Limitação funcional e claudicação intermitente: impacto das medidas de pressão arterial

Silva, Rita de Cassia Gengo e; Giribela, Cassiana Rosa Galvão; Wolosker, Nelson; Consolim‐Colombo, Fernanda Marciano

doi:10.1590/s0066-782x2012005000001

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…In healthy individuals, strenuous activity leads to a time-dependent increase in circulating EPCs, associated with an increased expression of the inflammatory marker IL-6, which suggests that endothelial damage could be counteracted by the release of EPCs [19]. Nitric oxide (NO) is a key molecule for EPC mobilization during physical exercise [20]. NO is one of the most important mediators released by the endothelium and acts as a potent vasodilator and inhibits inflammation, vascular wall hypertrophy, and platelet aggregation [21].…”

Section: Introductionmentioning

confidence: 99%

Previous Exercise Effects in Cisplatin-Induced Renal Lesions in Rats

Francescato

Almeida

Reis

et al. 2018

Kidney Blood Press Res

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Background/Aims: Physical training has beneficial effects on endothelial function and can influence the regeneration of the endothelial cell. We investigated the effect of physical training on cisplatin (CP)-induced acute kidney injury and assessed the impact of training on endothelial structure and function, and on the inflammatory processes in rats. Methods: We injected male Wistar rats subjected to previous physical training in treadmill running (trained, TR) or not (sedentary, SED) with CP (5 mg/kg) (TR+CP and SED+CP groups, respectively). Five days after the injections, blood and urine samples were collected to evaluate renal function and kidneys were harvested for morphological, immunohistochemical, enzyme-linked immunosorbent assay, and analysis of nitric oxide (NO) levels. Results: Rats treated with CP showed increased levels of plasma creatinine and sodium and potassium fractional excretion. These alterations were associated with increase in tubulointerstitial lesions and macrophage number, reduction of endothelial cells, and increased VEGF, vimentin, and α-smooth muscle actin expression in the outer renal medulla in the SED+CP group. We also found increased levels of renal IL-1β and increased excretion of monocyte chemoattractant protein-1 and transforming growth factor-β compared with controls. These changes were milder in trained rats, associated with increased levels of renal tissue NO, and increased expression of p-eNOS and stromal cell-derived factor-1α (a chemokine involved in kidney repair) in the kidneys of CP-injected trained rats. Conclusions: The protective effect of previous training in CP-treated rats was associated with reduced endothelial cell lesions and increased renal production of NO in trained rats.

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Section: Introductionmentioning

confidence: 99%

Previous Exercise Effects in Cisplatin-Induced Renal Lesions in Rats

Francescato

Almeida

Reis

et al. 2018

Kidney Blood Press Res

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“…EPCs were identified in culture by formation of a Colony Forming Unit (CFU) [5]. CFUs were formed after MNCs culturing for 7 days.…”

Section: Methodsmentioning

confidence: 99%

“…EPCs play an important role in vasculogenesis because of their capacity to proliferate, migrate, differentiate in vivo and in vitro into endothelial cells, and incorporate into the preexisting endothelium. Thus, phenotypically, they have morphofunctional characteristics of both hematopoietic and mature endothelial cells [5]. EPCs are rare, representing approximately 0.01%–0.0001% of the mononuclear fraction in peripheral blood.…”

Section: Introductionmentioning

confidence: 99%

Endothelial progenitor cells regenerate infracted myocardium with neovascularisation development

Aziz

Nabi

Hamid

et al. 2015

Journal of Advanced Research

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We achieved possibility of isolation, characterization human umbilical cord blood endothelial progenitor cells (EPCs), examination potency of EPCs to form new blood vessels and differentiation into cardiomyoctes in canines with acute myocardial infarction (AMI). EPCs were separated and cultured from umbilical cord blood. Their phenotypes were confirmed by uptake of double stains dioctadecyl tetramethylindocarbocyanine-labeled acetylated LDL and FITC-labeled Ulex europaeus agglutinin 1 (DILDL-UEA-1). EPCs of cord blood were counted. Human VEGFR-2 and eNOS from the cultured EPCs were assessed by qPCR. Human EPCs was transplanted intramyocardially in canines with AMI. ECG and cardiac enzymes (CK-MB and Troponin I) were measured to assess severity of cellular damage. Histopathology was done to assess neovascularisation. Immunostaining was done to detect EPCs transdifferentiation into cardiomyocytes in peri-infarct cardiac tissue. qPCR for human genes (hVEGFR-2, and eNOS) was done to assess homing and angiogenic function of transplanted EPCs. Cultured human cord blood exhibited an increased number of EPCs and significant high expression of hVEGFR-2 and eNOS genes in the culture cells. Histopathology showed increased neovascularization and immunostaining showed presence of EPCs newly differentiated into cardiomyocyte-like cells. Our findings suggested that hEPCs can mediate angiogenesis and differentiate into cardiomyoctes in canines with AMI.

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“…On the other hand, regular exercise, also known as exercise training, produces effects on the cardiovascular system and has been proven to restore endothelial function even in the presence of cardiovascular disease [ 25 ]. Regular exercise promotes changes in cholesterol levels and its subfractions; accelerates the removal of chylomicrons and low-density lipoproteins from circulation; increases the release of NO that seems to generate increased expression of eNOS [ 26 ]; increases the number of circulating EPCs in healthy individuals [ 27 ], as well as in individuals with established cardiovascular disease [ 28 ]; and improves plasma glucose [ 29 ], which has a direct link to impaired endothelial function [ 30 ]. This assumption is consistent with findings in healthy individuals [ 31 ], individuals with diabetes mellitus type 2 [ 32 ], and patients with cardiovascular conditions [ 33 ], showing that exercise training improved vascular function and overall health.…”

Section: Introductionmentioning

confidence: 99%

Study of endothelial function response to exercise training in hypertensive individuals (SEFRET): study protocol for a randomized controlled trial

Pedralli

Waclawovsky

Camacho

et al. 2016

Trials

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BackgroundEndothelial dysfunction is a hallmark of diabetes mellitus and systemic arterial hypertension (SAH) and an early maker for atherosclerosis. Aerobic exercise training is known to enhance endothelial function, but little is understood about the effects of resistance or combined exercise training on endothelial function. The aim of this study is to investigate the effect of a 12-week aerobic (AT), resistance (RT), or combined (aerobic and resistance, CT) training program on endothelial function and assess associated effects on blood pressure in individuals with SAH.Methods/designEighty-one subjects with SAH aged 18 to 70 years will be selected and randomly assigned to three types of exercise training: AT, RT or CT. The study will involve the following procedures and tests: anamnesis, anthropometric assessment, echocardiography, blood pressure measurements through ambulatory blood pressure monitoring, flow-mediated dilation, ergospirometry, one repetition maximum test (1-RM), and blood collection (number of circulating endothelial progenitor cells, number of circulating endothelial microparticles, lipid profile, glucose, glycated hemoglobin, and creatinine). The AT intervention will consist of a 40-min exercise session with progressive intensities ranging from 50 to 75 % of heart rate reserve. The RT intervention will consist of a 40-minute session with four sets of six to 12 repetitions with a rest period of 60 to 90 seconds between each set and each type of exercise. Weight loads will be adjusted to 60 to 80 % of 1-RM for six types of exercise. The CT intervention will consist of a 20-min aerobic exercise session, followed by an additional 20-min resistance exercise session; each resistance exercise will have two sets less to match the total training volume.DiscussionThe study results are expected evidence of cardiovascular protective effects of different types of exercise training through the modulation of endothelial function in hypertensive individuals. Knowing the magnitude of improvement of endothelium-dependent vasodilation for the different types of exercise training can provide scientific evidence for the prescription of exercise programs for vascular protection targeting hypertensive individuals.Trial registrationThe Brazilian Clinical Trials Registry (http://www.ensaiosclinicos.gov.br/) under RBR-9ygmdn and dated 1 March 2015.

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Limitação funcional e claudicação intermitente: impacto das medidas de pressão arterial

Cited by 8 publications

References 25 publications

Previous Exercise Effects in Cisplatin-Induced Renal Lesions in Rats

Previous Exercise Effects in Cisplatin-Induced Renal Lesions in Rats

Endothelial progenitor cells regenerate infracted myocardium with neovascularisation development

Study of endothelial function response to exercise training in hypertensive individuals (SEFRET): study protocol for a randomized controlled trial

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