Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases

Gassen, Nils C.; Chrousos, George P.; Binder, Elisabeth B.; Zannas, Anthony S.

doi:10.1016/j.neubiorev.2016.06.003

Cited by 104 publications

(85 citation statements)

References 144 publications

(203 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, research among African‐American children found that supportive family contexts were protective for children against the effects of racial discrimination on EAA (Brody, Yu, Chen, Beach, & Miller, ). Notably, glucocorticoid signaling has been proposed as one mechanism linking psychosocial adversity to increased EAA (Davis et al, ; Gassen, Chrousos, Binder, & Zannas, ; Zannas et al, ). However, glucocorticoids, such as cortisol, likewise play metabolic roles and are elevated in energetically stressed children (Freemark, ; Sapolsky, Romero, & Munck, ).…”

Section: Introductionmentioning

confidence: 99%

Epigenetic aging in children from a small‐scale farming society in The Congo Basin: Associations with child growth and family conflict

Gettler

Lin

Miegakanda

et al. 2019

Developmental Psychobiology

View full text Add to dashboard Cite

Developmental environments influence individuals' long‐term health trajectories, and there is increasing emphasis on understanding the biological pathways through which this occurs. Epigenetic aging evaluates DNA methylation at a suite of distinct CpG sites in the genome, and epigenetic age acceleration (EAA) is linked to heightened chronic morbidity and mortality risks in adults. Consequently, EAA provides insights on trajectories of biological aging, which early life experiences may help shape. However, few studies have measured correlates of children's epigenetic aging, especially outside of the U.S. and Europe. In particular, little is known about how children's growth and development relate to EAA in ecologies in which energetic and pathogenic stressors are commonplace. We studied EAA from dried blood spots among Bondongo children (n = 54) residing in a small‐scale, fisher‐farmer society in a remote region of the Republic of the Congo. Here, infectious disease burdens and their resultant energy demands are high. Children who were heavier for height or taller for age, respectively, exhibited greater EAA, including intrinsic EAA, which is considered to measure EAA internal to cells. Furthermore, we found that children in families with more conflict between parents had greater intrinsic EAA. These results suggest that in contexts in which limited energy must be allocated to competing demands, more investment in growth may coincide with greater EAA, which parallels findings in European children who do not face similar energetic constraints. Our findings also indicate that associations between adverse family environments and greater intrinsic EAA were nonetheless observable but only after adjustment for covariates relevant to the energetically and immunologically demanding nature of the local ecology.

show abstract

Section: Introductionmentioning

confidence: 99%

Epigenetic aging in children from a small‐scale farming society in The Congo Basin: Associations with child growth and family conflict

Gettler

Lin

Miegakanda

et al. 2019

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

“…In recent years, the role of stress mediators in the liver pathophysiology has gained a new dimension [8, 10, 11]. Deviant increase in glucocorticoids following stress-arousal influences both food consumption and energy expenditure [12, 13]. Studies in human subjects strongly suggest a correlation between prolonged elevation of circulating glucocorticoids and weight gain [14].…”

Section: Introductionmentioning

confidence: 99%

Psychosocial-Stress, Liver Regeneration and Weight Gain: a Conspicuous Pathophysiological Triad

Ishtiaq

Khan

Arshad

2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Psychosocial stress alters several physiological parameters resulting in multiple disorders, particularly compromising the immune system thereby provoking various diseases including liver disorders. However, the plausible underlying mechanisms remain elusive. Recent literature provides mechanistic evidences of detrimental effects of psychosocial stress on physiology of different body organs including liver. The data of stress-induced pathophysiological changes in liver functions and obesity were systematically collected from PubMed, ScienceDirect and the Web of Science Databases published in English. Stress and glucocorticoids (GCs) control food intake and energy expenditure through appetite stimulators neuropeptide Y (NYP) and agouti-related protein (AgRP) in hypothalamus. Principle effectors of the activated hypothalamic-pituitary-adrenal (HPA) axis in response to psychosocial stress are proopiomelanocortin (POMC)-derived adrenocorticotropic hormone (ACTH) and GCs. Stress-induced GCs hyper-secretion triggers glucocorticoid receptor (GR)-dependent transcriptional factor, nuclear factor kappa B (NFκB), which interferes TNFα-IL6 and keap1-Nrf2 pathways in liver regeneration and obesity through fine-tuning of TNFα, IL6 and Nrf2 signaling. In this review, it is contrived upon existing evidence to put forward a model whereby exposure to life-stress has a prominent impact over weight gain and can alter the regenerative mode of a damaged liver through Keap1-Nrf2 and TNFa-IL6 pathways.

show abstract

“…The prevention of lifestyle-related diseases is very important to save healthy living [1][2]. Therefore, personal health check and care have attracted significant attention and are increasing using wearable device, ubiquitous device and internet of things (IoT) service [3][4].…”

Section: Introductionmentioning

confidence: 99%

Integrated Design of Low-power Adiabatic Dynamic CMOS Logic using 0.18μm Standard CMOS Model for Circadian Rhythm OLED Illumination System

Cho¹,

Yokoyama²

2017

IJCA

View full text Add to dashboard Cite

show abstract

Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases

Cited by 104 publications

References 144 publications

Epigenetic aging in children from a small‐scale farming society in The Congo Basin: Associations with child growth and family conflict

Epigenetic aging in children from a small‐scale farming society in The Congo Basin: Associations with child growth and family conflict

Psychosocial-Stress, Liver Regeneration and Weight Gain: a Conspicuous Pathophysiological Triad

Integrated Design of Low-power Adiabatic Dynamic CMOS Logic using 0.18μm Standard CMOS Model for Circadian Rhythm OLED Illumination System

Contact Info

Product

Resources

About