2013
DOI: 10.1371/journal.pone.0073758
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Abstract: IntroductionTemporary occlusion of the hepatoduodenal ligament leads to an ischemic-reperfusion (IR) injury in the liver. Levosimendan is a new positive inotropic drug, which induces preconditioning-like adaptive mechanisms due to opening of mitochondrial KATP channels. The aim of this study was to examine possible protective effects of levosimendan in a rat model of hepatic IR injury.Material and MethodsLevosimendan was administered to male Wistar rats 1 hour (early pretreatment) or 24 hours (late pretreatmen… Show more

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Cited by 13 publications
(12 citation statements)
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“…Thus, taken together, the results of this study show that levosimendan can protect the liver against oxidative stress through the same mechanisms found in the heart and kidneys. These findings are also in agreement with those obtained from a rat model of 60 minutes of ischemia and 24 hours of reperfusion …”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Thus, taken together, the results of this study show that levosimendan can protect the liver against oxidative stress through the same mechanisms found in the heart and kidneys. These findings are also in agreement with those obtained from a rat model of 60 minutes of ischemia and 24 hours of reperfusion …”
Section: Discussionsupporting
confidence: 92%
“…These findings are also in agreement with those obtained from a rat model of 60 minutes of ischemia and 24 hours of reperfusion. 50 Although not clearly established, some speculations about the interplay of the hypothesized mechanisms of action at the basis of the protective effects of levosimendan can be made. As discussed in previous articles, 22,23 the starting point could be the mitoK ATP channel opening, which would block mitochondrial permeability transition pore functioning and thus prevent the loss of membrane potential.…”
Section: Discussionmentioning
confidence: 99%
“…For example, amlodipine blocks the uptake of mitochondrial Ca 2+ and inhibits Ca 2+ ‐induced MPT . Pre‐treatment with levosimendan, a calcium sensitizer, significantly enhances hepatic microcirculation and decreases histological damage, the serum aminotransferase level, DNA damage and liver redox homeostasis . Additionally, levosimendan suppresses the release of Bax, caspase‐9, AKT and endothelial nitric oxide synthase (eNOS) in hepatic IR models; oxidative damage induced by hepatic IR injury have also been found to be attenuated in a dose‐dependent manner .…”
Section: Pharmacological Pre‐conditioning Before Hepatic Irmentioning
confidence: 99%
“…Ebbéli antiischaemiás, gyulladásgátló hatása saját kísér-letünkben is igazolódott, ahol a "korai" (1-3 órás), illetve "késői" (24 órás) preoperatív előkezelés a máj I-R károsodásának csökkenéséhez vezetett. Szembetűnő a levosimendan -kutatócsoportunk által kifejlesztett [31] -NAD-tetrazólium festéssel igazolt mitokondriumviabilitást megőrző hatása, amely áttételesen elkép-zelhető, hogy a mitokondriálisan létrejött szabadgyök-termelés csökkentésével vezetett a redoxpanel szignifi káns javulásához [32]. Szintén kémiai kondicionálószer az adenozin (illetve az inozin), amelynek dokumentált, receptoriális (dominánsan A 2A ) receptoraktivációját, illetve ezt követő ic.…”
Section: Kondicionáló Eljárások éS Máj Ischaemiareperfúzió -áLlatkíséunclassified