2017
DOI: 10.18632/aging.101293
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Abstract: Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with chronological age. One measure of DNA methylation age-the extrinsic epigenetic age acceleration (EEAA)-is highly predictive of all-cause mortality. We examined the relation between LTL and EEAA. LTL was measured by Southern blots and leukocyte DNA methylation was determined using Illumina Infinium HumanMethylation450 BeadChip in participants in the Women's Health Initiative (WHI; n=804), the Framingham Heart Study (FHS; n… Show more

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Cited by 38 publications
(35 citation statements)
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References 46 publications
(55 reference statements)
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“…Our paradoxical finding that TERT alleles associated with longer telomeres are associated with higher IEAA is substantiated by our in vitro evidence that TERT expression promotes DNAm age; this might suggest a potential trade-off between telomere length and epigenomic maintenance systems. However, we found no evidence for a broader causal inter-relationship between telomere length and IEAA, consistent with the lack of phenotypic association between these traits in our studies (WHI: r = -0.05, p=0.16; FHS: r=0.0, p=0.99, ref 39 ) and in previous reports 14,16 . Furthermore, while critically short telomere length is a well-established trigger of replicative senescence 36,[40][41][42] , the functional consequences of epigenetic ageing are yet unknown.…”
Section: Discussionsupporting
confidence: 91%
“…Our paradoxical finding that TERT alleles associated with longer telomeres are associated with higher IEAA is substantiated by our in vitro evidence that TERT expression promotes DNAm age; this might suggest a potential trade-off between telomere length and epigenomic maintenance systems. However, we found no evidence for a broader causal inter-relationship between telomere length and IEAA, consistent with the lack of phenotypic association between these traits in our studies (WHI: r = -0.05, p=0.16; FHS: r=0.0, p=0.99, ref 39 ) and in previous reports 14,16 . Furthermore, while critically short telomere length is a well-established trigger of replicative senescence 36,[40][41][42] , the functional consequences of epigenetic ageing are yet unknown.…”
Section: Discussionsupporting
confidence: 91%
“…Like other studies, we found no associations between epigenetic aging and telomere length [ 47 ]. A recent study, however, did find an inverse association between telomere length and advanced epigenetic aging, possibly as a result a high memory CD8+ T cells/naive CD8+ T cells ratio [ 48 ].…”
Section: Discussionmentioning
confidence: 99%
“…homeostatic dysregulation, Klemer and Doubal's method and Levine's method), but not with telomere length. Other 3 50 55 60 65 70 studies showed that telomere length was not correlated with epigenetic age 7,21 , although cell type composition adjustments revealed a modest association 22 . Further, both Hannum and Horvath epigenetic clocks 23,24 showed modest correlations to a transcriptomic clock 17 .…”
Section: Introductionmentioning
confidence: 97%