Leukotrienes and α-naphthylisothiocyanate-induced liver injury

Isolation and some properties of dioxygenase and co-oxidase activities of adult human liver cytosolic lipoxygenase

“…Similar observations have been noted for mice following a chronic exposure to this hepatotoxicant (17). In a recent study (18), A-63162, a LO inhibitor, was found to attenuate the hepatic parenchymal injury and resulted in a modest decrease in the hepatic cholestasis caused by ␣-naphthylisothiocyanate pretreatment.…”

Isolation and some properties of dioxygenase and co-oxidase activities of adult human liver cytosolic lipoxygenase

“…Similar observations have been noted for mice following a chronic exposure to this hepatotoxicant (17). In a recent study (18), A-63162, a LO inhibitor, was found to attenuate the hepatic parenchymal injury and resulted in a modest decrease in the hepatic cholestasis caused by ␣-naphthylisothiocyanate pretreatment.…”

Nitrosative Stress and Lipid Homeostasis as a Mechanism for Zileuton Hepatotoxicity and Resistance in Genetically Sensitive Mice

“…Zileuton, a medication that is commonly used for maintenance treatment of asthma, is an orally active inhibitor of 5-lipoxygenase which inhibits leukotriene synthesis (Bailie et al, 1995). The drug has been used to treat related conditions, including chronic obstructive pulmonary disease, conditions associated with upper airway inflammation, and dermatological conditions such as acne and atopic dermatitis (Sorkness, 1997).…”

Role of Neutrophils in the Pathogenesis of Acute Inflammatory Liver Injury

“…However, since blockade of these mediators by specific inhibitors did not result in abrogation of ANITinduced neutrophilic inflammation, it appears that PAF and leukotrienes are not likely involved in neutrophil infiltration (Bailie et al, 1995(Bailie et al, , 1996. CXC chemokines are other potential candidates that were investigated for ANIT-mediated inflammation.…”

“…Chemoattractants such as PAF, leukotriene B 4 and lipid peroxidation products, e.g., 4-hydroxynonenal, have been investigated as possible candidates in ANIT-mediated neutrophil infiltration (Evans et al, 1991;Henderson, 1994;Nitti et al, 2002). However, since blockade of these mediators by specific inhibitors did not result in abrogation of ANITinduced neutrophilic inflammation, it appears that PAF and leukotrienes are not likely involved in neutrophil infiltration (Bailie et al, 1995(Bailie et al, , 1996. CXC chemokines are other potential candidates that were investigated for ANIT-mediated inflammation.…”

Isolation and some properties of dioxygenase and co-oxidase activities of adult human liver cytosolic lipoxygenase

“…Similar observations have been noted for mice following a chronic exposure to this hepatotoxicant (17). In a recent study (18), A-63162, a LO inhibitor, was found to attenuate the hepatic parenchymal injury and resulted in a modest decrease in the hepatic cholestasis caused by ␣-naphthylisothiocyanate pretreatment.…”

Nitrosative Stress and Lipid Homeostasis as a Mechanism for Zileuton Hepatotoxicity and Resistance in Genetically Sensitive Mice

“…Zileuton, a medication that is commonly used for maintenance treatment of asthma, is an orally active inhibitor of 5-lipoxygenase which inhibits leukotriene synthesis (Bailie et al, 1995). The drug has been used to treat related conditions, including chronic obstructive pulmonary disease, conditions associated with upper airway inflammation, and dermatological conditions such as acne and atopic dermatitis (Sorkness, 1997).…”

Role of Neutrophils in the Pathogenesis of Acute Inflammatory Liver Injury

“…However, since blockade of these mediators by specific inhibitors did not result in abrogation of ANITinduced neutrophilic inflammation, it appears that PAF and leukotrienes are not likely involved in neutrophil infiltration (Bailie et al, 1995(Bailie et al, , 1996. CXC chemokines are other potential candidates that were investigated for ANIT-mediated inflammation.…”

“…Chemoattractants such as PAF, leukotriene B 4 and lipid peroxidation products, e.g., 4-hydroxynonenal, have been investigated as possible candidates in ANIT-mediated neutrophil infiltration (Evans et al, 1991;Henderson, 1994;Nitti et al, 2002). However, since blockade of these mediators by specific inhibitors did not result in abrogation of ANITinduced neutrophilic inflammation, it appears that PAF and leukotrienes are not likely involved in neutrophil infiltration (Bailie et al, 1995(Bailie et al, , 1996. CXC chemokines are other potential candidates that were investigated for ANIT-mediated inflammation.…”

Isolation and some properties of dioxygenase and co-oxidase activities of adult human liver cytosolic lipoxygenase

“…Similar observations have been noted for mice following a chronic exposure to this hepatotoxicant (17). In a recent study (18), A-63162, a LO inhibitor, was found to attenuate the hepatic parenchymal injury and resulted in a modest decrease in the hepatic cholestasis caused by ␣-naphthylisothiocyanate pretreatment.…”

Nitrosative Stress and Lipid Homeostasis as a Mechanism for Zileuton Hepatotoxicity and Resistance in Genetically Sensitive Mice

“…Zileuton, a medication that is commonly used for maintenance treatment of asthma, is an orally active inhibitor of 5-lipoxygenase which inhibits leukotriene synthesis (Bailie et al, 1995). The drug has been used to treat related conditions, including chronic obstructive pulmonary disease, conditions associated with upper airway inflammation, and dermatological conditions such as acne and atopic dermatitis (Sorkness, 1997).…”

Role of Neutrophils in the Pathogenesis of Acute Inflammatory Liver Injury

“…However, since blockade of these mediators by specific inhibitors did not result in abrogation of ANITinduced neutrophilic inflammation, it appears that PAF and leukotrienes are not likely involved in neutrophil infiltration (Bailie et al, 1995(Bailie et al, , 1996. CXC chemokines are other potential candidates that were investigated for ANIT-mediated inflammation.…”

“…Chemoattractants such as PAF, leukotriene B 4 and lipid peroxidation products, e.g., 4-hydroxynonenal, have been investigated as possible candidates in ANIT-mediated neutrophil infiltration (Evans et al, 1991;Henderson, 1994;Nitti et al, 2002). However, since blockade of these mediators by specific inhibitors did not result in abrogation of ANITinduced neutrophilic inflammation, it appears that PAF and leukotrienes are not likely involved in neutrophil infiltration (Bailie et al, 1995(Bailie et al, , 1996. CXC chemokines are other potential candidates that were investigated for ANIT-mediated inflammation.…”