Lifestyle modification decreases the mean platelet volume in prehypertensive patients

Yazıcı, Mehmet; Kaya, Ahmet; Kaya, Yasemın; Albayrak, Sinan; Cinemre, Hakan; Özhan, Hakan

doi:10.1080/09537100802613449

Cited by 57 publications

(52 citation statements)

References 34 publications

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“…However, in HT patients, both estimated parameters were significantly higher than in healthy controls, but only MPV levels significantly exceeded those observed in the PH group. Our results differ from those in the report by Yazici et al [50], who found increased MPV in pre-hypertensive subjects. However, the MPV in PH patients in their report was similar to our results, but the values of MPV were significantly lower in healthy controls.…”

Section: Discussioncontrasting

confidence: 57%

High-sensitivity C-reactive protein and mean platelet volume in paediatric hypertension

et al. 2010

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The purpose of the study was to investigate serum uric acid (SUA), high-sensitivity C-reactive protein (hs-CRP) and mean platelet volume (MPV) in pre-hypertensive (PH) and hypertensive (HT) children and adolescents. The study group consisted of 80 patients aged 10-19 years subdivided into PH and HT groups according to mean daytime or night-time systolic or diastolic blood pressure (BP) levels (> 90th percentile, but < 95th percentile and > or = 95th percentile, respectively). The control group (C) contained 25 normotensive subjects. Serum hs-CRP level was determined by a nephelometric method (Behring); platelets (PLTs) were counted, and MPV was assessed by a Coulter Analyzer MAXM. SUA was measured with an Hitachi instrument. The median SUA and hs-CRP levels in PH and HT subjects were significantly higher than those of the controls (P < 0.01) and were higher in the HT group than in the PH group (P < 0.05). An increase in SUA above 5.5 mg/dl was associated with an increase in hs-CRP [odds ratio (OR) 4.8; confidence interval (CI) 1.3-17.4; P < 0.01]. MPV values in the PH group did not differ from those of the controls (P > 0.05), but it was significantly higher in HT patients (P < 0.01). Serum hs-CRP and MPV concentrations were positively correlated with all BP measurements except night-time diastolic blood pressure (DBP). We demonstrated that, in HT children and adolescents, increased SUA with a parallel increase in hs-CRP and PLTs with MPV is observed. Although large, multicentre, prospective studies are needed to confirm this observation, hyperuricaemia seems to be associated with an increase in hs-CRP in PH and HT patients.

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Section: Discussioncontrasting

confidence: 57%

High-sensitivity C-reactive protein and mean platelet volume in paediatric hypertension

et al. 2010

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“…The hypothesis of a causal association between platelet activation and prehypertension is supported by the evidence from intervention trials, suggesting a significant increase in MPV in prehypertensive subjects; these trials also showed a decrease in MPV after lifestyle modification for 20 weeks in a small sample of patients. 33 Further, prospective studies on the longitudinal association between MPV in relation to changes in blood pressure and prehypertension will help elucidate the true nature and magnitude of the association. Second, our study took place in a single center from a large urban teaching hospital, and the study population was a relatively homogeneous population in which a number of risk factors had been excluded.…”

Section: Discussionmentioning

confidence: 99%

Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

et al. 2012

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Mean platelet volume (MPV), an indicator of platelet activation, has been shown to be elevated in patients with hypertension. However, data available on the association between MPV level and prehypertension are limited. Prehypertension is also associated with an increase in cardiovascular morbidity and mortality. A cross-sectional study was performed among 80 545 standardized medical checkup participants X18 years in age without hypertension or diabetes in China between April 2009 and May 2010. Blood pressure was categorized as prehypertensive (systolic blood pressure, 120-140 mm Hg and/or diastolic blood pressure, 80 to 90 mm Hg, n ¼ 36 586) and normotensive (systolic blood pressure, o120 mm Hg and diastolic blood pressure, o80 mm Hg, n ¼ 43 959). Mean systolic blood pressure and the prevalence of prehypertension increased significantly with increasing MPV. After adjusting for demographics, body mass index, smoking and serum cholesterol, the odds ratio for prehypertension, when comparing the highest category of MPV (412.0 fl) with the lowest category (o10.1 fl), was 1.08 (95% confidence interval, 1.02-1.13; P for trend ¼ 0.014). This association persisted in separate analysis among men but not among women. In nonparametric models, the positive association between MPV and prehypertension appeared to be present across the full range of MPV, without any threshold effect. Increased MPV is associated with prehypertension in a large sample of Chinese adults that are free of cardiovascular disease and hypertension.

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“…As the association of these variables was mainly directed towards a risk profile for cardiovascular disease, such an association might become stronger in pathological conditions, such as diabetes, obesity and hypertension. [35][36][37] Environmental variables, including dietary habits, did not show any relevant association with platelet indices.…”

Section: Other Variablesmentioning

confidence: 99%

White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

Santimone¹,

Castelnuovo²,

Curtis³

et al. 2011

Haematologica

155

100

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The online version of this article has a Supplementary Appendix. BackgroundThe understanding of non-genetic regulation of platelet indices -platelet count, plateletcrit, mean platelet volume, and platelet distribution width -is limited. The association of these platelet indices with a number of biochemical, environmental and clinical variables was studied in a large cohort of the general population. Design and MethodsMen and women (n=18,097, 52% women, 56±12 years) were randomly recruited from various villages in Molise (Italy) in the framework of the population-based cohort study "Moli-sani". Hemochromocytometric analyses were performed using an automatic analyzer (Beckman Coulter, IL, Milan, Italy). Associations of platelet indices with dependent variables were investigated by multivariable linear regression analysis. ResultsFull models including age, sex, body mass index, blood pressure, smoking, menopause, white and red blood cell counts, mean corpuscular volume, D-dimers, C-reactive protein, high-density lipoproteins, low-density lipoproteins, triglycerides, glucose, and drug use explained 16%, 21%, 1.9% and 4.7% of platelet count, plateletcrit, mean platelet volume and platelet distribution width variability, respectively; variables that appeared to be most strongly associated were white blood cell count, age, and sex. Platelet count, mean platelet volume and plateletcrit were positively associated with white blood cell count, while platelet distribution width was negatively associated with white blood cell count. Platelet count and plateletcrit were also positively associated with C-reactive protein and D-dimers (P<0.0001). Each of the other variables, although associated with platelet indices in a statistically significant manner, only explained less than 0.5% of their variability. Platelet indices varied across Molise villages, independently of any other platelet count determinant or characteristics of the villages. ConclusionsThe association of platelet indices with white blood cell count, C-reactive protein and Ddimers in a general population underline the relation between platelets and inflammation.Key words: platelet, inflammation, C-reactive protein, white blood cells, age, gender. Citation: Santimone I, Di Castelnuovo A, De Curtis A, Spinelli M, Cugino D, Gianfagna F, Zito F, Donati MB, Cerletti C, de Gaetano G and Iacoviello L on behalf of the Moli-sani ProjectInvestigators.White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project. Haematologica 2011;96(8):1180-1188. doi:10.3324/haematol.2011 This is an open-access paper.White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

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Lifestyle modification decreases the mean platelet volume in prehypertensive patients

Cited by 57 publications

References 34 publications

High-sensitivity C-reactive protein and mean platelet volume in paediatric hypertension

High-sensitivity C-reactive protein and mean platelet volume in paediatric hypertension

Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

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