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Cited by 303 publications
(192 citation statements)
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“…In humans, it has been suggested that increased production of cysteinyl-LT correlates with susceptibility to aspirin-intolerant asthma (37,38). Recent studies have shown that variations in the synthesis of cysteinyl-LT result from a polymorphism in the LTC 4 synthase gene promoter, which causes constitutive overexpression of this enzyme in aspirin-sensitive patients (37)(38)(39)(40). Differing expression levels of LTC 4 synthase may account for variability observed in the response to LT inhibitors used in the treatment of asthma (37).…”
Section: Discussionmentioning
confidence: 99%
“…In humans, it has been suggested that increased production of cysteinyl-LT correlates with susceptibility to aspirin-intolerant asthma (37,38). Recent studies have shown that variations in the synthesis of cysteinyl-LT result from a polymorphism in the LTC 4 synthase gene promoter, which causes constitutive overexpression of this enzyme in aspirin-sensitive patients (37)(38)(39)(40). Differing expression levels of LTC 4 synthase may account for variability observed in the response to LT inhibitors used in the treatment of asthma (37).…”
Section: Discussionmentioning
confidence: 99%
“…It has been reported that LTC4S was expressed five times more strongly in bronchial biopsies from AIA patients compared to ATA and normal controls (Cowburn et al 1998). Sanak et al (1997Sanak et al ( , 2000 showed that AIA was associated with the genetic polymorphism of LTC4S -444A>C, which has an additional responsive element to histone H4 transcription factor-2, and increases the transcription rate of the gene in vitro and in vivo in a Polish population. Furthermore, the variant C allele was not associated with mild asthmatics having AIA who did not require oral steroids to control their asthma symptoms, suggesting that it is a marker of the severe, steroid-dependent phenotype of AIA.…”
Section: Discussionmentioning
confidence: 99%
“…The genetic polymorphism of LTC4S -444A>C is strongly associated with the AIA phenotype in a Polish population, which is supported by functional data demonstrating an additional transcription factor binding site to increase the transcription rate of this gene (Sanak et al 1997(Sanak et al , 2000. In contrast, no significant associations were detected in American (Van Sambeek et al 2000), Japanese (Kawagishi et al 2002), Australian (Kedda et al 2004), or Spanish (Isidoro-García et al 2005 populations.…”
mentioning
confidence: 89%
“…Recent studies have reported associations of the genetic variations in many genes on the arachidonate, immune response and inflammation pathways, such as leukotriene C4 synthase (LTC4S), 26,27 arachidonate 5-lipoxygenase (ALOX5) 16 and MHC class II, DP beta 1 (HLA-DPB1), 25 with aspirin hypersensitivity in asthmatics. However, conflicting results of the associations between polymorphisms of the genes and AERD have been reported, suggesting that underlying mechanisms of AERD pathogenesis may be more complicated than previously thought.…”
Section: Discussionmentioning
confidence: 99%