LIM-kinase 1 effects on memory abilities and male courtship song in Drosophila depend on the neuronal type
A. V. Zhuravlev,
E. S. Zalomaeva,
E. S. Egozova
et al.
Abstract:The signal pathway of actin remodeling, including LIM-kinase 1 (LIMK1) and its substrate cofilin, regulates multiple processes in neurons of vertebrates and invertebrates. Drosophila melanogaster is widely used as a model object for studying mechanisms of memory formation, storage, retrieval and forgetting. Previously, active forgetting in Drosophila was investigated in the standard Pavlovian olfactory conditioning paradigm. The role of specific dopaminergic neurons (DAN) and components of the actin remodeling… Show more
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