Lidocaine Patch for Pain of Erythromelalgia

Comparative Efficacy and Tolerability of Treatments for Erythromelalgia: A Systematic Review

“…Similarly, in a study involving 34 patients with EM who were treated at a specialized facility, most of those who applied lidocaine 5% patches reported reduced pain. This was in contrast to a group of 10 patients who did not experience any relief when using lidocaine gel [ 33 ]. Michelerio et al [ 22 ] emphasized the differing levels of effectiveness among various treatments, identifying antihistamines, venlafaxine, and mexiletine as the most promising options.…”

Topical treatments for erythromelalgia

“…8 This observation is supported by a follow-up case series study, which showed that the lidocaine patch improved symptoms in 18 out of 34 erythromelalgia patients. 6 Lidocaine patches can also be effectively utilized in pediatric patients. In a review of 32 pediatric erythromelalgia cases, lidocaine was the most commonly prescribed treatment (44%).…”

Severe Erythromelalgia Pain Attack in a Young Lebanese Woman Leading to Hospitalization: A Case Report and Literature Review

“…Topical agents may be used to avoid systemic adverse effects. Preparations containing amitriptyline-ketamine, lidocaine, midodrine (α1-agonist), NSAIDs, and gabapentin have been described, with variable success in symptom control [ 32 , 33 ]. Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), derived from chili peppers and commonly used for diabetic and postherpetic neuropathy, has shown success in alleviating pain in erythromelalgia in several case reports [ 34 , 35 ].…”