Limb remote ischemic postconditioning protects integrity of the blood-brain barrier after stroke

Li, Juan; Hu, Xiaosong; Zhou, Fangfang; Li, Shuai; Lin, Yenn‐Jiang; Qi, Wen-Qian; Qi, Cunfang; Zhang, Xiao

doi:10.4103/1673-5374.237122

Cited by 20 publications

(15 citation statements)

References 54 publications

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“…Focal cerebral ischemia was induced by the unilateral filament middle cerebral artery occlusion (MCAO) model in the majority of studies (Table 1 ). 1 , 2 , 3 , 10 , 11 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 The duration of MCAO (and thus size of induced lesions) varied from 30 to 120 min, with 60 2 , 18 , 23 , 24 , 26 , 27 , 28 or 90 1 , 15 , 16 , 20 , 21 , 25 , 29 min of occlusion being the most common duration. Only two studies used the MCAO embolic model (embolic stroke is induced by the injection of a homologous blood clot into the middle cerebral artery).…”

Section: Resultsmentioning

confidence: 99%

“…Only two studies used the MCAO embolic model (embolic stroke is induced by the injection of a homologous blood clot into the middle cerebral artery). 30 , 31 Anesthetics were used during MCAO in all studies; most used chloral hydrate, 17 , 18 , 19 , 20 , 21 , 25 , 26 , 27 , 28 eight used isoflurane, 1 , 3 , 10 , 11 , 22 , 23 , 24 , 30 and two used the structural isomer enflurane. 2 , 29 One study used isoflurane and halothane during the MCAO to determine if either had additional effects on the outcomes of RIPostC.…”

Section: Resultsmentioning

confidence: 99%

“… 24 The remaining 13 studies using RIPostC did not disclose whether RIC procedures were carried out, while animals were under additional use of anesthesia or if the control groups were exposed to similar doses and durations of anesthesia. 1 , 2 , 10 , 11 , 18 , 19 , 20 , 21 , 23 , 25 , 26 , 27 , 28 …”

Section: Resultsmentioning

confidence: 99%

“…Likewise, one study claimed to investigate RIPostC but initiated RIC just before reperfusion, thereby almost resembling RIPerC. 19 Almost all the 16 RIPostC protocols initiated RIC immediately after reperfusion 2 , 10 , 11 , 18 , 19 , 20 , 25 , 26 , 27 , 28 , 31 ; only five protocols delayed the RIPostC. 1 , 21 , 22 , 23 , 24 Variations in the protocol of delayed RIPostC studies disallowed a direct comparison.…”

Section: Resultsmentioning

confidence: 99%

“…RIC was mainly applied on hindlimbs, either on one limb 1 , 3 , 11 , 17 , 19 , 22 , 25 , 30 or more commonly bilaterally. 2 , 10 , 15 , 16 , 18 , 20 , 23 , 24 , 26 , 27 , 28 , 29 One study did not reveal the number of limbs subjected to RIC. 21 Effects of RIC applied on unilateral, bilateral, and multiple limbs were also compared to explore differences in the efficacy of RICs based on the number of RIC‐affected limbs.…”

Section: Resultsmentioning

confidence: 99%

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Translational challenges of remote ischemic conditioning in ischemic stroke – a systematic review

Hansen

Nielsen

Christoffersen

et al. 2021

Ann Clin Transl Neurol

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Remote ischemic conditioning (RIC) has well‐established cardioprotective effects in preclinical studies and promising results in preclinical stroke research. Effective translation from preclinical studies to clinical trials has yet to be accomplished, perhaps because of the use of multiple applications of RIC (e.g., pre‐, per‐, or post‐conditioning) in preclinical studies by both invasive and non‐invasive protocols, some of which not clinically applicable. Our systematic review conformed to PRISMA guidelines and addressed differences in clinically relevant RIC applications and outcomes between preclinical and clinical studies. We retrieved a total of 30 studies (8 human; 22 animal) that met the inclusion criteria of testing clinically relevant procedures; namely, non‐invasive and per‐ or post‐conditioning protocols. Per‐conditioning was applied in 6 animal and 3 human studies, post‐conditioning was applied in 16 animal and 5 human studies, and both conditioning methods were applied in 2 animal studies. Application of RIC varied between human and animal studies regarding initiation, duration, repetition, and number of limbs included. Study designs did not systematically apply blinding, randomization, or placebo controls. On only a few occasions did preclinical studies include animals with clinically relevant comorbidities. Clinical trials were challenged by not completing the intended number of RIC cycles or addressing this deficit in the data analysis. Consistency and transferability of methods used for positive animal studies and subsequent human studies are essential for the optimal translation of results. Consensus on preclinical and clinical RIC procedures should be reached for a full understanding of the possible beneficial effects of RIC treatment in stroke.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Translational challenges of remote ischemic conditioning in ischemic stroke – a systematic review

Hansen

Nielsen

Christoffersen

et al. 2021

Ann Clin Transl Neurol

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The neuroprotective effect and RNA‐sequence analysis of postconditioning on the ischemic stroke with diabetes mellitus tree shrew model

et al. 2021

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Introduction:Patients with comorbidity of ischemic stroke (IS) and diabetes mellitus (DM) show poor neurological functional recovery, and ischemic postconditioning (IPOC) should be considered a powerful neuroprotective method for IS. However, whether it should be introduced for patients with IS and DM remains controversial.This study established a DM with IS (DMIS) tree shrew model, which was intervened by IPOC to assess its neuroprotective effects and also to analyze the relevant mechanism by RNA-sequence and bioinformatics analysis.Methods: Fifty-four tree shrews were randomly divided into a sham operation control group, a DMIS group, and an IPOC group (DMIS model), with 18 tree shrews per group. Triphenyl tetrazolium chloride (TTC), hematoxylin-eosin (HE) staining, transmission electron microscopy (TEM), and RNA-sequence analysis were performed to assess the IPOC effect.Results: IPOC reduced infarct size and reduced nerve cell injury in IS tree shrews with DM. RNA-seq analysis showed that IPOC significantly increased the expression of the homeobox protein SIX3, while downregulating the expression of HLA class II histocompatibility antigens DQ beta 1 chain, CAS1 domain-containing protein 1, and cytokine receptor-like factor 2. The most downregulated signaling pathways include the NF-κB signaling pathway, TNF signaling pathway, and Fc gamma R-mediated phagocytosis. Conclusions:IPOCs have a neuroprotective effect in a DMIS animal model that reduces infarct size and nerve cell injury. This mechanism might be related to reducing inflammation and stress responses that decreases the activity of TNF and NF-κB signaling pathways.

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Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6‐mediated matrix metalloproteinase 9

Pai

Hsu

Hsieh

et al. 2020

Food Science & Nutrition

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Metastasis is the crucial mechanism to cause high mortality in lung cancer. Degradation of extracellular matrix (ECM) by proteolytic enzymes, especially matrix metalloproteinases (MMPs), is a key process for promoting cancer cell migration and invasion. Therefore, targeting MMPs might be a strategy for lung cancer metastasis suppression. Honokiol, a biological active component of Magnolia officinalis, has been indicated to suppress lung cancer tumorigenesis through epigenetic regulation. However, the regulation of MMPs‐mediated migration and invasion by honokiol through epigenetic regulation in lung cancer is still a mystery. In the present study, the migration and invasion ability of H1299 lung cancer was suppressed by noncytotoxic concentrations of honokiol treatment. The proteolytic activity of MMP‐9, rather than MMP‐2, was inhibited in honokiol‐treated H1299 cells. Honokiol‐inhibited MMP‐9 expression was through promoting MMP‐9 protein degradation rather than suppressing transcription mechanism. Furthermore, the expression of specific histone deacetylases 6 (HDAC6) substrate, acetyl‐α‐tubulin, was accumulated after honokiol incubation. The disassociation of MMP‐9 with hyper‐acetylated heat shock protein 90 (Hsp90) was observed resulting in MMP‐9 degradation after honokiol treatment. Meanwhile, honokiol‐suppressed MMP‐9 expression and invasion ability of H1299 lung cancer cells was rescued by HDAC6 overexpression. Accordingly, the results suggested that the suppression of migration and invasion activities by honokiol was through inhibiting HDAC6‐mediated Hsp90/MMP‐9 interaction and followed by MMP‐9 degradation in lung cancer.

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Limb remote ischemic postconditioning protects integrity of the blood-brain barrier after stroke

Cited by 20 publications

References 54 publications

Translational challenges of remote ischemic conditioning in ischemic stroke – a systematic review

Translational challenges of remote ischemic conditioning in ischemic stroke – a systematic review

The neuroprotective effect and RNA‐sequence analysis of postconditioning on the ischemic stroke with diabetes mellitus tree shrew model

Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6‐mediated matrix metalloproteinase 9

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