Lichen planus-like histopathologic characteristics in the cutaneous graft-vs-host reaction. Prognostic significance independent of time course after allogeneic bone marrow transplantation

Horn, T. D.

doi:10.1001/archderm.133.8.961

Cited by 16 publications

(16 citation statements)

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“…8 In addition, a recent study indicates that specific histological features do not consistently separate acute from chronic GVHD as defined by days after BMT. 9 However, the concept of acute cutaneous GVHD appearing after day 100 is not well established.…”

Section: Discussionmentioning

confidence: 99%

“…8 Moreover, a recent study showed that fully evolved histological features of chronic lichenoid GVHD and acute GVHD do not consistently reflect the clinical phase as defined by number of days after BMT. 9 In addition, atypical variants of cutaneous GVHD have been described that do not fit into this diagnostic classification either. Hyperacute or explosive presentations of GVHD may be observed after allogeneic transplantations without or with insufficient GVHD prophylaxis, which are characterized by severe systemic involvement, high mortality, and an erythroderma that evolves from acute to lichenoid within several days of onset with histological features of both acute and chronic lichenoid GVHD.…”

Section: Commentmentioning

confidence: 99%

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Late Appearance of Acute Graft-vs-Host Disease After Suspending orTapering Immunosuppressive Drugs

Valks¹,

Fernández‐Herrera²,

Bartolomé³

et al. 2001

Arch Dermatol

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Section: Discussionmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

Late Appearance of Acute Graft-vs-Host Disease After Suspending orTapering Immunosuppressive Drugs

Valks¹,

Fernández‐Herrera²,

Bartolomé³

et al. 2001

Arch Dermatol

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“…In contrast, cGHVD has a more slowly progressive course and a wider range of clinical and pathologic features often characterized by fibrosis and scleroderma-like changes. Salivary and lacrimal gland involvement are common and more protean manifestations such as bronchiolitis and eosinophilic fascitis are well documented (15)(16)(17)(18)(19)(20)(21)(22).…”

mentioning

confidence: 99%

Target Antigens Determine Graft-versus-Host Disease Phenotype

Kaplan

Anderson²,

McNiff

et al. 2004

The Journal of Immunology

190

135

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Chronic graft-vs-host disease (cGVHD) is an increasingly frequent complication of allogeneic stem cell transplantation. Phenotypically, cGVHD differs from patient to patient; in particular, a subset of patients develops extensive cutaneous fibrosis. Similarly, graft-vs-host disease (GVHD) is distinct in inbred murine donor:recipient pairings, indicating a genetic component to disease phenotype. The B10.D2 → BALB/c (H-2d) strain pairing uniquely recapitulates key pathologic features of fibrotic human cutaneous cGVHD. To distinguish whether this genetic component is due to differences in genes that modulate immune responses or to the specific Ags targeted, we asked whether skin-dominant cGVHD also develops in the B10 → BALB.B (H-2b) and B10.BR → BALB.K (H-2k) MHC-congenic pairings. Because each MHC haplotype presents different peptides and selects different T cell repertoires, GVHD in each donor:recipient pair undoubtedly targets different Ags. We found that, in contrast to BALB/c recipients, BALB.B mice never manifested skin disease while BALB.K mice developed a modified form of skin disease. Instead, BALB.B and BALB.K recipients developed systemic GVHD which was absent in BALB/c mice. Moreover, in (B10 × B10.D2)F1 → (BALB.B × BALB/c)F1 H-2b/d transplants, recipients developed both cutaneous and systemic disease. Thus, the selection of immunodominant Ags determines the target and character of GVHD, providing insight into the genetic basis for different forms of GVHD.

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“…14,16 From an immunopathological perspective, both lichenoid and sclerodermatous GvHD seem different. 15 The outcome for both forms of chronic GvHD differs 14,15,17 and the treatments that are administered to patients have different outcomes in lichenoid and sclerodermatous GvHD. 4 A set of criteria has recently been developed to aid in the diagnosis of chronic GvHD.…”

Section: Chronic Gvhdmentioning

confidence: 99%

Phototherapy for the treatment of cutaneous graft versus host disease

Garbutcheon‐Singh

Fernández‐Peñas

2014

Aust J Dermatology

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Graft versus host disease (GvHD) occurs in half the patients who receive allogenic haematopoietic stem cell transplantation and is a major contributor for the morbidity and mortality in these patients. Immunosuppressant therapy cannot suppress all the manifestations of GvHD and new ways of treating the condition are needed. The focus of this review is the treatment of cutaneous GvHD through phototherapy. Of the six acute and ten chronic cutaneous GvHD case series examined the overall trend was that phototherapy was able to reduce the presence of cutaneous lesions of GvHD and, as a consequence, steroid use could be reduced. This provides a positive outlook for phototherapy as a treatment for cutaneous GvHD but there is a need for future studies to include larger numbers of patients in order to obtain more data.

show abstract

Lichen planus-like histopathologic characteristics in the cutaneous graft-vs-host reaction. Prognostic significance independent of time course after allogeneic bone marrow transplantation

Cited by 16 publications

References 0 publications

Late Appearance of Acute Graft-vs-Host Disease After Suspending orTapering Immunosuppressive Drugs

Late Appearance of Acute Graft-vs-Host Disease After Suspending orTapering Immunosuppressive Drugs

Target Antigens Determine Graft-versus-Host Disease Phenotype

Phototherapy for the treatment of cutaneous graft versus host disease

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