Lichen planus-like lesions caused by penicillamine in primary biliary cirrhosis

Seehafer, J. R.

doi:10.1001/archderm.117.3.140

Cited by 34 publications

(19 citation statements)

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“…The observation of co-existing liver disease in 5 patients referred from our hepatology clinic is interesting. Various other reported associations include LP occuring with primary biliary cirrhosis, chronic active hepatitis, primary sclerosing cholangitis, Wilson's disease, hemochromatosis, and alpha-I-antitrypsin deficiency (14,15,31,32).…”

Section: Discussionmentioning

confidence: 99%

“…After the initial studies in the early twentieth century (6,7); subsequent ones have been few and far between (8)(9)(10)(11). Various attempts to associate LP with a variety of systemic maladies, as well as with a number of immune-related diseases (12)(13)(14)(15), have been primarily anecdotal. In view of the paucity of related literature we present in this communication the pattern of LP we observed in patients attending the dermatology out-patient department of our hospital in North India.…”

Section: Introductionmentioning

confidence: 99%

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Lichen Planus: A Clinical and Epidemiological Study

Bhattacharya

Kaur

Kumar

2000

The Journal of Dermatology

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Clinical and epidemiological data from 232 patients with lichen planus is presented. Lichen planus constituted 0.38% of the total dermatology, outpatients diagnosed. The patient ages ranged from 8 to 76 years, most being in the age range from 20 to 49 years. Duration of disease varied from 1 month to 7 years. Both sexes were equally affected. The majority of the patients (47.4%) had classical lesions followed by hypertrophic and actinic lichen planus next in frequency. Itching was the predominant symptom in 79.3%. Limbs were the most frequent initial site of onset (55.6%). Mucosal involvement along with cutaneous lesions were observed in 16.8% and genital involvement in only 5.2%. Nail changes were observed in 15.1% of patients. A history of recurrence of the disease was obtained from 10.3% of patients. Liver disease was found to be associated in 2.2% of patients. No malignant changes were observed in any of the lesions of lichen planus.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lichen Planus: A Clinical and Epidemiological Study

Bhattacharya

Kaur

Kumar

2000

The Journal of Dermatology

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“…In Japan, the rate of HCV infection in OLP is especially high (3). On the other hand, the association between lichen planus and primary biliary cirrhosis (PBC) been reported rarely since Seehafer et al pointed it out in 1981 (4). PBC is a chronic cholestatic liver disease of adults.…”

Section: Introductionmentioning

confidence: 99%

Disappearance of Oral Lichen Planus After Liver Transplantation for Primary Biliary Cirrhosis and Immunosuppressive Therapy in a 63-year-Old Japanese Woman

Nagao

Sata

2014

Hepat Mon

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Introduction:There are few reports concerning association between primary biliary cirrhosis (PBC) and lichen planus. In addition, there is only one report about lichen planus after liver transplantation.Case Presentation:We describe a case of oral lichen planus (OLP) accompanied with PBC that resolved following liver transplantation 14 years later. This patient received immunosuppressive drugs after liver transplantation.Discussion:The disappearance of OLP might be due to immunosuppressive therapy following liver transplantation. Further observations and studies are necessary to clarify the relationship between OLP and PBC.

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“…These include non-steroidal anti-inflammatory drugs [4], allopurinol [5], methyldopa [6], gold salts [7], angiotensin-converting enzyme inhibitors [8], sulphamethoxazole [9]and penicillamine [10]. Drug-induced lichen planus of the oral mucosa may be clinically indistinguishable from idiopathic lichen planus, making differentiation between these two entities difficult.…”

Section: Introductionmentioning

confidence: 99%

Oral Lichenoid Reaction to Imatinib (STI 571, Gleevec)

Lim

Muir²

2002

Dermatology

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Imatinib or STI 571 is a phenylaminopyrimidine derivative and a member of a new class of drugs known as signal transduction inhibitors. These compounds specifically inhibit the proliferation of v-abl- and bcr-abl-expressing cells and have recently been approved as treatment for chronic myeloid leukaemia (CML). Results have been promising, and imatinib may well be the best single agent for the treatment of CML in the near future. Here we report an erosive oral lichenoid eruption confined to the buccal mucosa and dorsum of the tongue which appeared 12 weeks after commencement of imatinib in a 72-year-old woman with CML. The histology was consistent with a lichenoid drug eruption. The lesions resolved upon withdrawal of the drug. To our knowledge, this is the first reported lichenoid reaction to imatinib, and in the setting of CML it must be differentiated from idiopathic lichen planus, paraneoplastic pemphigus and graft-versus-host disease.

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Lichen planus-like lesions caused by penicillamine in primary biliary cirrhosis

Cited by 34 publications

References 0 publications

Lichen Planus: A Clinical and Epidemiological Study

Lichen Planus: A Clinical and Epidemiological Study

Disappearance of Oral Lichen Planus After Liver Transplantation for Primary Biliary Cirrhosis and Immunosuppressive Therapy in a 63-year-Old Japanese Woman

Oral Lichenoid Reaction to Imatinib (STI 571, Gleevec)

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