Lifestyle and Chronic Constipation in Medical Students

Yıldırım, Mehmet Aykut; Çakır, Murat; Biçer, Mehmet; Şentürk, Mustafa; Yonar, Harun; Gur, Merve Nur; Akiner, Zeliha Nur; Guldiken, Ayse; Karagül, Hilal; Ceri, Bugra

doi:10.1155/2021/4752614

Cited by 8 publications

(7 citation statements)

References 6 publications

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“…Other experimental research too, showed that there was association between stress and constipation. [43] In contrast, this study showed a different result. A probable reason is that the ROME IV criteria used as constipation diagnosis might limiting and narrowing the definition of constipation, so that the result do not show any association.…”

Section: Discussioncontrasting

confidence: 75%

Association between Online Study Stress in COVID-19 Pandemic with Constipation

Abdillah¹

2022

SCRIPTA SCORE Sci Med J.

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Background: Constipation is common and affects 15% of population worldwide. Constipation can decrease the quality of life of the patients and may be affected by many factors, including stress. Stress too, is general, especially in students, causing higher rates in suicidal tendency and impairments from various aspects. Today, in COVID-19 pandemic, stress is more common due to numerous causes. One of the causes is online studying in COVID-19 pandemic, which might trigger stress in students. Objectives: To determine the relationship between online study stress in COVID-19 pandemic with constipation in the year 2018 medical students of USU in 2021. Method: This study is an analytical observational study using a cross-sectional design. Samples in this study were 112-year 2018 medical students of USU who satisfied the inclusion criteria and gathered by using a consecutive sampling method. Primary data were acquired by using an online- shared questionnaire in the google form and submitted by the respondents. Then, univariate, and bivariate analyses were performed on the data using SPSS, with the latter using fisher’s exact test. Results: In this study, 78 students (69,6%) were stressed and 8 students (7,1%) were constipated. The analysis between the two variables using fisher’s exact test shown the p value about 0,431, which can be interpreted as no association found between online study stress in COVID-19 pandemic with constipation. Conclusion: Online study stress in COVID-19 pandemic is not associated with constipation. Keywords: Constipation, Pandemic, Online study, Stress

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Section: Discussioncontrasting

confidence: 75%

Association between Online Study Stress in COVID-19 Pandemic with Constipation

Abdillah¹

2022

SCRIPTA SCORE Sci Med J.

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“…Increased stress causes differences in gastrointestinal system habits 21 . Constipation has been associated with stress in some studies; however, the rate of constipation was not significantly increased in the group of individuals who stated an increased stress with isolation in this present study 18,22 . The effects of acute and chronic stress on intestinal function may vary.…”

Section: Discussioncontrasting

confidence: 66%

Constipation in the period of limited isolation during COVID-19 pandemic

Kayaoğlu

Sert

2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: COVID-19 outbreak has become widespread globally and caused a new global chaos. This outbreak that completely affected the lifestyle of individuals resulted in periods of isolation. Here, we evaluated the effects of lifestyle changes with isolation on constipation. METHODS: A survey on constipation was performed during the 12-week isolation period starting in March 2020 in Turkey. Data of 390 individuals who participated in the survey through the social media and who were actively employed prior to isolation were analyzed. Rome IV criteria were used to evaluate constipation. RESULTS: Among the participants in the study, 253 (64.9%) were women with the mean age of 39.5±9.5 years. A statistically significant association was found between the decreased water consumption during the isolation period and constipation after the isolation (p=0.020; p<0.05). A significant association was found between the changes in physical activity and constipation after the isolation (p=0.013; p<0.05). New development of constipation during the isolation or declaration of increased constipation was found to be statistically associated with post-isolation constipation according to Rome criteria (p=0.000; p<0.05). CONCLUSION:The data of this present study demonstrated that isolation period was effective on the newly developed constipation. Decreased physical activity and water consumption are also effective on constipation.

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“…Chronic constipation has a global prevalence of 15% and is one of the most common gastrointestinal diagnoses in outpatient medical clinics [18].Chronic constipation is a common type of digestive system disease, manifested as increased frequency of defecation, di culty in defecation and tension [19]. STC is a movement disorder with a signi cant decrease in total ITR [20].…”

Section: Discussionmentioning

confidence: 99%

Wenyang Yiqi Formula improves Na + /H + ion transport by inhibiting NHE3 via activation of gastrin/CCKBR pathway

Wang

et al. 2023

Preprint

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Background: STC is a common digestive disorder and WYF is a Chinese medicine used to treat it. NHE3 is a protein that helps absorb sodium ions and its inhibition has been linked to various diarrheal diseases. There is little research on the effects of WYF on NHE expression and the treatment of STC, and the mechanism behind it is not understood. Objective: This study aimed to investigate the effects of the WYF on Na+/H+ ion transport in vivo and in vitro and to uncover the mechanism of the WYF in treating STC. Methods: The effectiveness of WYF in treating STC was tested on rats with induced STC and Caco-2 cells in a laboratory setting. The study compared the impact of WYF on several factors, including the rate of intestinal transit, colon tissue pathology, characteristics of feces, and stool volume among five groups (n=6/group). The researchers also evaluated the effects of WYF on cell viability, NHE3 activity and expression, and markers in two signaling pathways (gastrin/CCKBR and PI3K/PLC/PKC). Results: WYF improved the rate of intestinal transit and colon tissue pathology in STC rats, and reduced cell viability and NHE3 activity and expression in Caco-2 cells. The concentration of gastrin and the level of CCKBR increased with WYF treatment, while NHE3 activity had opposite trends in response to WYF and the sh-CCKBR group. Adding gastrin reversed these effects in the sh-CCKBR group. The activity of NHE3 was decreased in the WYF (20%)+gastrin (300 nmol) group, but significantly upregulated in the sh-CCKBR group with or without serum containing 20% WYF, which was reversed after adding gastrin. The ratios of p-PI3K to PI3K, p-PLC to PLC, and p-PKC to PKC in the serum containing 20% WYF were significantly increased, but decreased in the LY294002 group. After adding serum containing WYF, the reduction of these ratios was reversed. The activity of NHE3 had opposite trends to the ratios of p-PI3K to PI3K, p-PLC to PLC, and p-PKC to PKC. Conclusion: The WYF can be used to treat STC, possibly by improving Na+/H+ ion transport through inhibiting NHE3, activating the gastrin/CCKBR pathway, and PI3K/PLC/PKC-dependent pathways.

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Lifestyle and Chronic Constipation in Medical Students

Cited by 8 publications

References 6 publications

Association between Online Study Stress in COVID-19 Pandemic with Constipation

Association between Online Study Stress in COVID-19 Pandemic with Constipation

Constipation in the period of limited isolation during COVID-19 pandemic

Wenyang Yiqi Formula improves Na + /H + ion transport by inhibiting NHE3 via activation of gastrin/CCKBR pathway

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