We estimated health status by low health literacy and limited-English proficiency alone and in combination for Latinos, Chinese, Korean, Vietnamese, and Whites in a population-based sample: 48,427 adults from the 2007 California Health Interview Survey, including 3,715 with limited-English proficiency, were studied. Multivariate logistic models examined self-reported health by health literacy and English proficiency in the full sample and racial/ethnic subgroups. Overall, 44.9% with limited-English proficiency reported low health literacy versus 13.8% of English speakers. Among the limited-English proficient, Chinese respondents had the highest prevalence of low health literacy (68.3%), followed by Latinos (45.3%), Koreans (35.6%), Vietnamese (29.7%), and Whites (18.8%). In the full sample, respondents with both limited-English proficiency/low health literacy reported the highest prevalence of poor health (45.1%), followed by limited-English proficiency-only (41.1%), low health literacy-only (22.2%), and neither (13.8%), a hierarchy that remained significant in multivariate models. However, sub-analyses revealed limited-English proficient Latinos, Vietnamese, and Whites had equal or greater odds of poor health compared with low health literate/limited-English proficient respondents. Individuals with both limited-English proficiency and low health literacy are at high risk for poor health. Limited-English proficiency may carry greater health risk than low health literacy, though important racial/ethnic variations exist.