Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis

Xuan, Yue; Li, Tao; Xiao, Er-Long; Zhao, Hong; Li, Yongqian; Fu, Shengjun; Gan, Lu; Wang, Zhenhua; Zheng, Qi; Wang, Zhiping

doi:10.1016/j.fct.2013.12.030

Cited by 48 publications

(46 citation statements)

References 34 publications

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“…Licochalcone-A, a chalconoid and a type of natural phenol, has been isolated from the root of the licorice plant and has exhibited various pharmacological effects, including antimalarial, anticancer, antibacterial and antiviral properties (7). Furthermore, treatment with licochalcone-A induced apoptosis in various cancer cell types, including oral (36), bladder (37,38), lung (39), gastric (40) and prostate cancer cells (41). In addition, Lico-E, a retrochalone, with various pharmacological effects, including antiparasitic, antibacterial, antioxidative and superoxide-scavenging properties, has been isolated from the root of licorice (24).…”

Section: Discussionmentioning

confidence: 99%

Licochalcone-E induces caspase-dependent death of human pharyngeal squamous carcinoma cells through the extrinsic and intrinsic apoptotic signaling pathways

Cho

Kang

et al. 2017

Oncology Letters

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Abstract. The aim of the present study was to investigate licochalcone-E (Lico-E)-induced apoptosis and the associated apoptotic signaling pathway in FaDu cells, a human pharyngeal squamous carcinoma cell line. Treatment with Lico-E exhibited significant cytotoxicity on FaDu cells in a concentration-dependent manner. The IC 50 value of Lico-E in FaDu cells was ~50 µM. Treatment with Lico-E increased the number of dead FaDu cells. Furthermore, chromatin condensation, which is associated with apoptotic cell death, was observed in FaDu cells treated with Lico-E for 24 h. By contrast, Lico-E did not produce cytotoxicity or increase the number of dead cells when applied to human normal oral keratinocytes (hNOKs). Furthermore, chromatin condensation was not observed in hNOKs treated with Lico-E. Treatment with Lico-E increased the expression of Fas ligand and the cleaved form of caspase-8 in FaDu cells. Furthermore, treatment with Lico-E increased the expression of pro-apoptotic factors, including apoptosis regulator BAX, Bcl-2-associated agonist of cell death, apoptotic protease-activating factor 1, caspase-9 and tumor suppressor p53, while decreasing the expression of anti-apoptotic factors, including apoptosis regulator Bcl-2 and Bcl-2-like protein 1 in FaDu cells. The expression of cleaved caspases-3 and poly (ADP-ribose) polymerase was significantly upregulated following treatment with Lico-E in FaDu cells, while Lico-E-induced apoptotic FaDu cell death was partially suppressed by treatment with Z-VAD-FMK, a pan caspase inhibitor. Therefore, Lico-E-induced oral cancer (OC) cell-specific apoptosis is mediated by the death receptor-dependent extrinsic and mitochondrial-dependent intrinsic apoptotic signaling pathways. In conclusion, these data suggested that Lico-E exhibits potential chemopreventive effects and warrants further developed as a chemotherapeutic agent against OC.

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Section: Discussionmentioning

confidence: 99%

Licochalcone-E induces caspase-dependent death of human pharyngeal squamous carcinoma cells through the extrinsic and intrinsic apoptotic signaling pathways

Cho

Kang

et al. 2017

Oncology Letters

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“…Licochalcone B led to S-phase arrest, decreased the expression of cyclin A, CDK1, CDK2 mRNA, Bcl-2, survivin, and cell division cycle 25 (Cdc25A and Cdc25B) proteins, induced downregulation of antiapoptotic proteins (Bid, Bcl-xl, and Mcl-1), and also caused the loss of [43,44]. However, it enhanced Bax expression, activated caspase-3, and cleaved poly ADP-ribose polymerase (PARP) protein [44]. In addition, it attenuated migration, adhesion, and invasion of cancer cells accompanied with the downregulated protein expression of MMP-9 and nuclear translocation of nuclear factor-κB (NF-κB) [115].…”

Section: Anticancer Activitymentioning

confidence: 99%

Natural Chalcones in Chinese Materia Medica: Licorice

Wang

Liang

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Licorice is an important Chinese materia medica frequently used in clinical practice, which contains more than 20 triterpenoids and 300 flavonoids. Chalcone, one of the major classes of flavonoid, has a variety of biological activities and is widely distributed in nature. To date, about 42 chalcones have been isolated and identified from licorice. These chalcones play a pivotal role when licorice exerts its pharmacological effects. According to the research reports, these compounds have a wide range of biological activities, containing anticancer, anti-inflammatory, antimicrobial, antioxidative, antiviral, antidiabetic, antidepressive, hepatoprotective activities, and so on. This review aims to summarize structures and biological activities of chalcones from licorice. We hope that this work can provide a theoretical basis for the further studies of chalcones from licorice.

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“…DDP is a novel licochalcone B derivative which has 3,4-dihydroxy-2-methoxy substituent and a resorcinol type ring A. Although licochalcone B has several pharmacological attributes including anti-cancer [15], anti-oxidant, and anti-inflammatory [16,17] activity, no report on DPP's anti-inflammatory activities or the molecular mechanisms involved has been published.…”

Section: Introductionmentioning

confidence: 98%

(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one, a novel licochalcone B derivative compound, suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice

Park

Jun

Kim

2014

Chemico-Biological Interactions

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Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis

Cited by 48 publications

References 34 publications

Licochalcone-E induces caspase-dependent death of human pharyngeal squamous carcinoma cells through the extrinsic and intrinsic apoptotic signaling pathways

Licochalcone-E induces caspase-dependent death of human pharyngeal squamous carcinoma cells through the extrinsic and intrinsic apoptotic signaling pathways

Natural Chalcones in Chinese Materia Medica: Licorice

(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one, a novel licochalcone B derivative compound, suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice

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