Life Course Perspectives on the Epidemiology of Depression

Colman, Ian; Ataullahjan, Anushka

doi:10.1177/070674371005501002

Cited by 123 publications

(95 citation statements)

References 170 publications

(245 reference statements)

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“…These findings build upon a previous study that noted an association between lower levels of self-rated health and future depression in a population-based cohort 32 and a study of older adults in which self-rated health was found to identify those most at risk of depression.…”

Section: Discussionmentioning

confidence: 77%

“…Compared with those rating their health as good to excellent, those rating their health as poor to fair had a twofold greater risk of MDS up to 5 years later. The association between self-rated health and future depressive status remained strong even after adjusting for age, sex, multimorbidity, and baseline depression status or severity.These findings build upon a previous study that noted an association between lower levels of self-rated health and future depression in a population-based cohort 32 and a study of older adults in which self-rated health was found to identify those most at risk of depression.33 Participants rating their health as good to excellent had a risk of future depression similar to that of the general primary care patient population, 4,48 Note: Flowchart of participants who were active in the cohort at each year after they withdrew or died, and the number of active participants that returned the survey questionnaire. a N = 761.…”

mentioning

confidence: 74%

“…Two studies suggest that self-rated health may be an important predictor of poor depression outcome. 32,33 An association between worse self-rated health and poor depression outcome 6 years later was noted in a study of 585 people with major depression drawn from a population-based longitudinal health survey.…”

Section: Introductionmentioning

confidence: 99%

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Self-Rated Health and Long-Term Prognosis of Depression

Ambresin

Chondros

Dowrick

et al. 2014

The Annals of Family Medicine

125

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PURPOSE Indicators of prognosis should be considered to fully inform clinical decision making in the treatment of depression. This study examines whether self-rated health predicts long-term depression outcomes in primary care. METHODSOur analysis was based on the first 5 years of a prospective 10-year cohort study underway since January 2005 conducted in 30 randomly selected Australian primary care practices. Participants were 789 adult patients with a history of depressive symptoms. Main outcome measures include risks, risk differences, and risk ratios of major depressive syndrome (MDS) on the Patient Health Questionnaire.RESULTS Retention rates during the 5 years were 660 (84%), 586 (74%), 560 (71%), 533 (68%), and 517 (66%). At baseline, MDS was present in 27% (95% CI, 23%-30%). Cross-sectional analysis of baseline data showed participants reporting poor or fair self-rated health had greater odds of chronic illness, MDS, and lower socioeconomic status than those reporting good to excellent self-rated health. For participants rating their health as poor to fair compared with those rating it good to excellent, risk ratios of MDS were 2.10 (95% CI, 1.60-2.76), 2.38 (95% CI, 1.77-3.20), 2.22 (95% CI, 1.70-2.89), 1.73 (95% CI, 1.30-2.28), and 2.15 (95% CI, 1.59-2.90) at 1, 2, 3, 4, and 5 years, after accounting for missing data using multiple imputation. After adjusting for age, sex, multimorbidity, and depression status and severity, self-rated health remained a predictor of MDS up to 5 years.CONCLUSIONS Self-rated health offers family physicians an efficient and simple way to identify patients at risk of poor long-term depression outcomes and to inform therapeutic decision making. INTRODUCTIOND epression is the largest contributor to the burden of disease in high-income countries, and further increases are expected.1,2 Of those who seek professional help for depression, 80% turn to a primary care physician. 3 The high prevalence of depressive symptoms in primary care patients highlights the crucial role of primary care in the detection and treatment of depression. 4,5 In clinical practice understanding the prognosis for an individual is central to fully inform treatment decisions, 6 yet prognosis has received limited attention compared with therapeutic and etiological research. 6,7 Validated prognostic indices provide estimates of the probability of an outcome for those with a particular condition 7 and offer improved accuracy in prognostic assumptions that influence clinical decisions. The accuracy of family physicians in predicting the course of depression is described as fair, 9 although as in other conditions it has been studied relatively little. Self-rated health may be a candidate for a simple and transportable prognostic index. It provides a singlequestion assessment of one's subjective health, encompassing physical functioning, as well as psychosocial aspects of health.25,26 Self-rated health has been used as a reliable, quick assessment for population health monitoring. [27][28][29] Two lar...

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Section: Discussionmentioning

confidence: 77%

mentioning

confidence: 74%

See 1 more Smart Citation

Self-Rated Health and Long-Term Prognosis of Depression

Ambresin

Chondros

Dowrick

et al. 2014

The Annals of Family Medicine

125

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“…19 Multiple studies suggest that exposure to psychosocial risk factors and adversities, both chronic and acute, throughout the life course may increase individuals' chances for developing depression. [20][21][22] However, existing literature suggests that mental health disorders have a fairly strong genetic component [23][24][25] , and individuals with a high genetic risk for depression are likely to develop episodes of the disorder even without experiencing notable environmental stress. 26 Longitudinal studies have identified some early risk factors as being predictive of later depression in general populations, including low socioeconomic status, family history of depression, family conflict, early depressive symptoms, conduct problems, substance use, delinquent behavior, and negative life events.…”

Section: Introductionmentioning

confidence: 99%

Early Life Predictors of Adult Depression in a Community Cohort of Urban African Americans

et al. 2012

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Depression among African Americans residing in urban communities is a complex, major public health problem; however, few studies identify early life risk factors for depression among urban African American men and women. To better inform prevention programming, this study uses data from the Woodlawn Study, a welldefined community cohort of urban African Americans followed from age 6 to 42 years, to determine depression prevalence through midlife and identify childhood and adolescent risk factors for adult depression separately by gender. Results indicate that lifetime depression rates do not differ significantly by gender (16.2 % of men, 18.8 % of women) in contrast to findings of a higher prevalence for women in national studies. Furthermore, rates of depression in this urban African American population are higher than those found in national samples of African Americans and more comparable to the higher rates found nationally among Whites. Regarding early predictors, for both men and women, family conflict in adolescence is a risk factor for adult depression in multivariate regression models. For women, vulnerability to depression has roots in early life, specifically, low maternal aspirations for school attainment. Females displaying more aggressive and delinquent behavior and those growing up in a female-headed household and a household with low maternal education have elevated rates of depression. Males growing up in persistent poverty, those engaging in greater delinquent behavior, and those with low parental supervision in adolescence also have elevated rates of depression. Effective prevention programming for urban African Americans must consider both individual characteristics and the family dynamic.

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“…The study showed that 2-bromo-1-(thietan-3-yl) imidazole-4,5-dicarboxylic acid salts and diylidenehydrazidеs may have an antidepressant effect. Depression refers to socially significant diseases, which is due to their high prevalence [6]. The study of the antidepressant activity of known drugs [7] and the search for new sources of antidepressant drugs are continuing [8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antidepressant Activity of 2-Bromo-1-(Thietan-3-Yl) Imidazole-4, 5-Dicarboxylic Acid Derivatives

Халиуллин

Никитина

Валиева

et al. 2017

Int J Pharm Pharm Sci

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Objective: Synthesis of the salts and diylidenehydrazidеs of 2-bromo-1-(thietan-3-yl) imidazole-4,5-dicarboxylic acid to evaluate the antidepressant activities. Methods:The structures of the synthesised compounds were confirmed by elemental analysis and 1Results: All synthesised compounds showed antidepressant activity after single intraperitoneal injection to male mice at doses equimolar to 10 mg/kg of imipramine. One of the compounds, 2-bromo-1-(thietan-3-yl) imidazole-4,5-dicarboxylic acid di [(4-hydroxy-3-methoxyphenyl) methylidenehydrazide], reduced the anxiety and decreased the locomotor activity at statistically significant levels. Other compounds did not have sedative and/or stimulating effects.Н NMR spectral data. The melting points of the compounds were determined on a Stuart SMP30 apparatus. The X-ray diffraction data for compound IIc were obtained at room temperature on a Xcalibur Gemini Еos. The antidepressant activity was investigated in the tail suspension and forced swimming tests. The locomotor activity and anxiety were studied in the open field test. Conclusion:Among the synthesised 2-bromo-1-(thietan-3-yl) imidazole-4,5-dicarboxylic acid derivatives, compounds with marked antidepressant activity were identified. An obvious advantage of these products is low toxicity.

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Life Course Perspectives on the Epidemiology of Depression

Cited by 123 publications

References 170 publications

Self-Rated Health and Long-Term Prognosis of Depression

Self-Rated Health and Long-Term Prognosis of Depression

Early Life Predictors of Adult Depression in a Community Cohort of Urban African Americans

Synthesis and Antidepressant Activity of 2-Bromo-1-(Thietan-3-Yl) Imidazole-4, 5-Dicarboxylic Acid Derivatives

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