Life after breast cancer: ‘Being’ a young African American survivor

Nolan, Timiya S.; Ivankova, Nataliya V.; Carson, Tiffany L.; Spaulding, Amelia M.; Dunovan, Shanon; Davies, Susan L.; Enah, Comfort; Meneses, Karen

doi:10.1080/13557858.2019.1682524

Cited by 9 publications

(28 citation statements)

References 56 publications

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“…Spirituality in cancer survivorship has been studied with regards to coping and quality of life, [60][61][62]…”

Section: Discussionmentioning

confidence: 99%

“…African American women in particular expressed how spirituality helped with acceptance of body changes and finding meaning in their experience. Spirituality in cancer survivorship has been studied with regards to coping and quality of life, 60–62 however, more research is needed to understand how spirituality may be leveraged in interventions for women's sexual wellbeing after cancer.…”

Section: Discussionmentioning

confidence: 99%

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Sexual health and intimacy after cancer treatment in women of color: A systematic review

et al. 2022

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Objective: Cancer diagnosis and treatment can significantly affect women's sexual health and intimacy, leading to diminished quality of life in survivorship. The perspectives and experiences of women of color (WOC) with cancer are critical to inform comprehensive, inclusive sexual wellbeing care in survivorship. The purpose of this systematic review is to summarize contemporary literature describing sexual wellbeing experiences of WOC treated for cancer. Methods: A comprehensive search of CINAHL, PubMed, Embase and PsycInfo and Scopus identified studies that addressed sex and intimacy of U.S. WOC treated for cancer published in the last 15 years. The authors identified emergent themes from the literature through thematic content analysis.Results: Eighteen studies (10 qualitative, 8 quantitative) met the inclusion criteria, all with breast or gynecologic cancer samples. Studies include African American (13), Asian American (3), and Latina (10) women, as well as Non-Hispanic Whites and 'other' race/ethnicity women. Overarching themes identified were: 1) impacts of treatment on sexual health and body image, 2) process of accepting and overcoming, 3) value of an engaged and supportive partner, and 4) current clinical practice and barriers to sexual health care. Conclusions: WOC experience changes in sex and intimacy after cancer treatment, and experiences of sexual function, sexual communication, and sexual healthcare are often shaped by sociocultural experiences. An understanding of WOC's sexual health and intimacy after cancer treatment can inform inclusive, culturally responsive sexual health interventions.

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“…Spirituality in cancer survivorship has been studied with regards to coping and quality of life, [60][61][62]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sexual health and intimacy after cancer treatment in women of color: A systematic review

et al. 2022

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“…Seven papers focused on metastatic BC [39][40][41][42][43][44][45]. Five focused on African American survivors [46][47][48][49][50], eleven on 'younger' survivors (e.g. under 50 years) [41,43,49,[51][52][53][54][55][56][57][58], nine on return to work [59][60][61][62][63][64][65][66][67], two on cognitive difficulties [68,69], four on lymphoedema [65,[70][71][72], four on cancer-related fatigue [73][74][75][76], five on sexual and/or reproductive health [51,58,[77][78][79], and four on healthy lifestyle factors (i.e.…”

Section: Study Characteristicsmentioning

confidence: 99%

Psychosocial experiences of breast cancer survivors: a meta-review

Butow

Giunta

et al. 2023

J Cancer Surviv

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Purpose Advances in breast cancer care have led to a high rate of survivorship. This meta-review (systematic review of reviews) assesses and synthesises the voluminous qualitative survivorship evidence-base, providing a comprehensive overview of the main themes regarding breast cancer survivorship experiences, and areas requiring further investigation. Methods Sixteen breast cancer reviews identified by a previous mixed cancer survivorship meta-review were included, with additional reviews published between 1998 and 2020, and primary papers published after the last comprehensive systematic review between 2018 and 2020, identified via database searches (MEDLINE, Embase, CINAHL, PsycINFO). Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Systematic Reviews and the CASP (Critical Appraisal Skills Programme Qualitative) checklist for primary studies. A meta-ethnographic approach was used to synthesise data. Results Of 1673 review titles retrieved, 9 additional reviews were eligible (25 reviews included in total). Additionally, 76 individual papers were eligible from 2273 unique papers. Reviews and studies commonly focused on specific survivorship groups (including those from ethnic minorities, younger/older, or with metastatic/advanced disease), and topics (including return to work). Eight themes emerged: (1) Ongoing impact and search for normalcy, (2) Uncertainty, (3) Identity: Loss and change, (4) Isolation and being misunderstood, (5) Posttraumatic growth, (6) Return to work, (7) Quality of care, and (8) Support needs and coping strategies. Conclusions Breast cancer survivors continue to face challenges and require interventions to address these. Implications for Cancer Survivors. Breast cancer survivors may need to prepare for ongoing psychosocial challenges in survivorship and proactively seek support to overcome these.

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“…Recent studies have shown up to a twofold higher incidence of triple-negative breast cancer (TNBC) among African American women as compared to White women [ 2 – 4 ]. Moreover, African Americans die from breast cancer at up to 40% higher rate than White and Hispanic women [ 5 – 7 ]. The American College of Radiology (ACR) has assigned a special status for African American women at higher-than-average risk for breast cancer [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…up to 40% higher rate than White and Hispanic women [5][6][7]. The American College of Radiology (ACR) has assigned a special status for African American women at higher-than-average risk for breast cancer [8].…”

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confidence: 99%

High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients

et al. 2020

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Background: African American women experience a twofold higher incidence of triple-negative breast cancer (TNBC) and are 40% more likely to die from breast cancer than women of other ethnicities. However, the molecular bases for the survival disparity in breast cancer remain unclear, and no race-specific therapeutic targets have been proposed. To address this knowledge gap, we performed a systematic analysis of the relationship between gene mRNA expression and clinical outcomes determined for The Cancer Genome Atlas (TCGA) breast cancer patient cohort. Methods: The systematic differential analysis of mRNA expression integrated with the analysis of clinical outcomes was performed for 1055 samples from the breast invasive carcinoma TCGA PanCancer cohorts. A deep learning fullyconvolutional model was used to determine the association between gene expression and tumor features based on breast cancer patient histopathological images. Results: We found that more than 30% of all protein-coding genes are differentially expressed in White and African American breast cancer patients. We have determined a set of 32 genes whose overexpression in African American patients strongly correlates with decreased survival of African American but not White breast cancer patients. Among those genes, the overexpression of mitogen-activated protein kinase kinase 3 (MKK3) has one of the most dramatic and race-specific negative impacts on the survival of African American patients, specifically with triple-negative breast cancer. We found that MKK3 can promote the TNBC tumorigenesis in African American patients in part by activating of the epithelial-to-mesenchymal transition induced by master regulator MYC. Conclusions: The poor clinical outcomes in African American women with breast cancer can be associated with the abnormal elevation of individual gene expression. Such genes, including those identified and prioritized in this study, could represent new targets for therapeutic intervention. A strong correlation between MKK3 overexpression, activation of its binding partner and major oncogene MYC, and worsened clinical outcomes suggests the MKK3-MYC protein-protein interaction as a new promising target to reduce racial disparity in breast cancer survival.

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Life after breast cancer: ‘Being’ a young African American survivor

Cited by 9 publications

References 56 publications

Sexual health and intimacy after cancer treatment in women of color: A systematic review

Sexual health and intimacy after cancer treatment in women of color: A systematic review

Psychosocial experiences of breast cancer survivors: a meta-review

High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients

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