1999
DOI: 10.1001/archderm.135.12.1447
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Lidocaine and Mexiletine Therapy for Erythromelalgia

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Cited by 50 publications
(31 citation statements)
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“…The local anesthetics lidocaine and mexiletine can be efficient for treatment of pain associated with IEM [59,61,73,90]. In a recent study, mexiletine induced a significant pain relief in a child with the IEM mutation V872G which persisted even after the treatment was discontinued.…”
Section: Mutation-selective Therapy For Iem and Pepd?mentioning
confidence: 99%
“…The local anesthetics lidocaine and mexiletine can be efficient for treatment of pain associated with IEM [59,61,73,90]. In a recent study, mexiletine induced a significant pain relief in a child with the IEM mutation V872G which persisted even after the treatment was discontinued.…”
Section: Mutation-selective Therapy For Iem and Pepd?mentioning
confidence: 99%
“…This hypothesis may be compatible with data from occasional cases indicating that treatment with mexiletine hydrochloride, a sodium channel-blocking agent, was favorable in reducing burning pain and red swelling to bearable proportions. 11 The specific physiological effect of the S241T mutation, however, needs to be determined by functional studies of mutated Nav1.7. 6,12 In summary, we report a novel mutation in the SCN9A gene associated with autosomal dominant primary erythermalgia.…”
Section: Commentmentioning
confidence: 99%
“…These medications appear especially useful for patients with allodynia [37,38]. Other proposed uses of either mexiletine or IV lidocaine include the treatment of central pain syndrome [39], fibromyalgia [40], erythromelalgia [41], postoperative pain [42], and positive symptoms in multiple sclerosis [43]. Mexiletine and phenytoin are commonly used for symptomatic myotonia [44].…”
Section: Lidocaine and Mexiletine In The Treatment Of Painmentioning
confidence: 99%