Lidocaine Patch for Pain of Erythromelalgia

Pediatric erythromelalgia: A?retrospective review of 32 cases evaluated at Mayo Clinic over a 37-year period

“…One of these cases was previously published. 19 Five reported marked improvement, one reported no improvement, and 8 were lost to follow-up. Eight patients (25%) were treated with gabapentin; 3 reported no change in symptoms and the other 5 were lost to follow-up.…”

“…3,22 We noted that lidocaine patches were helpful for pain relief in many patients, as has been reported in adult patients at our institution. 23 Other agents and treatment methods described in case reports of erythromelalgiaesuch as intravenous lidocaine and oral mexiletine in combination, sodium nitroprusside, recombinant growth hormone, regional anesthesia blockade, and thalamic stimulation 20,24-29 ewere not used in our patients.…”

Combination Gel of 1% Amitriptyline and 0.5% Ketamine to Treat Refractory Erythromelalgia Pain

“…Consequently, we attempted to treat other patients with a topical local anesthetic and had varying success. 8 However, every treatment at our disposal seemed to fail in some patients. Therefore, we decided to use a combination cream or gel of amitriptyline and ketamine in pluronic lecithin organogel.…”

Managing late onset primary erythromelalgia with oral pregabalin

“…Symptomatic responses have been reported to aspirin therapy (for erythromelalgia related to thrombocytosis), sodium nitroprusside, propranolol, high dose magnesium, lignocaine patch, amitriptyline and gabapentin. [4][5][6][7][8] The involvement of secondary causes must be ruled out in cases with confirmed diagnosis. Erythromelalgia can be associated with SLE, Raynaud's disease, pernicious anemia, thrombotic thrombocytopenic purpura, infectious mononucleosis, metabolic, endocrine, and vascular origin and diabetic neuropathy.…”