Lewis histo‐blood group system phenotyping and genotyping reveal divergence in the association of Le(a−b−) phenotype and type 1 diabetes

Previato, Mariana; Borim, M.P.; Liberatore, Raphael Del Roio; Pires, António; Dias, Marcílio; Mattos, Cinara Cássia Brandão de; Mattos, L. C. de

doi:10.1111/vox.12211

Cited by 4 publications

(3 citation statements)

References 22 publications

(38 reference statements)

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“…Le(a−b−) can be secretor or non-secretor. However, due to potential cross-reactivity between anti-Le a and anti-Le b antisera and even the weak adsorption of Le a and Le b carbohydrates in the red blood cell membrane, this correlation is not always true, particularly in diseases 17, 18…”

Section: Introductionmentioning

confidence: 99%

“…However, the results are affected by the method used and the quality of antisera and can be inaccurate especially in relation to the Lewis histo-blood group system 15, 17. Therefore, red cell serology techniques alone are not sufficient to characterize the structural diversity of histo-blood group carbohydrates in tissues and exocrine secretions.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, red cell serology techniques alone are not sufficient to characterize the structural diversity of histo-blood group carbohydrates in tissues and exocrine secretions. As the genes of these histo-blood group systems all interact, the combination of serology and genotyping is a good strategy to predict the diversity of carbohydrates expressed in tissues and exocrine secretions 17 . Additionally, immunochemistry, proton nuclear magnetic resonance (NMR) imaging and mass spectrometry (MALDI and Q-TofMS/MS) are useful tools to resolve the carbohydrate structure and diversity; however, these techniques and some of the reagents required are not routinely available 2 …”

Section: Introductionmentioning

confidence: 99%

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Structural diversity and biological importance of ABO, H, Lewis and secretor histo-blood group carbohydrates

Mattos

2016

Revista Brasileira de Hematologia e Hemoterapia

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ABO, H, secretor and Lewis histo-blood system genes control the expression of part of the carbohydrate repertoire present in areas of the body occupied by microorganisms. These carbohydrates, besides having great structural diversity, act as potential receptors for pathogenic and non-pathogenic microorganisms influencing susceptibility and resistance to infection and illness. Despite the knowledge of some structural variability of these carbohydrate antigens and their polymorphic levels of expression in tissue and exocrine secretions, little is known about their biological importance and potential applications in medicine. This review highlights the structural diversity, the biological importance and potential applications of ABO, H, Lewis and secretor histo-blood carbohydrates.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Structural diversity and biological importance of ABO, H, Lewis and secretor histo-blood group carbohydrates

Mattos

2016

Revista Brasileira de Hematologia e Hemoterapia

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FUT3 and FUT2 genotyping and glycoconjugate profile Lewisb as a protective factor to Toxoplasma gondii infection

et al. 2019

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ABO, Secretor and Lewis histo-blood group systems influence the digestive form of Chagas disease

Bernardo

Camargo

Ronchi

et al. 2016

Infection, Genetics and Evolution

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Chagas disease, caused by Trypanosoma cruzi, can affect the heart, esophagus and colon. The reasons that some patients develop different clinical forms or remain asymptomatic are unclear. It is believed that tissue immunogenetic markers influence the tropism of T. cruzi for different organs. ABO, Secretor and Lewis histo-blood group systems express a variety of tissue carbohydrate antigens that influence the susceptibility or resistance to diseases. This study aimed to examine the association of ABO, secretor and Lewis histo-blood systems with the clinical forms of Chagas disease. We enrolled 339 consecutive adult patients with chronic Chagas disease regardless of gender (cardiomyopathy: n=154; megaesophagus: n=119; megacolon: n=66). The control group was composed by 488 healthy blood donors. IgG anti-T. cruzi antibodies were detected by ELISA. ABO and Lewis phenotypes were defined by standard hemagglutination tests. Secretor (FUT2) and Lewis (FUT3) genotypes, determined by Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), were used to infer the correct histo-blood group antigens expressed in the gastrointestinal tract. The proportions between groups were compared using the χ2 test with Yates correction and Fisher's exact test and the Odds Ratio (OR) and 95% Confidence Interval (95% CI) were calculated. An alpha error of 5% was considered significant with p-values <0.05 being corrected for multiple comparisons (pc). No statistically significant differences were found for the ABO (X: 2.635; p-value=0.451), Secretor (X: 0.056; p-value=0.812) or Lewis (X: 2.092; p-value=0.351) histo-blood group phenotypes between patients and controls. However, B plus AB Secretor phenotypes were prevalent in pooled data from megaesophagus and megacolon patients (OR: 5.381; 95% CI: 1.230-23.529; p-value=0.011; pc=0.022) in comparison to A plus O Secretor phenotypes. The tissue antigen variability resulting from the combined action of ABO and Secretor histo-blood systems is associated with the digestive forms of Chagas disease.

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Lewis histo‐blood group system phenotyping and genotyping reveal divergence in the association of Le(a−b−) phenotype and type 1 diabetes

Abstract: The Lewis red blood cell phenotyping and genotyping reveal divergence in the association of Le(a-b-) phenotype and type 1 diabetes.

Cited by 4 publications

References 22 publications

Structural diversity and biological importance of ABO, H, Lewis and secretor histo-blood group carbohydrates

Structural diversity and biological importance of ABO, H, Lewis and secretor histo-blood group carbohydrates

FUT3 and FUT2 genotyping and glycoconjugate profile Lewisb as a protective factor to Toxoplasma gondii infection

ABO, Secretor and Lewis histo-blood group systems influence the digestive form of Chagas disease

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