Archives of Otolaryngology - Head and Neck Surgery
 1982
DOI: 10.1001/archotol.1982.00790560009003
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Lidocaine in the Treatment of Tinnitus Aurium: A Double-blind Study

Jeffrey Israel1,
J. S. Connelly2,
S. T. McTigue3
et al.
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Cited by 64 publications

(34 citation statements)
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“…The percentage of patients who improved was similar to the earlier studies already reported. Similarly, in a placebo-controlled, double-blind crossover study, Israel et al 13 reported tinnitus improvement in 19of 26 patients. Interestingly, two patients in the series believed their tinnitus was worse after the injection and all patients reported temporary side effects.…”
Section: Resultsmentioning
confidence: 88%
“…Israel et a1. 13 also found the integrity of their double-blind crossover protocol potentially compromised by similar adverse reactions. Other investigators have not reported similar side effects following injection of lidocaine.4.9•12 This difference in results is difficult to explain, given the similarity between the experimental protocols.…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The percentage of patients who improved was similar to the earlier studies already reported. Similarly, in a placebo-controlled, double-blind crossover study, Israel et al 13 reported tinnitus improvement in 19of 26 patients. Interestingly, two patients in the series believed their tinnitus was worse after the injection and all patients reported temporary side effects.…”
Section: Resultsmentioning
confidence: 88%
“…Israel et a1. 13 also found the integrity of their double-blind crossover protocol potentially compromised by similar adverse reactions. Other investigators have not reported similar side effects following injection of lidocaine.4.9•12 This difference in results is difficult to explain, given the similarity between the experimental protocols.…”
Section: Discussionmentioning
confidence: 97%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Similar concern was expressed by Israel et al" (1982), who believed that their double-blind protocol had been compromised by similar adverse effects. For these reasons we elected to investigate the contribution of a placebo effect in the management of tinnitus.…”
mentioning
confidence: 84%
“…In addition to being concerned about the bias inher-ent in single-blind protocols, we were concerned that the high incidence of side effects we observed could have biased our own results. Similar concern was expressed by Israel et al" (1982), who believed that their double-blind protocol had been compromised by similar adverse effects. For these reasons we elected to investigate the contribution of a placebo effect in the management of tinnitus.…”
mentioning
confidence: 84%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Historically, perhaps the most effective treatment for tinnitus was intravenous lidocaine which transiently decreased tinnitus in 70% of patients. 52 However, due to the limited duration of symptom relief and potentially fatal side effect profile, this treatment was never adopted. 53 Various treatments including cognitive behavioral therapy, sound maskers, hearing aids, medications, hyperbaric oxygen, acupuncture, and neuromodulation have failed to show definitive evidence of reducing tinnitus loudness.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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