Leukotriene B4 amplifies eosinophil accumulation in response to nematodes

Patnode, Michael L.; Bando, Jennifer K.; Krummel, Matthew F.; Locksley, Richard M.; Rosen, Steven D.

doi:10.1084/jem.20132336

Cited by 59 publications

(43 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our studies highlighted important roles for LTB4‐mediated signal relay during the formation of persistent swarms at sites of sterile skin injury and in the development of transient swarms during P. aeruginosa infection of lymph nodes . Moreover, paracrine LTB4 signaling also amplifies the collective migration and accumulation of eosinophils, another granulocyte type, in response to parasitic nematodes ( Nippostrongylus brasiliensis , Caenorhabditis elegans ) …”

Section: Swarming Of Mouse Neutrophilsmentioning

confidence: 83%

Neutrophil swarming: an essential process of the neutrophil tissue response

Kienle

Lämmermann

2016

Immunological Reviews

189

186

View full text Add to dashboard Cite

Neutrophil infiltration into inflamed and infected tissues is a fundamental process of the innate immune response. While neutrophil interactions with the blood vessel wall have been intensely studied over the last decades, neutrophil dynamics beyond the vasculature have for a long time remained poorly investigated. Recent intravital microscopy studies of neutrophil populations directly at the site of tissue damage or microbial invasion have changed our perspective on neutrophil responses within tissues. Swarm-like migration patterns of neutrophils, referred to as 'neutrophil swarming', have been detected in diverse tissues under conditions of sterile inflammation and infection with various pathogens, including bacteria, fungi, and parasites. Current work has begun to unravel the molecular pathways choreographing the sequential phases of highly coordinated chemotaxis followed by neutrophil accumulation and the formation of substantial neutrophil clusters. It is now clear that intercellular communication among neutrophils amplifies their recruitment in a feed-forward manner, which provides them with a level of self-organization during neutrophil swarming. This review will summarize recent developments and current concepts on neutrophil swarming, an important process of the neutrophil tissue response with a critical role in maintaining the balance between host protection and inflammation-driven tissue destruction.

show abstract

Section: Swarming Of Mouse Neutrophilsmentioning

confidence: 83%

Neutrophil swarming: an essential process of the neutrophil tissue response

Kienle

Lämmermann

2016

Immunological Reviews

189

186

View full text Add to dashboard Cite

show abstract

“…Interestingly, during infection with T. spiralis, which has an extended tissue-dwelling stage in the muscle, the eosinophil appears to protect the encysted larval stages, and in the absence of eosinophils, these parasites are damaged by macrophages and neutrophils (154). Moreover, eosinophils respond directly to nematode products and migrate toward nematodes both in vitro and in vivo, with a key role for leukotrienes in this process (155). Investigators have known for many years that leukotrienes are produced during GI nematode infection (156).…”

Section: Adaptive Effector Mechanismsmentioning

confidence: 99%

Immunity to Helminths: Resistance, Regulation, and Susceptibility to Gastrointestinal Nematodes

Grencis

2015

Annu. Rev. Immunol.

177

165

View full text Add to dashboard Cite

Helminth parasites are a highly successful group of pathogens that challenge the immune system in a manner distinct from rapidly replicating infectious agents. Of this group, roundworms (nematodes) that dwell in the intestines of humans and other animals are prevalent worldwide. Currently, more than one billion people are infected by at least one species, often for extended periods of time. Thus, host-protective immunity is rarely complete. The reasons for this are complex, but laboratory investigation of tractable model systems in which protective immunity is effective has provided a mechanistic understanding of resistance that is characterized almost universally by a type 2/T helper 2 response. Greater understanding of the mechanisms of susceptibility has also provided the basis for defining host immunoregulation and parasite-evasion strategies, helping place in context the changing patterns of immunological disease observed worldwide.

show abstract

“…Besides, local eosinophil accumulation has been reported to be enhanced with leukotriene through paracrine activation. [4] Thus, NSAID might exacerbate this segmental eosinophilic-mediated vasoconstriction process.…”

Section: Discussionmentioning

confidence: 99%

Acute coronary vasospasm in a patient with eosinophilic granulomatosis with polyangiitis following NSAID administration

Benallegue

Lozac’h²,

Bélizna³

et al. 2016

Medicine

View full text Add to dashboard Cite

Eosinophilic with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome) is a rare systemic disease characterized by a small-vessel necrotizing vasculitis. Cardiac manifestations are broad-ranging and are associated with a poor prognosis. Coronary vasospasm is uncommon.Here, we report a case of an acute coronary vasospasm in a patient with EGPA after corticosteroids withdrawal and nonsteroidal antiinflammatory drug (NSAID) introduction. This patient was initially misdiagnosed as bradykinin-mediated angioedema. A 30-year-old man presented with recurrence of abdominal pain and acute dyspnea. NSAID administration for pain during a flare was followed by coronary vasospasms leading to cardiac arrest. Corticosteroid treatment was recently interrupted by the patient.This case reports a rare cardiac complication of EGPA. NSAID might contribute to coronary vasospasm by eosinophilic degranulation in EGPA. Moreover, corticosteroid compliance must be emphasized among patients who display EGPA with high cardiac risk to prevent fatal issues.

show abstract

Leukotriene B4 amplifies eosinophil accumulation in response to nematodes

Abstract: Rapid eosinophil accumulation around nematode species occurs via leukotriene induction, which is necessary for nematode-induced eosinophil accumulation in the lung.

Cited by 59 publications

References 28 publications

Neutrophil swarming: an essential process of the neutrophil tissue response

Neutrophil swarming: an essential process of the neutrophil tissue response

Immunity to Helminths: Resistance, Regulation, and Susceptibility to Gastrointestinal Nematodes

Acute coronary vasospasm in a patient with eosinophilic granulomatosis with polyangiitis following NSAID administration

Contact Info

Product

Resources

About