Leukomelanoderma Subsequent to the Application of Monobenzyl Ether of Hydroquinone

Cañizares, Orlando

doi:10.1001/archderm.1958.01560020074009

Cited by 15 publications

(6 citation statements)

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“…[2][3][4][5] Negro subject in the present study had vitiligo although one did have a long standing leukoderma from previous exposure to rubber gloves containing agerite alba, the antioxidant from which MBH was originally derived.…”

mentioning

confidence: 99%

Leukoderma Following Monobenzyl Ether of Hydroquinone Bleaching

Spencer¹

1962

Arch Dermatol

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mentioning

confidence: 99%

Leukoderma Following Monobenzyl Ether of Hydroquinone Bleaching

Spencer¹

1962

Arch Dermatol

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“…Similar complete depigmentation beyond the treatment area was noted in two South American patients. Total depigmentation was noted to be common among Negroes and Asiatics but not among Caucasians (Canizares, 1958). Lack ofthe development of either hyper-or hypopigmentation in a total of 185 patients (Lerner, 1953;Ito, 1957) suggested possible patient abuse or careless transfer by fingers.…”

Section: Patient Selection and Instructionmentioning

confidence: 97%

Monobenzylether of hydroquinone.

1977

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Of 18 severely afffected vitiligo patients who used 20% monobenzylether of hydroquinone (MBEH, Benoquin) as a depigmenting agent, 8 achieved complete depigmentation after 10 months or more of use and 3 dramatic but no complete hypopigmentation. The 3 patients with no results did not use MBEH for more than 4 months. Complications were frequent particularly among those who did well, but only 1 case of contact dermatitis limited therapy. All patients who depigmented fully were very pleased with their results. As depigmentation induced by MBEH is generally irreversible, MBEH use must be reserved for induction of complete depigmentation of severely affected vitiligo patients who cannot or do not choose to repigment and who can accept the permanence of never tanning. The history, histology and mechanism of MBEH depigmentation are discussed.

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“…After this observation, others attempted to use MBEH as a treatment for hypermelanoses 4–6 , however reports of complete and irreversible depigmentation at the site of application and in remote areas limited its use 7–10 , and resulted in its removal from commercial products. The ability of MBEH to permanently remove skin pigment prompted Mosher, Lerner, and Fitzpatrick to test it as a topical treatment for patients with severe vitiligo.…”

Section: Chemicals Directly Implicated In Inducing Vitiligomentioning

confidence: 99%

Chemical-Induced Vitiligo

Harris

2017

Dermatologic Clinics

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Synopsis Chemical-induced depigmentation of the skin has been recognized for over 75 years, first as an occupational hazard but then extending to those using household commercial products as common as hair dyes. Since their discovery, these chemicals have been used therapeutically in patients with severe vitiligo to depigment their remaining skin and improve their appearance. The importance of recognizing this phenomenon was highlighted during an outbreak of vitiligo in Japan during the summer of 2013, when over 16,000 users of a new skin lightening cosmetic cream developed skin depigmentation at the site of contact with the cream and many in remote areas as well. Depigmenting chemicals appear to be analogs of the amino acid tyrosine that disrupt melanogenesis and result in autoimmunity and melanocyte destruction. Because chemical-induced depigmentation is clinically and histologically indistinguishable from non-chemically induced vitiligo, and because these chemicals appear to induce melanocyte autoimmunity, this phenomenon should be known as “chemical-induced vitiligo”, rather than less accurate terms that have been previously used.

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Leukomelanoderma Subsequent to the Application of Monobenzyl Ether of Hydroquinone

Cited by 15 publications

References 1 publication

Leukoderma Following Monobenzyl Ether of Hydroquinone Bleaching

Leukoderma Following Monobenzyl Ether of Hydroquinone Bleaching

Monobenzylether of hydroquinone.

Chemical-Induced Vitiligo

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