Life Course Influences on Insulin Resistance

Lawlor, Debbie A.; Smith, George Davey; Ebrahim, Shah

doi:10.2337/diacare.26.1.97

Cited by 74 publications

(61 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7,[35][36][37][38][39] However, when the estimates obtained for each measure of obesity were controlled for potential confounders and for the other obesity measure, the results relative to SBP are less consistent, and in some cases the association disappears. 21,36,37 In our study, as well, the association between body mass index and increased SBP in women and between waist-to-hip ratio and increased SBP in men disappeared after adjusting for the other measures of obesity. Only the association between waist circumference and SBP in women remained after adjusting for all the variables.…”

Section: Pulse Systolic and Diastolic Blood Pressure In Older Peoplesupporting

confidence: 60%

“…Most, 20 but not all, 21,22 studies have observed that impaired foetal development -reflected by low birth weight or other indicators -is associated with increased blood pressure in adulthood. As prenatal growth influences height reached in adulthood, 23 the failure to adjust for some indicator of foetal development could have overestimated the magnitude of the association between height and SBP and underestimated the magnitude of the association between height and DBP.…”

Section: Data Limitationsmentioning

confidence: 99%

See 1 more Smart Citation

Influence of childhood socioeconomic circumstances, height, and obesity on pulse pressure and systolic and diastolic blood pressure in older people

et al. 2005

View full text Add to dashboard Cite

This study assesses the association of childhood socioeconomic circumstances, height, and obesity with components of blood pressure. We selected 4009 people representative of the Spanish population aged 60 years and older, and estimated systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP) according to childhood social class, height, and obesity. No association was found between childhood social class and blood pressure. SBP showed an inverse gradient and DBP a direct gradient with height, although an independent association between height and DBP was found only in women. Stature was independently associated with increased DBP in women with central obesity, but there was no association between height and DBP in women without central obesity. Short stature was independently associated with increased PP. Body mass index and waist-to-hip ratio were independently associated with increased DBP in women, and waist-to-hip ratio was independently associated with increased PP in men, while waist circumference was independently associated with increased DBP and increased PP in women. These results do not support the assumed effect of socioeconomic circumstances in early life on blood pressure, which may depend on the context and/or study population. The relations observed between height and blood pressure support the hypothesis that PP could be a mediator of the association between short stature and increased cardiovascular risk. The relationship between obesity measures and components of blood pressure reinforces the recommendation to reduce body weight in order to reduce blood pressure.

show abstract

Section: Pulse Systolic and Diastolic Blood Pressure In Older Peoplesupporting

confidence: 60%

Section: Data Limitationsmentioning

confidence: 99%

Influence of childhood socioeconomic circumstances, height, and obesity on pulse pressure and systolic and diastolic blood pressure in older people

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Assessment of lipids and C-reactive protein was done using standard procedures. 21,22 Full ethics committee approval for the study was obtained from Local Ethics Committees in each of the 23 participating towns and informed consent to review their general practice medical records was obtained from each participant included in the study.…”

Section: Methodsmentioning

confidence: 99%

A comparison of associations of alanine aminotransferase and gamma-glutamyltransferase with fasting glucose, fasting insulin, and glycated hemoglobin in women with and without diabetes

et al. 2007

Self Cite

View full text Add to dashboard Cite

“…This is suggested by several epidemiological studies describing specific patterns of early growth, such as low weight gain in infancy and rapid gain in BMI during childhood, that aggravate the association between low birth weight and metabolic characteristics and health in later life. 2,4,[38][39][40][41] In a recent study on associations between birth measures and glucose intolerance, we showed that subjects born light or thin benefited specifically from regular exercise. 42 These findings constitute a rationale for future intervention studies, aiming at increasing muscle mass in relation to fat mass, to prevent type 2 diabetes, cardiovascular disease and related traits in individuals at increased risk of these disorders because of their low birth weight.…”

Section: Public Health Implicationsmentioning

confidence: 99%

Birth size, adult body composition and muscle strength in later life

Ylihärsilä¹,

Kajantie²,

et al. 2007

View full text Add to dashboard Cite

Objective: Low birth weight has been linked to lower lean body mass and abdominal obesity later in life, whereas high birth weight has been suggested to predict later obesity as indicated by high body mass index (BMI). We examined how birth weight was related to adult body size, body composition and grip strength. Design/subjects: Cross-sectional study on 928 men and 1075 women born in [1934][1935][1936][1937][1938][1939][1940][1941][1942][1943][1944], with measurements at birth recorded. Measurements: Height, weight, waist and hip circumference and isometric grip strength were measured. Lean and fat body mass were estimated by bioelectrical impedance with an eight-polar tactile electrode system. Results: A 1 kg increase in birth weight corresponded in men to a 4.1 kg (95% CI: 3.1, 5.1) and in women to a 2.9 kg (2.1, 3.6) increase in adult lean mass. This association remained significant after adjustment for age, adult body size, physical activity, smoking status, social class and maternal size. Grip strength was positively related to birth weight through its association with lean mass. The positive association of birth weight with adult BMI was explained by its association with lean mass. Low birth weight was related to higher body fat percentage only after adjustment for adult BMI. Abdominal obesity was not predicted by low birth weight. Conclusions: Low birth weight is associated with lower lean mass in adult life and thus contributes to the risk of relative sarcopenia and the related functional inability at the other end of the lifespan. At a given level of adult BMI, low birth weight predicts higher body fat percentage.

show abstract

Life Course Influences on Insulin Resistance

Cited by 74 publications

References 39 publications

Influence of childhood socioeconomic circumstances, height, and obesity on pulse pressure and systolic and diastolic blood pressure in older people

Influence of childhood socioeconomic circumstances, height, and obesity on pulse pressure and systolic and diastolic blood pressure in older people

A comparison of associations of alanine aminotransferase and gamma-glutamyltransferase with fasting glucose, fasting insulin, and glycated hemoglobin in women with and without diabetes

Birth size, adult body composition and muscle strength in later life

Contact Info

Product

Resources

About