299] Review on some effects on cardiovascular system [221] Gastroprotective effects in the acute and chronic ulcer models in rats [300] Positive allosteric modulator of the GABAA receptors in primary cultures of mouse cortical neurons [301] Anti-hyperglycemic and anti-hyperlipidemic activity in high fat-induced type 2 diabetic C57BL/6J mice [302] and protective effect in nephropathy [303] Analgesic activity reviewed [199] Review on metabolism and toxicity [200]; general review on thyme and 62 [304] cis-Sabinene hydrate …”

Section: Ohmentioning

confidence: 99%

Kazakh Ziziphora Species as Sources of Bioactive Substances

et al. 2016

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Ziziphora species represent the prototypical example of the Lamiaceae family. The phytochemicals present in Ziziphora include monoterpenic essential oils, triterpenes and phenolic substances belonging to the flavonoids. In Kazakh traditional medicine, Ziziphora species possess several medicinal uses. In particular, Z. bungeana Lam. and Z. clinopodioides Lam. are used for the treatment of illnesses related to the cardiovascular system or to combat different infections. Unfortunately, the majority of the information about the complex Ziziphora species is only available in Russian and Chinese language, therefore, we decided gather all available information on Kazakhstan Ziziphora, namely its content compounds, medicinal uses and published patents, to draw the attention of scientists to this very interesting plant with high medicinal potential.

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“…This monoterpene has commercial importance in perfumery and cosmetics 24 Alzheimer's disease treatment 29 and protection against cigarret smoke-induced acute lung inflammation. 30 A study about the action of some essential oils against mosquitoes and ticks showed 1 and 15 as some of the major substances of essential oil of leaves of Juniperus communis L., and this oil presented activity against two species of tick and mosquito Aedes aegypti (L.).…”

mentioning

confidence: 99%

Chemical Analysis of Essential Oil and Hydrolates of Leaves, Inflorescences and Stems of Piper chimonanthifolium Kunth

Macedo

2017

Rev. Virtual Quim.

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Resumo: Plantas do gênero Piper são frequentemente utilizadas comercialmente. A espécie Piper chimonanthifolium Kunth. apresenta poucos estudos em literatura quanto a sua composição química e atividades biológicas. Óleos essenciais de outras espécies deste gênero apresentam boas atividades biológicas, principalmente contra microrganismos. Este trabalho apresenta uma comparação da composição química de óleos essenciais e hidrolatos de folhas, inflorescências e caules desta espécie. As amostras foram obtidas por co-destilação e analisadas por cromatografia com fase gasosa acoplada à espectrometria de massas (CG-EM). As amostras mostraram presença de monoterpenos e sesquiterpenos, com predominância de monoterpenos. A piperitona, um monoterpeno com atividades biológicas anteriormente relatadas na literatura, foi a substância com maior destaque. Além desta substância, destacaram-se: L-linalol, cis-β-ocimeno, trans-β-cimeno, 1-felandreno, α-pineno, limoneno e espatulenol. Algumas dessas substâncias podem exibir variação na composição de acordo com fatores ambientais e podem ser agentes de controle biológico, demonstrando importância ecológica. As análises por CG-EM evidenciaram diferenças na composição química entre folhas, inflorescências e caules, além de demonstrarem potencial biológico para esta espécie. Palavras-chave:Atividade biológica; Óleo essencial; Monoterpeno; Piperaceae; Piperitona. AbstractPlants of the genus Piper are widely used commercially. Piper chimonanthifolium Kunth. is a species with few studies on chemistry and biological activities. Essential oils of other species of this genus show good biological activities, especially against microorganisms. This work presents a comparative analysis of chemical composition of essential oils and hydrolates of leaves, inflorescences and stems of this specie. Samples were obtained by co-distillation and analyzed by gas chromatography-mass spectrometry (GC-MS). The samples were composed of monoterpenes and sesquiterpenes, with predominance of monoterpenes. Piperitone, a monoterpene with important biological activities, was the most important substance and in addition to this compound, L-linalool, cis-β-ocimene, trans-β-ocimene, 1-phellandrene, α-pinene, limonene, and spathulenol stood out. Some of these substances can exhibit a variation in the composition according to environmental factors or may be biological control agents, demonstrating ecological importance. The chemical characterization showed chemical differences between leaves, stems and inflorescences and demonstrated biological potential for this species.

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Linalool inhibits cigarette smoke-induced lung inflammation by inhibiting NF-κB activation

Cited by 75 publications

References 25 publications

Terpenes from Forests and Human Health

Terpenes from Forests and Human Health

Kazakh Ziziphora Species as Sources of Bioactive Substances

Chemical Analysis of Essential Oil and Hydrolates of Leaves, Inflorescences and Stems of Piper chimonanthifolium Kunth

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