Levels of five biochemical parameters in asthmatic patient’s blood as markers for bronchial asthma induced by the house-dust mite allergy

El-Zohery, Yousry Z. A.; Kenawy, M. A.; Awad, Ashraf A.; Helmi, Nadia; El-Shafei, Akila M.; Abdel-Hamid, Yousrya M.

doi:10.21608/eajbsc.2012.16122

Cited by 3 publications

(2 citation statements)

References 17 publications

(19 reference statements)

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“…In bronchial asthma group, mean AEC increased with the increasing severity of asthma. This finding was in accordance with the finding of many previous studies done by El-Zohery et al in [12] and Devi et al in [13].…”

Section: Discussionsupporting

confidence: 94%

Association of Serum Neutrophil Gelatinase-Associated Lipocalin with Childhood Asthma in Benha University Hospitals

Sabra

Faied²,

Arafa³

et al. 2022

Benha Journal of Applied Sciences

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Background: In various nations, asthma affects 1-18% of the population. It is a common, chronic respiratory condition. Fluctuating wheezing, shortness of breath, chest tightness, and/or coughing symptoms, as well as variable expiratory airflow limitation, are the hallmarks of bronchial asthma. The aim of the study was to evaluate the association of serum NGAL with childhood bronchial asthma for diagnosis, prognosis and assessment of severity. Methods: This prospective, cross-sectional study was conducted on 40 asthmatic cases. Cases were subdivided into four asthma groups (intermittent, mild persistent, moderate persistent and severe persistent) and 20 healthy children representing the control group. Cases were subjected to history taking, Routine Laboratory investigations, special laboratory investigations as serum NGAL level. NGAL concentrations were determined with Human Neutrophil -Gelatinase -Associated Lipocalin (NGAL) ELISA Kit. Results: NGAL showed significant positive correlations with eosinophil (r = 0.676, P < 0.001), CRP (r = 0.729, P < 0.001), and asthma severity (r = 0.712, P < 0.001), while it showed significant negative correlations with FEV 1 (r = -0.723, P < 0.001) and FEV/FVC (r = -0.767, P < 0.001). No significant correlations were detected with other parameters. ROC analysis was done for NGAL to distinguish severe cases. It revealed a significant AUC of 0.945 with a 95% CI ranging from 0.841 -1 (P < 0.001). The best cut-off point was > 190, at which sensitivity and specificity were 87.5% and 100%, respectively. Conclusions: Serum NGAL level seems to be significantly elevated in asthmatic children and can be related to asthma severity.

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Section: Discussionsupporting

confidence: 94%

Association of Serum Neutrophil Gelatinase-Associated Lipocalin with Childhood Asthma in Benha University Hospitals

Sabra

Faied²,

Arafa³

et al. 2022

Benha Journal of Applied Sciences

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“…In the current study, the absolute eosinophilic count was significantly higher in the asthmatic children compared to the healthy control group ( p < 0.001). This conformed with the results of El-Zohery et al who tested eosinophilic count as one of the five biochemical markers in asthmatic children’s blood as parameters for bronchial asthma induction due to house-dust mite allergy [17]. This could be explained by the fact that in cases of atopic asthma, Th2 cells are activated with a subsequent release of IL-15 with the resultant enhancement of eosinophilia [18].…”

Section: Discussionsupporting

confidence: 84%

Genetic association of interleukin 18 (-607C/A, rs1946518) single nucleotide polymorphism with asthmatic children, disease severity and total IgE serum level

Ezzat

Morgan

Mohamed

et al. 2019

cejoi

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IntroductionBronchial asthma is a chronic inflammatory disease. Interleukin 18 (IL-18) single nucleotide polymorphisms (SNPs) can influence IL-18 production and activity. IL-18-607C/A and -137 C/G are two of the commonly studied SNPs of IL-18 due to their role in the etiopathogenesis of allergic diseases.Aim of the studyThe case control study was conducted to investigate the genetic association between IL-18-607C/A polymorphism and pediatric asthma. Also attempts were made to evaluate the prognostic effect of -607C/A SNP with disease severity and total serum IgE.Material and methodsThe case control study was conducted on 60 asthmatic children and 40 healthy subjects; aged 2 to 12 years. PCR-RFLP was used to detect IL-18-607C/A SNP and total serum IgE level was detected using ELISA technique.ResultsRegarding IL-18-607C/A SNP, the frequency of the A allele and CA genotype was significantly higher in asthmatic children compared to healthy control subjects (p < 0.001). Further on, asthmatic children carrying the AA/AC genotype of -607C/A SNP were associated with an increased risk of occurrence of asthma (OR = 6.417; CI = 2.432-17.289). IgE was higher in asthmatic patients carrying the heterozygous CA genotype compared to patients carrying the AA and CC genotypes (p = 0.054).ConclusionThe frequency of the heterozygous CA genotype and A allele in IL-18-607C/A SNP was higher in asthmatic children. There is no association between the severity of asthma and -607C/A SNP. Total IgE was higher in patients carrying the CA genotypes compared to patients carrying the AA and CC genotypes, respectively.

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Comparison of total serum immunoglobulin E and absolute eosinophil count levels among asthmatic and non-asthmatic children

Chaudhary¹,

Kumar²,

Shashtri³

et al. 2017

Indian J Child Health

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Background: Immunoglobulin E (IgE) and associated cellular responses such as absolute eosinophil count (AEC) are responsible for allergic airway diseases. A hypersensitivity reaction initiated by immunological mechanisms, mediated by IgE antibodies, and eosinophils occur in allergic asthma. Objective: To compare the total serum IgE level and AEC levels among asthmatic and non-asthmatic children. Methods: The present study was conducted in the department of pediatrics and TB and Chest of a Medical College of North India from October 2015 to November 2016. Children from 3 years to 18 years, 30 with bronchial asthma and 30 healthy children were included in this study randomly. Results: The mean total serum IgE level in children with bronchial asthma was significantly higher (700.97±571.01 IU/ml) than that in healthy children (189.33±14.29 IU/ml). The mean AEC was also significantly higher in cases (746.63±492.02 cells/mm3) as compared to healthy children (220.23±121.69 cells/mm3). In bronchial asthma group, mean AEC increased with the increasing severity of asthma. Conclusion: The elevated level of total serum IgE and AEC may demonstrate the allergic etiology of asthma and hence, estimation of serum IgE and AEC levels can be considered as laboratory investigations in diagnosing cases of bronchial asthma.

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Levels of five biochemical parameters in asthmatic patient’s blood as markers for bronchial asthma induced by the house-dust mite allergy

Cited by 3 publications

References 17 publications

Association of Serum Neutrophil Gelatinase-Associated Lipocalin with Childhood Asthma in Benha University Hospitals

Association of Serum Neutrophil Gelatinase-Associated Lipocalin with Childhood Asthma in Benha University Hospitals

Genetic association of interleukin 18 (-607C/A, rs1946518) single nucleotide polymorphism with asthmatic children, disease severity and total IgE serum level

Comparison of total serum immunoglobulin E and absolute eosinophil count levels among asthmatic and non-asthmatic children

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