Leveraging microtopography to pattern multi-oriented muscle actuators
Tamara Rossy,
Laura Schwendeman,
Maheera Bawa
et al.
Abstract:Engineering skeletal muscle tissue with precisely defined alignment is of significant importance for applications ranging from drug screening to biohybrid robotics. Aligning 2D contractile muscle monolayers, which are compatible with high-content imaging and can be deployed in planar soft robots, typically require micropatterned cues. However, current protocols for integrating microscale topographical features in extracellular matrix hydrogels require expensive microfabrication equipment and multi-step procedu… Show more
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