2005
DOI: 10.1111/j.1474-9726.2005.00168.x
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Abstract: SummaryCaenorhabditis elegans expresses a glutathione transferase (GST) belonging to the Pi class, for which we propose the name CeGSTP2-2. CeGSTP2-2 (the product of the gst-10 gene) has the ability to conjugate the lipid peroxidation product 4-hydroxynonenal (4-HNE). Transgenic C. elegans strains were generated in which the 5′ ′ ′ ′ -flanking region and promoter of gst-10 were placed upstream of gst-10 and mGsta4 cDNAs, respectively. mGsta4 encodes the murine mGSTA4-4, an enzyme with particularly high catalyt… Show more

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Cited by 90 publications
(105 citation statements)
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References 69 publications
(80 reference statements)
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“…Therefore, the interaction between HHIP and GSTP1 in the cellular mitochondrial fraction suggests that HHIP may reduce oxidative stress by binding to and possibly increasing the activity of GSTP1. Interestingly, overexpressing GSTP1 in Caenorhabditis elegans extended its lifespan (39), suggesting a potential antiaging role of GSTP1, consistent with reduced GSTP1 activity in Hhip +/− mice.…”
Section: Hhip Interacts With Gstp1 and Enhances Glutathione-conjugatingmentioning
confidence: 69%
“…Therefore, the interaction between HHIP and GSTP1 in the cellular mitochondrial fraction suggests that HHIP may reduce oxidative stress by binding to and possibly increasing the activity of GSTP1. Interestingly, overexpressing GSTP1 in Caenorhabditis elegans extended its lifespan (39), suggesting a potential antiaging role of GSTP1, consistent with reduced GSTP1 activity in Hhip +/− mice.…”
Section: Hhip Interacts With Gstp1 and Enhances Glutathione-conjugatingmentioning
confidence: 69%
“…Cognate observations have led to the proposal that enhanced detoxification processes could act as an evolutionarily conserved mechanism for lifespan extension (12,13,15,34). Indeed, there is evidence from both worms and flies that enhanced expression of GST-encoding genes can increase longevity (35,36). These findings led us to investigate whether experimentally enhancing xenobiotic detoxification could also promote longevity.…”
Section: Discussionmentioning
confidence: 99%
“…Different letters above the bar indicate significant differences, according to P<0.01 in SAS GSTO-1 promoter experienced transcriptional upregulation of GSTO-1 under pro-oxidant stress, which subsequently led to an increase in stress resistance in the worms (Burmeister et al 2008). In particular, the overexpression of C. elegans GSTP2-2 in transgenic worms was found not only to lead to resistance to paraquat, heat shock, UV radiation, and hydrogen peroxide but also to an increased median lifespan (Ayyadevara et al 2005). Therefore, an increase in AccGSTS1 expression under various abiotic stresses may protect honey bees from ROS damage to ensure survival and may represent an adaptive response against oxidative stress.…”
Section: Tissue and Stage-specific Expression Profiles Of Accgsts1mentioning
confidence: 99%
“…They can catalyze the conjugation of the reduced glutathione (GSH) to electrophilic centers of a wide range of exogenous or endogenous toxic compounds, including cancer chemotherapeutic agents, chemical carcinogens, insecticides, herbicides, and oxidative stress products (Hayes et al 2005). Some members also manifest glutathione peroxidase activity and promote the metabolism of organic hydroperoxides generated in cells (Ayyadevara et al 2005;Burmeister et al 2008;Singh et al 2001;Tang and Tu 1994). As modulated expression levels of GST under oxidative stress are thought to represent Electronic supplementary material The online version of this article (doi:10.1007/s12192-012-0394-7) contains supplementary material, which is available to authorized users.…”
Section: Introductionmentioning
confidence: 99%