Leukocyte Migration Inhibition by Brain Tissue Antigens in Acute Inflammatory Diseases of the Nervous System

Lymphocyte transformation in the presence of myelin basic protein in multiple sclerosis and control subjects

“…Two groups obtained positive results in patients with other neurological disease as well as in MS (Rocklin 1972, Minderhoud et al 1978. There is complete conflict of results with the capillary tube technique since positive results were found in MS but not other neurological disease by Myers & Ellison (1976), negative results in both groups by Strandgaard & Jorgenson (1972), positive results in other neurological disease by Nyerges et al (1974) and equivocal results in MS by . Interpretation of this test is unusually complicated because both stimulation and inhibition are regarded as indicating positive results.…”

“…In summary, positive results were obtained with the agarose technique by Kiillen's group in both MS and other neurological disease, and there was no clear correlation with the stage of disease in MS. There is complete conflict of results with the capillary tube technique since positive results were found in MS but not other neurological disease by Myers & Ellison (1976), negative results in both groups by Strandgaard & Jorgenson (1972), positive results in other neurological disease by Nyerges et al (1974) and equivocal results in MS by .…”

Lymphocyte transformation in the presence of myelin basic protein in multiple sclerosis and control subjects

“…Two groups obtained positive results in patients with other neurological disease as well as in MS (Rocklin 1972, Minderhoud et al 1978. There is complete conflict of results with the capillary tube technique since positive results were found in MS but not other neurological disease by Myers & Ellison (1976), negative results in both groups by Strandgaard & Jorgenson (1972), positive results in other neurological disease by Nyerges et al (1974) and equivocal results in MS by . Interpretation of this test is unusually complicated because both stimulation and inhibition are regarded as indicating positive results.…”

“…In summary, positive results were obtained with the agarose technique by Kiillen's group in both MS and other neurological disease, and there was no clear correlation with the stage of disease in MS. There is complete conflict of results with the capillary tube technique since positive results were found in MS but not other neurological disease by Myers & Ellison (1976), negative results in both groups by Strandgaard & Jorgenson (1972), positive results in other neurological disease by Nyerges et al (1974) and equivocal results in MS by .…”

Cellular hypersensitivity to brain antigen in children of a family with hereditary ataxia

“…It is difficult to deny the alternative explanation, however, that immunological reactivity may be secondary to pathological changes brought about by other mechanisms. For example, sensitisation to nervous tissue antigens can be detected after strokes (Rocklin et al, 1971;Alvord et al, 1974), and encephalitis (Behan et al, 1968;Nyerges et al, 1974). Such an issue is almost impossible to resolve in diseases like multiple sclerosis and Guillain-Barre syndrome because it cannot be predicted which individuals will develop the disease at some future time.…”

Lymphocyte transformation in the presence of myelin basic protein in multiple sclerosis and control subjects

“…Two groups obtained positive results in patients with other neurological disease as well as in MS (Rocklin 1972, Minderhoud et al 1978. There is complete conflict of results with the capillary tube technique since positive results were found in MS but not other neurological disease by Myers & Ellison (1976), negative results in both groups by Strandgaard & Jorgenson (1972), positive results in other neurological disease by Nyerges et al (1974) and equivocal results in MS by . Interpretation of this test is unusually complicated because both stimulation and inhibition are regarded as indicating positive results.…”

“…In summary, positive results were obtained with the agarose technique by Kiillen's group in both MS and other neurological disease, and there was no clear correlation with the stage of disease in MS. There is complete conflict of results with the capillary tube technique since positive results were found in MS but not other neurological disease by Myers & Ellison (1976), negative results in both groups by Strandgaard & Jorgenson (1972), positive results in other neurological disease by Nyerges et al (1974) and equivocal results in MS by .…”

Cellular hypersensitivity to brain antigen in children of a family with hereditary ataxia

“…It is difficult to deny the alternative explanation, however, that immunological reactivity may be secondary to pathological changes brought about by other mechanisms. For example, sensitisation to nervous tissue antigens can be detected after strokes (Rocklin et al, 1971;Alvord et al, 1974), and encephalitis (Behan et al, 1968;Nyerges et al, 1974). Such an issue is almost impossible to resolve in diseases like multiple sclerosis and Guillain-Barre syndrome because it cannot be predicted which individuals will develop the disease at some future time.…”

Lymphocyte transformation in the presence of myelin basic protein in multiple sclerosis and control subjects

“…Two groups obtained positive results in patients with other neurological disease as well as in MS (Rocklin 1972, Minderhoud et al 1978. There is complete conflict of results with the capillary tube technique since positive results were found in MS but not other neurological disease by Myers & Ellison (1976), negative results in both groups by Strandgaard & Jorgenson (1972), positive results in other neurological disease by Nyerges et al (1974) and equivocal results in MS by . Interpretation of this test is unusually complicated because both stimulation and inhibition are regarded as indicating positive results.…”

“…In summary, positive results were obtained with the agarose technique by Kiillen's group in both MS and other neurological disease, and there was no clear correlation with the stage of disease in MS. There is complete conflict of results with the capillary tube technique since positive results were found in MS but not other neurological disease by Myers & Ellison (1976), negative results in both groups by Strandgaard & Jorgenson (1972), positive results in other neurological disease by Nyerges et al (1974) and equivocal results in MS by .…”

Cellular hypersensitivity to brain antigen in children of a family with hereditary ataxia

“…It is difficult to deny the alternative explanation, however, that immunological reactivity may be secondary to pathological changes brought about by other mechanisms. For example, sensitisation to nervous tissue antigens can be detected after strokes (Rocklin et al, 1971;Alvord et al, 1974), and encephalitis (Behan et al, 1968;Nyerges et al, 1974). Such an issue is almost impossible to resolve in diseases like multiple sclerosis and Guillain-Barre syndrome because it cannot be predicted which individuals will develop the disease at some future time.…”