Lichen planus and hepatitis C virus--related chronic active hepatitis

Jubert, C.

doi:10.1001/archderm.130.1.73

Cited by 65 publications

(45 citation statements)

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“…Furthermore, there is strong evidence linking HCV infection to the risk of developing hepatocellular carcinoma [7,8]. The risk of hepatocellular carcinoma has been estimated to be 3%-7.8% per year among patients with HCV-associated liver cirrhosis [5,8].HCV also has been associated with the occurrence of several extrahepatic diseases [1,4], such as mixed essential cryoglobulinemia [9], porphyria cutanea tarda [10], polyarteritis nodosa [11], sicca-like syndrome [12], and lichen planus [13]. The general pathologic mechanisms for such diseases are suggested to be either immunologically mediated or directly related to viral…”

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confidence: 99%

“…HCV also has been associated with the occurrence of several extrahepatic diseases [1,4], such as mixed essential cryoglobulinemia [9], porphyria cutanea tarda [10], polyarteritis nodosa [11], sicca-like syndrome [12], and lichen planus [13]. The general pathologic mechanisms for such diseases are suggested to be either immunologically mediated or directly related to viral…”

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confidence: 99%

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A Follow‐Up Study of Morbidity and Mortality Associated with Hepatitis C Virus Infection and Its Interaction with Human T Lymphotropic Virus Type I in Miyazaki, Japan

Boschi-Pinto¹,

Stuver²,

Okayama³

et al. 2000

J INFECT DIS

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A follow-up study was performed to analyze the effects of hepatitis C virus (HCV) infection on morbidity and mortality in the adult population from a village in Japan found to have endemic levels of both HCV and human T lymphotropic virus type I (HTLV-I). By use of the Cox proportional hazards model, rate ratios (RRs) and 95% confidence intervals (CIs) were estimated. Strong, significant effects of seropositivity for antibodies to HCV on self-reported incident liver disease (RR, 3.5; 95% CI, 1.9-6.4) and on death due to liver cancer (RR, 8.2; 95% CI, 1.6-41.4) were observed. Dual infection with HCV and HTLV-I seemed to have a synergistic effect on incident liver disease (RR, 5.9) as well as on death from liver cancer (RR, 21.9). HCV infection also was positively, although not significantly, associated with reported incident diabetes. Our findings suggest that coinfection with HTLV-I may affect the course of HCV-associated disease.

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confidence: 99%

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confidence: 99%

A Follow‐Up Study of Morbidity and Mortality Associated with Hepatitis C Virus Infection and Its Interaction with Human T Lymphotropic Virus Type I in Miyazaki, Japan

Boschi-Pinto¹,

Stuver²,

Okayama³

et al. 2000

J INFECT DIS

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“…Another study from France also supports an association [26]. Authors from Japan claimed that HCV infection might be the most important factor for OLP development [12,13,27].This Japanese group published a higher prevalence of anti-HCV antibodies in patients with oral malignancies [28].…”

Section: Discussionmentioning

confidence: 69%

Oral Lichen Planus in Patients with Chronic Liver Diseases*

et al. 2003

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“…The association of LP with chronic liver disease, especially chronic active hepatitis, primary biliary cirrhosis or cirrhosis of unknown cause, is well established [6]. In a case-control study, a twofold increase in risk for LP in HBsAg-positive patients was found compared with HBsAg-negative ones [7].…”

Section: Discussionmentioning

confidence: 99%

Papulonodular Lichenoid and Pseudolymphomatous Reaction at the Injection Site of Hepatitis B Virus Vaccination

et al. 2002

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Immunization with the hepatitis B virus (HBV) is effective and safe with an estimated incidence of adverse reactions, either local or systemic, of less than 0.1%. Cutaneous side effects are rare and include lichen planus (LP) and lichenoid reactions. We report the case of a 21-year-old female, in whom a persistent, papulonodular lesion developed at the site of the injection, 6 weeks after the second dose of the HBV. Histological examination revealed lichenoid and pseudolymphomatous features. In addition, sensitization to thiomersal, a vaccine constituent, was documented by patch testing. The association of LP with chronic liver disease is well established. Furthermore, less than 20 cases of lichen or lichenoid reactions, following HBV vaccination, have been reported. Although several arguments have been presented, it is still debated whether there is a causal association or the occurrence of LP following HBV vaccination is a simple coincidence. It has been speculated that a T-cell-mediated, graft-versus-host-like reaction, triggered by a sensitizing protein, is directed against keratinocytes expressing an epitope of hepatitis B surface antigen or a similar epitope. Our case may represent a localized lichenoid reaction to HBV vaccination, a local reactive hyperplasia or a persisting delayed hypersensitivity reaction to a vaccine constituent. This is the first case of a local lichenoid reaction at the injection site of the HBV vaccine, providing further documentation for a causal association linking the HBV vaccine with LP.

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Lichen planus and hepatitis C virus--related chronic active hepatitis

Cited by 65 publications

References 0 publications

A Follow‐Up Study of Morbidity and Mortality Associated with Hepatitis C Virus Infection and Its Interaction with Human T Lymphotropic Virus Type I in Miyazaki, Japan

A Follow‐Up Study of Morbidity and Mortality Associated with Hepatitis C Virus Infection and Its Interaction with Human T Lymphotropic Virus Type I in Miyazaki, Japan

Oral Lichen Planus in Patients with Chronic Liver Diseases*

Papulonodular Lichenoid and Pseudolymphomatous Reaction at the Injection Site of Hepatitis B Virus Vaccination

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