Levodopa for the treatment of restless legs syndrome

Sleep Issues in Parkinson's Disease and Their Management

“…Similar results have been produced in another RCT [116]. Levodopa has also been used for treatment of RLS with good results, though much of evidence supporting its use is based on early case series and randomized controlled trials that do not employ the IRLS scale [117,118]. A meta-analysis of Fig.…”

“…Second-line and experimental therapies include cholinesterase inhibitor medications, memantine, gabapentin, pramipexole, and sodium oxybate, though evidence is limited for all of these agents. *Suggested first-line therapies levodopa use in RLS demonstrated a significant improvement of RLS severity compared to placebo using CGI-I (p < 0.0001), confirming its efficacy in the short term [118]. Interestingly, there was clinically significant improvement of RLS symptoms with placebo in many of the above trials which highlights the suggestibility of this disorder.…”

Sleep Issues in Parkinson's Disease and Their Management

“…Similar results have been produced in another RCT [116]. Levodopa has also been used for treatment of RLS with good results, though much of evidence supporting its use is based on early case series and randomized controlled trials that do not employ the IRLS scale [117,118]. A meta-analysis of Fig.…”

“…Second-line and experimental therapies include cholinesterase inhibitor medications, memantine, gabapentin, pramipexole, and sodium oxybate, though evidence is limited for all of these agents. *Suggested first-line therapies levodopa use in RLS demonstrated a significant improvement of RLS severity compared to placebo using CGI-I (p < 0.0001), confirming its efficacy in the short term [118]. Interestingly, there was clinically significant improvement of RLS symptoms with placebo in many of the above trials which highlights the suggestibility of this disorder.…”

Commentary

“…[2] Several case reports have been published previously that describe restlessness of the arms as initial presentation of RLS, however, in these cases, both arms were affected. [3][4][5] The patient in this case was also diagnosed with depression and bilateral cervical ribs. The symptoms of depression were not determined to be a cause of the RLS symptoms due to temporal association.…”

Novel Exercises for Restless Legs Syndrome: A Randomized, Controlled Trial

“…This worsening of symptoms 2 is associated with dopamine agonists 7 and levodopa. 8,9 Many people with RLS therefore seek alternate nonpharmacological options. However, high-quality guidelines published by Aurora et al 10 (AGREE assessment "recommended" 11 ) concluded that there was insufficient evidence for nonpharmacological therapy.…”

Sleep Issues in Parkinson's Disease and Their Management

“…Similar results have been produced in another RCT [116]. Levodopa has also been used for treatment of RLS with good results, though much of evidence supporting its use is based on early case series and randomized controlled trials that do not employ the IRLS scale [117,118]. A meta-analysis of Fig.…”

“…Second-line and experimental therapies include cholinesterase inhibitor medications, memantine, gabapentin, pramipexole, and sodium oxybate, though evidence is limited for all of these agents. *Suggested first-line therapies levodopa use in RLS demonstrated a significant improvement of RLS severity compared to placebo using CGI-I (p < 0.0001), confirming its efficacy in the short term [118]. Interestingly, there was clinically significant improvement of RLS symptoms with placebo in many of the above trials which highlights the suggestibility of this disorder.…”

Commentary

“…[2] Several case reports have been published previously that describe restlessness of the arms as initial presentation of RLS, however, in these cases, both arms were affected. [3][4][5] The patient in this case was also diagnosed with depression and bilateral cervical ribs. The symptoms of depression were not determined to be a cause of the RLS symptoms due to temporal association.…”

Novel Exercises for Restless Legs Syndrome: A Randomized, Controlled Trial

“…This worsening of symptoms 2 is associated with dopamine agonists 7 and levodopa. 8,9 Many people with RLS therefore seek alternate nonpharmacological options. However, high-quality guidelines published by Aurora et al 10 (AGREE assessment "recommended" 11 ) concluded that there was insufficient evidence for nonpharmacological therapy.…”

Sleep Issues in Parkinson's Disease and Their Management

“…Similar results have been produced in another RCT [116]. Levodopa has also been used for treatment of RLS with good results, though much of evidence supporting its use is based on early case series and randomized controlled trials that do not employ the IRLS scale [117,118]. A meta-analysis of Fig.…”

“…Second-line and experimental therapies include cholinesterase inhibitor medications, memantine, gabapentin, pramipexole, and sodium oxybate, though evidence is limited for all of these agents. *Suggested first-line therapies levodopa use in RLS demonstrated a significant improvement of RLS severity compared to placebo using CGI-I (p < 0.0001), confirming its efficacy in the short term [118]. Interestingly, there was clinically significant improvement of RLS symptoms with placebo in many of the above trials which highlights the suggestibility of this disorder.…”

Commentary

“…[2] Several case reports have been published previously that describe restlessness of the arms as initial presentation of RLS, however, in these cases, both arms were affected. [3][4][5] The patient in this case was also diagnosed with depression and bilateral cervical ribs. The symptoms of depression were not determined to be a cause of the RLS symptoms due to temporal association.…”

Novel Exercises for Restless Legs Syndrome: A Randomized, Controlled Trial

“…This worsening of symptoms 2 is associated with dopamine agonists 7 and levodopa. 8,9 Many people with RLS therefore seek alternate nonpharmacological options. However, high-quality guidelines published by Aurora et al 10 (AGREE assessment "recommended" 11 ) concluded that there was insufficient evidence for nonpharmacological therapy.…”