1951
DOI: 10.1001/archderm.1951.01570090087011
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Lichen Simplex Chronicus and Its Variants

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Cited by 42 publications
(6 citation statements)
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“…The histologic features of hyperkeratosis, hypergranulosis, and adnexal and interadnexal epithelial hyperplasia may then reflect an actinically‐induced abnormality in a clone of keratinocytes or may be secondary to chronic rubbing. In agreement with Bilano and Little, 4 we believe that these features may be caused by rubbing, as they bear a strong resemblance to the histology of lichen simplex chroni‐cus 7,8 . These investigators have previously noted that hypertrophic AKs exhibit a predilection for the dorsal surface of the hands and forearms, 4 and that there may be something about this location that favors this morphology in premalignant and malignant keratoses.…”
Section: Discussionsupporting
confidence: 85%
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“…The histologic features of hyperkeratosis, hypergranulosis, and adnexal and interadnexal epithelial hyperplasia may then reflect an actinically‐induced abnormality in a clone of keratinocytes or may be secondary to chronic rubbing. In agreement with Bilano and Little, 4 we believe that these features may be caused by rubbing, as they bear a strong resemblance to the histology of lichen simplex chroni‐cus 7,8 . These investigators have previously noted that hypertrophic AKs exhibit a predilection for the dorsal surface of the hands and forearms, 4 and that there may be something about this location that favors this morphology in premalignant and malignant keratoses.…”
Section: Discussionsupporting
confidence: 85%
“…Most AKs exhibit significant dysplasia and cytologic atypia and are readily identified by published criteria 1–3 . Most lichen simplex chronicus in published series occurs on the neck, scalp, and legs; there is no particular association with the backs of the hands or with chronically sun‐damaged skin 7,8 …”
Section: Discussionmentioning
confidence: 99%
“…circumscribed neurodermatitis) and PN basically represent the same process clinically, showing lichenified (thickened) skin because of chronic rubbing or irritation. [4][5][6][7] Clinically, LSC presents as a scaly, erythematous plaque with a predilection for the nape of the neck, the ulnar aspect of the forearms, the wrists, the pretibial areas, the dorsa of the feet, and the perianal and genital region, whereas PN is usually characterized by numerous persistent, firm, pink, intensely pruritic nodules predominantly involving the extensor aspect of the limbs. 8,9 In our series, new vessel formation can be seen accompanied by a mild inflammatory cell infiltrate.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, if there was undoubted evidence of osteochondritis associated with periostitis, and if this showed progression during the first 6 weeks of life, the findings might be accepted as diagnostic of syphilis. Shaffer and Courville (1951) x rayed, during the first week of life, the long bones of nearly all of their series of a hundred babies found to have positive serological tests of the cord blood. Five infants born of mothers who received penicillin late in pregnancy showed radiological changes of bones suggestive of syphilis, but in all these cases blood tests became negative without treatment.…”
Section: British Journal Of Venereal Diseasesmentioning
confidence: 99%