Levels of serum pentraxin 3, IL-6, fetuin A and insulin in patients with rheumatoid arthritis

Tekeoğlu, İbrahim; Harman, Halil; Sağ, Sinem; Altındiş, Mustafa; Kamanlı, Ayhan; Nas, Kemal

doi:10.1016/j.cyto.2016.04.009

Cited by 34 publications

(24 citation statements)

References 30 publications

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“…Recent studies have shown that PTX3 levels are higher in patients with RA than controls. 30 However, there was no correlation between PTX3 and DAS28. We also found that the PTX3 level in the RA group was higher than the control group.…”

Section: Discussionmentioning

confidence: 75%

“…The imbalance between proand anti-inflammatory cytokines supports the onset of autoimmune, chronic inflammation and consequently joint damage. 30 Of the proinflammatory cytokines, which play an important role in the pathogenesis of RA, IL-6 has been detected at high rates in the synovial fluid of RA patients and this elevation has been found to be correlated with disease activity and joint damage. 31,32 In our study, IL-6 level was higher in RA group.…”

Section: Discussionmentioning

confidence: 99%

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The Relationship Between Serum Pentraxine 3 Levels and Hematological Markers in Patients With Rheumatoid Arthritis

Sağ

Tekeoğlu

et al. 2018

Arch Rheumatol

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Objectives: This study aims to investigate the association of pentraxin 3 (PTX3) with neutrophil/lymphocyte ratio (NLR) rather than the disease activity score 28 using C-reactive protein in rheumatoid arthritis (RA). Patients and methods:The study included 59 RA patients (11 males, 48 females; mean age 53.79±13.55 years; range 40 to 66 years) and 20 healthy controls (5 males, 15 females; mean age 50.41±6.11 years; range 43 to 56 years). Complete blood count tests were recorded and NLR and platelet/lymphocyte ratio were calculated. PTX3 and interleukin-6 levels were examined in serum samples. Disease activity of RA patients was assessed by disease activity score 28. Results: Demographic characteristics were similar between the two groups, with no statistically significant difference in terms of sex, age, and body mass index (p>0.05). NLR, PTX3 and interleukin-6 levels were higher in patients with RA than the control group (p<0.05). While erythrocyte sedimentation rate had a positive correlation with mean platelet volume, we found no correlation between NLR and other parameters of disease activity, PTX3, and interleukin-6. Conclusion: We found no correlation between PTX3 and disease activity score 28 or NLR, although PTX3 levels were higher in RA patients than the controls. As a result, we were unable to establish a relationship between PTX3 and disease activity, directly or indirectly. To our knowledge, our study was the first to investigate the relationship between PTX3 and NLR.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

The Relationship Between Serum Pentraxine 3 Levels and Hematological Markers in Patients With Rheumatoid Arthritis

Sağ

Tekeoğlu

et al. 2018

Arch Rheumatol

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“…Periodontitis and rheumatoid arthritis are chronic inflammatory conditions with similar pathological features. Fetuin‐A was thought to play a role in the pathogenesis of rheumatoid arthritis (Sato et al, ; Vassalle & Mazzone, ), but fetuin‐A levels were found to decrease in patients with rheumatoid arthritis (Saroha, Kumar, Chatterjee, & Das, ; Tekeoglu et al, ). In a study by Türer et al (), which was the only study that examined the relationship between fetuin‐A and periodontal diseases, the serum and GCF fetuin‐A levels decreased significantly as the severity of periodontal disease increased, consistent with the results of our study.…”

Section: Discussionmentioning

confidence: 99%

Salivary fetuin‐A, S100A12, and high‐sensitivity C‐reactive protein levels in periodontal diseases

et al. 2018

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“…Кроме того, в своей работе они указали на отсутствие взаимосвязи между уровнем ФА и наличием аортальной кальцификации, связав последнюю с кумулятивной дозой ГК. Имеются единичные работы, в которых взаимосвязь между уровнем ФА и показателями активности РА обнаружена не была, что указывает на необходимость дальнейшего изучения данного вопроса [17,18]. Также следует отметить, что средний уровень ФА в группе условно здоровых лиц различался в данных исследованиях.…”

Section: Discussionunclassified

Serum Fetuin-a Levels in Patients With Rheumatoid Arthritis

Papichev¹,

Заводовский²,

Sivordova³

et al. 2019

Naučno-praktičeskaâ revmatologiâ

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Rheumatoid arthritis (RA) is the second most common rheumatic disease. In recent decades, there has been an active search for and study of biologically active substances involved in the pathogenesis of RA, which can serve as a starting point in designing new drugs for targeted therapy of this disease. The hepatokine fetuin-A (FA) is one of these substances.Objective: to investigate serum FA levels in patients with RA.Subjects and methods. The investigation enrolled 110 patients with RA. All the patients underwent the following set of studies: general blood test and determination of the serum levels of C-reactive protein (CRP), serum FA, rheumatoid factor, anti-cyclic citrullinated peptide (anti-CCP) antibodies, cartilage degradation products (CartiLaps), and urine creatinine. A control group consisted of 30 apparently healthy individuals whose serum FA level was determined in order to obtain reference values.Results and discussion. The normal FA level varied from 653.55 to 972.19 μg/ml. All the patients with RA were divided into two groups: 1) 23 patients with a low FA level (<653.55 μg/ml) and 2) 87 patients with a normal FA levels (≥653.55 μg/ml). The groups differed significantly in anti-CCP antibody concentrations, disease activity, radiological stages, functional classes, and the presence of complications. Patients with lower FA levels were noted to have increased CRP concentrations, erythrocyte sedimentation rate, and CartiLaps/urine creatinine ratio. The mean FA concentration was considerably and significantly lower in patients with higher DAS28 scores. Conclusion. Our investigation has revealed that there is a relationship between the levels of FA and the individual clinical manifestations of RA. The lower FA level is associated with higher disease activity and the aggressive phenotype of RA (the presence of anti-CCP antibodies, radiological stages III and IV, extra-articular manifestations and complications).

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Levels of serum pentraxin 3, IL-6, fetuin A and insulin in patients with rheumatoid arthritis

Cited by 34 publications

References 30 publications

The Relationship Between Serum Pentraxine 3 Levels and Hematological Markers in Patients With Rheumatoid Arthritis

The Relationship Between Serum Pentraxine 3 Levels and Hematological Markers in Patients With Rheumatoid Arthritis

Salivary fetuin‐A, S100A12, and high‐sensitivity C‐reactive protein levels in periodontal diseases

Serum Fetuin-a Levels in Patients With Rheumatoid Arthritis

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