Light-Sensitive Eruptions in American Indians

Everett, Mark Allen

doi:10.1001/archderm.1961.01580080073008

Cited by 34 publications

(5 citation statements)

References 4 publications

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“…PLE can affect all races and skin types, although it appears more frequently in fair‐skinned individuals; in fact it has been reported also in black and Oriental people, and American Indians 9,10 . Women are affected two to three times more often than males, although some investigators have reported an even higher female to male ratio (7 : 1) 5,11,12 .…”

Section: Epidemiologymentioning

confidence: 99%

Polymorphous light eruption

Stratigos

Antoniou

Katsambas

2002

Acad Dermatol Venereol

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Polymorphous light eruption (PLE) is a common idiopathic photosensitivity disorder with an estimated prevalence of 10-20%. It is characterized by an intermittent skin reaction to ultraviolet (UV) radiation exposure, consisting of non-scarring pruritic erythematous papules, vesicles or plaques that develop on light-exposed skin. Despite the different morphology in different individuals, the eruption tends to have a monomorphous presentation in any single subject. The histopathological features of PLE are distinct and comprise a perivascular lymphocytic infiltrate in the dermis, subepidermal oedema and variable epidermal changes. The pathogenesis of PLE is not well known, but findings suggest that it is a delayed-type hypersensitivity reaction to one or more UV-modified cutaneous antigens. The principal action of PLE is mainly in the UVA region, although some subjects exhibit sensitivity to UVB alone or to both UVA and UVB radiation at the same time. Preventive measures in PLE include the regular use of photoprotective methods combined with graduated exposures to natural sunlight. The induction of immune tolerance by phototherapy and photochemotherapy are useful prophylactic methods in moderate to severe cases. The role of systemic agents in the management of PLE is under investigation. This article reviews the epidemiological, pathogenetic and clinical aspects of PLE and discusses recent advances in the diagnostic approach and management of this condition.

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Section: Epidemiologymentioning

confidence: 99%

Polymorphous light eruption

Stratigos

Antoniou

Katsambas

2002

Acad Dermatol Venereol

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“…However, it has only recently been recognized as identical to the condition described under many names in North, Central and South America. These include photodermatitis in North American Indians: familial actinic prurigo (Birt & Davis, 1968;Everett et al, 1961); syndrome cutaneo guatamalense (Cordero, i960;1976); familial actinic prurigo (Jonquieras, 1973;Londono et al, 1966;Londono, I973)j and prurigo solar de altiplanicie (Flores, 1975).…”

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confidence: 99%

Actinic prurigo (Hutchinson's summer prurigo)

Calnan

Meara

1977

Clin Exp Dermatol

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Summary Actinic prurigo or Hutchinson's summer prurigo is an entirely separate disease from polymorphic light eruption. The former is especially common in Mexico, Central and South America, while the latter is common in Europe. The differences between the two conditions are enumerated. It is emphasized that actinic prurigo is a chronic persistent and recalcitrant eruption which often continues throughout the winter months and affects covered as well as exposed areas of skin. A personal series of 51 patients with actinic prurigo is presented. The efficacy of thalidomide in the treatment of some cases of actinic prurigo is confirmed.

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“…The presence of a hereditary form of polymorphous light eruption (HPLE) was reported among North American Indians by Schenck, 1 Everett et al , 2 and Birt and Davi s. 3 The same condition has been reported by Londono et al 4 among the indians oi Colombia, South America. This paper reports the occurrence oi HPLE in 12 Inuit patients from Rankin Inlet in the Canadian Northwest Territories.…”

mentioning

confidence: 72%

“…5 • 6 All 12 patients had lesions affecting the sun-exposed areas of the face (Figs. [2][3][4]. Five patients showed involvement of the dorsum of the hands and two were affected on the sun-exposed areas of the forearms during the summer months.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Hereditary Polymorphic Light Eruption in Canadian Inuit

Orr¹,

Birt²

1984

Int J Dermatology

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Twelve Canadian Inuit patients from the Keewatin District of the Northwest Territories were found to have hereditary polymorphic light eruption. The clinical manifestations were similar to those described in the North American Indian, with a photodermatitis occurring in the sunlight-exposed area. The onset occurred prior to the age of 15 years in 70% of subjects, and the condition was seasonally recurrent, starting in February and lasting until September. Patients demonstrated improvement on a combined regime of local therapy and oral trioxalen. Seventy-five percent of patients had a family history of photosensitivity, suggesting an autosomal dominant trait with incomplete penetrance. Indian ancestry was not demonstrated in these patients.

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Light-Sensitive Eruptions in American Indians

Cited by 34 publications

References 4 publications

Polymorphous light eruption

Polymorphous light eruption

Actinic prurigo (Hutchinson's summer prurigo)

Hereditary Polymorphic Light Eruption in Canadian Inuit

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