volume 128, issue 5, P721-731 2016
DOI: 10.1182/blood-2015-11-680280
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Abstract: • Mice expressing a form of prothrombin with limited activation potential to meizothrombin are viable and are reproductively successful.• Meizothrombin directly activates platelets but has diminished positive regulation of hemostatic factor activation.Thrombin-mediated proteolysis is central to hemostatic function but also plays a prominent role in multiple disease processes. The proteolytic conversion of fII to a-thrombin (fIIa) by the prothrombinase complex occurs through 2 parallel pathways: (1)

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