Limitations of non‐invasive endothelial function assessment by brachial artery flow‐mediated dilatation

Sejda, T; Piťha, Jan; Svandová, E; Poledne, R.

doi:10.1111/j.1475-097x.2004.00590.x

Cited by 38 publications

(38 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, depending on the BBAD, higher BAFMD values can be found, which does not necessarily reflect better artery function. In the present study, no significant correlations were found between BBAD and BAFMD, which agrees with the observations of Šejda et al 25 but disagrees with the results of Herrington et al 8 .…”

Section: Same Day Separate Dayssupporting

confidence: 53%

Confiabilidade da medida da dilatação fluxo-mediada da artéria braquial pela ultra-sonografia

Meirelles

Leite²,

Montenegro³

et al. 2007

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

SummaryObjective: To determine the reliability of the baseline (BBAB) and post occlusion (POBAD) brachial artery diameters, brachial artery flow-mediated dilatation (BAFMD) measurements, and to quantify the standard error of these measurements (TEM).Methods: Internal consistency (2 measurements on the same day) was determined in 10 volunteers, whereas stability (2 measurements on separate days) was determined in 13 volunteers. All the volunteers were apparently healthy and all were nonsmokers. The brachial artery images were obtained using a two dimensional Doppler ultrasound instrument equipped with a 14 MHz transducer. The distances between the intima-lumen interfaces were measured before and after the blood flow had been stopped by means of a cuff on the arm for five minutes. BAFMD was considered as the percent change of POBAD in relation to BBAD.Results: ANOVA did not identify any significant differences between the measurements taken on the same and separate days. For BAFMD, the intraclass correlation coefficients between the measurements taken on the same and separate days were: R = 0.7001 and R = 0.8420, respectively (p < 0.05). The coefficients of variation were 5.8% and 12.4% and the relative ETMs were 13.8% and 14.9%, respectively, for the measurements taken on the same and separate days. Analysis of the Bland-Altman graphs indicated that the variables did not present heteroscedastic errors. Conclusion:The BBAD, POBAD and BAFMD measurements using the manual ultrasound technique were highly reliable for both the same and separate day measurements and therefore can be used to diagnose and monitor endothelial function. (Arq Bras Cardiol 2007;89(3):160-167)

show abstract

Section: Same Day Separate Dayssupporting

confidence: 53%

Confiabilidade da medida da dilatação fluxo-mediada da artéria braquial pela ultra-sonografia

Meirelles

Leite²,

Montenegro³

et al. 2007

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

“…38,39 The variability of measurements carried out at intervals by the same operator is satisfactory, whereas the inter-observer variability is exceedingly high. 40 Accordingly, in the current study all tests were performed by the same operators in two different units, after careful training. Measured mean values were on average slightly higher than previously reported in several methodological studies, 40,41 but the young age of our population and the low prevalence of complicating diseases are a likely explanation.…”

Section: Discussionmentioning

confidence: 99%

Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease

et al. 2005

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is consistently associated with features of the metabolic syndrome, a condition carrying a high risk of cardiovascular events. We measured the vasodilatory response of the brachial artery in response to ischemia (a test of endothelial function) (FMV) as well as cardiovascular risk profile in 52 NAFLD cases and 28 age-and sex-matched controls. The 10-year risk of coronary events was calculated according to the Framingham equation and the scores derived from the PROCAM study and NCEP-ATPIII proposals. FMV was 6.33% ؎ 5.93% in NAFLD versus 12.22% ؎ 5.05% in controls (P < .0001), and higher in pure fatty liver (9.93%) compared with nonalcoholic steatohepatitis (4.94%) (P ‫؍‬ .010). No differences were observed in flow-independent vasodilation (response to sublingual nitroglycerin). Percent FMV was negatively associated with insulin resistance (homeostasis model assessment) in the whole population (r ‫؍‬ ؊0.243; P ‫؍‬ .030). In logistic regression analysis, NAFLD was associated with a percent FMV in the lower tertile (OR, 6.7; 95% CI, 1.26-36.1), after adjustment for age, sex, body mass index, and insulin resistance. Among NAFLD patients, low FMV was associated with nonalcoholic steatohepatitis (adjusted OR, 6.8; 95% CI, 1.2-40.2). The 10-year probability of cardiovascular events was moderately increased in NAFLD, and particularly in nonalcoholic steatohepatitis. In conclusion, our study provides evidence of endothelial dysfunction and increased risk of cardiovascular events in NAFLD. The risk of advanced liver disease is well recognized in NAFLD patients, but the large majority of cases might experience cardiovascular disease in the long term, indirectly limiting the burden of liver failure. (HEPATOLOGY 2005;42:473-480.)

show abstract

“…Although it is considered the current 'gold standard,' assessment of flow mediated dilatation poses several important challenges. In order to have adequate within laboratory reproducibility, administering this test requires very specialised training for the ultrasound technician, and even with extensive training, there is generally poor between laboratory reliability [33]. These limitations have meant that flow mediated dilatation has had limited clinical utility [34].…”

Section: Introductionmentioning

confidence: 99%

The research on endothelial function in women and men at risk for cardiovascular disease (REWARD) study: methodology

Bacon

Lavoie

Arsenault

et al. 2011

BMC Cardiovasc Disord

View full text Add to dashboard Cite

BackgroundEndothelial function has been shown to be a highly sensitive marker for the overall cardiovascular risk of an individual. Furthermore, there is evidence of important sex differences in endothelial function that may underlie the differential presentation of cardiovascular disease (CVD) in women relative to men. As such, measuring endothelial function may have sex-specific prognostic value for the prediction of CVD events, thus improving risk stratification for the overall prediction of CVD in both men and women. The primary objective of this study is to assess the clinical utility of the forearm hyperaemic reactivity (FHR) test (a proxy measure of endothelial function) for the prediction of CVD events in men vs. women using a novel, noninvasive nuclear medicine -based approach. It is hypothesised that: 1) endothelial dysfunction will be a significant predictor of 5-year CVD events independent of baseline stress test results, clinical, demographic, and psychological variables in both men and women; and 2) endothelial dysfunction will be a better predictor of 5-year CVD events in women compared to men.Methods/DesignA total of 1972 patients (812 men and 1160 women) undergoing a dipyridamole stress testing were recruited. Medical history, CVD risk factors, health behaviours, psychological status, and gender identity were assessed via structured interview or self-report questionnaires at baseline. In addition, FHR was assessed, as well as levels of sex hormones via blood draw. Patients will be followed for 5 years to assess major CVD events (cardiac mortality, non-fatal MI, revascularization procedures, and cerebrovascular events).DiscussionThis is the first study to determine the extent and nature of any sex differences in the ability of endothelial function to predict CVD events. We believe the results of this study will provide data that will better inform the choice of diagnostic tests in men and women and bring the quality of risk stratification in women on par with that of men.

show abstract

Limitations of non‐invasive endothelial function assessment by brachial artery flow‐mediated dilatation

Cited by 38 publications

References 20 publications

Confiabilidade da medida da dilatação fluxo-mediada da artéria braquial pela ultra-sonografia

Confiabilidade da medida da dilatação fluxo-mediada da artéria braquial pela ultra-sonografia

Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease

The research on endothelial function in women and men at risk for cardiovascular disease (REWARD) study: methodology

Contact Info

Product

Resources

About