1976
DOI: 10.1001/archderm.112.9.1280
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Lichen planus pemphigoides. Immunofluorescence findings

Abstract: A 56-year-old woman developed a vesicular and bullous eruption followed by an efflorescence of lichenoid papules. The clinical and histologic features of this case were consistent with a diagnosis of lichen planus pemphigoides. Direct and indirect immunofluorescence studies demonstrated both in vivo-bound and circulating IgG with specificity for the epidermal basement membrane zone. A common pathogenic immunologic mechanism may exist for both lichen planus and lichen planus pemphigoides, which we believe are c… Show more

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Cited by 23 publications
(12 citation statements)
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“…LP may be an immunological disease as is suggested by the discovery of immune reactants in the lesions (Copeman, 1970), the association with diseases characterized by organ specific antibodies (Tan, 1973a and b), and its occasional merging with lupus erythematosus (Copeman, Schroeter & Kierland, 1970). The destruction ofthe epidermal basal layer in LP accounts for the narrow distinction between bullous LP and LP pemphigoides (Sobel, Miller & Shatin, 1976), and appears to predispose the exceptional individual to develop humoral antibodies against the basement membrane zone so that the staining artefects of an apparently true pemphigoid are provoked (Stingl & Holbar, 1975;Rekaut, 1976).…”
Section: P Wmcopeman Et Almentioning
confidence: 99%
“…LP may be an immunological disease as is suggested by the discovery of immune reactants in the lesions (Copeman, 1970), the association with diseases characterized by organ specific antibodies (Tan, 1973a and b), and its occasional merging with lupus erythematosus (Copeman, Schroeter & Kierland, 1970). The destruction ofthe epidermal basal layer in LP accounts for the narrow distinction between bullous LP and LP pemphigoides (Sobel, Miller & Shatin, 1976), and appears to predispose the exceptional individual to develop humoral antibodies against the basement membrane zone so that the staining artefects of an apparently true pemphigoid are provoked (Stingl & Holbar, 1975;Rekaut, 1976).…”
Section: P Wmcopeman Et Almentioning
confidence: 99%
“…Our patient presented with clinical, histological and immunopathological features characteristic of LPP [1, 2, 3, 4, 5, 6]. The patient exhibited a lichen planus eruption complicated by bullous lesions involving the extremities.…”
Section: Discussionmentioning
confidence: 99%
“…Lichen planus pemphigoides (LPP) is a rare disorder characterized by the presence of lichen planus lesions with vesicles and bullae arising on both involved and uninvolved skin [1, 2, 3]. Light microscopy studies of papular lesions demonstrate features typical of lichen planus, while biopsies obtained from bullous lesions reveal a subepidermal blister usually suggestive of bullous pemphigoid (BP) [1, 2, 3, 4].…”
Section: Introductionmentioning
confidence: 99%
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